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  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

  • 2. Editorial Board

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    Editor-in-Chief
    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
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    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
    The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.

    The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.

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Liver, Pancreas and Biliary Tract

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Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection

Eun Young Cho*, Chang Soo Choi*, Ji-Hyun Cho, and Haak Cheoul Kim*

Departments of *Internal Medicine and Laboratory Medicine, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea

Correspondence to: Haak Cheoul Kim

Gut Liver 2011;5(1):70-76. https://doi.org/10.5009/gnl.2011.5.1.70

Published online November 30, -0001, Published date March 30, 2011

Copyright © Gut and Liver.

Abstract

Background/Aims: Few reports have described the association between mutations in the entire X gene of the hepatitis B virus (HBV) and the clinical status of HBV-infected patients. We studied the association between HBV X gene mutations and the disease status of patients infected with HBV genotype C. Methods: Mutations in the HBV X genes of 194 patients were determined by direct sequencing. The subject population consisted of patients with chronic hepatitis (n=60), liver cirrhosis (n=65), and hepatocellular carcinoma (HCC) (n=69). The sequencing results of these 3 groups were compared. Results: Each of the mutations G1386M, C1485T, C1653T, T1753V, A1762T, and G1764A was signifi cantly associated with the patient' clinical status. The T1753V (p<0.001) and A1762T/G1764A (p<0.001) mutations were found more frequently in Hepatitis B e antigen (HBeAg)-negative than in HBeAg-positive patients. Specifi c X gene mutations (G1386M, C1653T, and A1762T/ G1764A) were more prevalent in patients with liver cirrhosis and HCC than in chronic hepatitis patients (p<0.005 for all). In addition, the T1753V (p<0.001) and C1485T (p<0.001) mutations were signifi cantly more prevalent in HCC patients than in chronic hepatitis patients. Only the prevalence of the T1753V mutation increased as the HBV infection progressed from liver cirrhosis to HCC (p=0.023). Conclusions: Our fi ndings show a difference in the pattern of X gene mutations that were associated with the clinical status of patients with chronic HBV infection. (Gut Liver 2011;5:70-76)

Keywords: Hepatitis B virus, Hepatocellular carcinoma, Cirrhosis, Liver disease, X mutation


Article

Liver, Pancreas and Biliary Tract

Gut and Liver 2011; 5(1): 70-76

Published online March 30, 2011 https://doi.org/10.5009/gnl.2011.5.1.70

Copyright © Gut and Liver.

Association between Hepatitis B Virus X Gene Mutations and Clinical Status in Patients with Chronic Hepatitis B Infection

Eun Young Cho*, Chang Soo Choi*, Ji-Hyun Cho, and Haak Cheoul Kim*

Departments of *Internal Medicine and Laboratory Medicine, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan, Korea

Correspondence to:Haak Cheoul Kim

Abstract

Background/Aims: Few reports have described the association between mutations in the entire X gene of the hepatitis B virus (HBV) and the clinical status of HBV-infected patients. We studied the association between HBV X gene mutations and the disease status of patients infected with HBV genotype C. Methods: Mutations in the HBV X genes of 194 patients were determined by direct sequencing. The subject population consisted of patients with chronic hepatitis (n=60), liver cirrhosis (n=65), and hepatocellular carcinoma (HCC) (n=69). The sequencing results of these 3 groups were compared. Results: Each of the mutations G1386M, C1485T, C1653T, T1753V, A1762T, and G1764A was signifi cantly associated with the patient' clinical status. The T1753V (p<0.001) and A1762T/G1764A (p<0.001) mutations were found more frequently in Hepatitis B e antigen (HBeAg)-negative than in HBeAg-positive patients. Specifi c X gene mutations (G1386M, C1653T, and A1762T/ G1764A) were more prevalent in patients with liver cirrhosis and HCC than in chronic hepatitis patients (p<0.005 for all). In addition, the T1753V (p<0.001) and C1485T (p<0.001) mutations were signifi cantly more prevalent in HCC patients than in chronic hepatitis patients. Only the prevalence of the T1753V mutation increased as the HBV infection progressed from liver cirrhosis to HCC (p=0.023). Conclusions: Our fi ndings show a difference in the pattern of X gene mutations that were associated with the clinical status of patients with chronic HBV infection. (Gut Liver 2011;5:70-76)

Keywords: Hepatitis B virus, Hepatocellular carcinoma, Cirrhosis, Liver disease, X mutation

Gut and Liver

Vol.19 No.1
January, 2025

pISSN 1976-2283
eISSN 2005-1212

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