Article Search
검색
검색 팝업 닫기

Metrics

Help

  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

  • 2. Editorial Board

    Editor-in-Chief + MORE

    Editor-in-Chief
    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
  • 3. Editorial Office
  • 4. Articles
  • 5. Instructions for Authors
  • 6. File Download (PDF version)
  • 7. Ethical Standards
  • 8. Peer Review

    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
    The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.

    The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.

Search

Search

Year

to

Article Type

Original Article

Split Viewer

Prospective Multicenter Study of the Challenges Inherent in Using Large Cell-Type Stents for Bilateral Stent-in-Stent Placement in Patients with Inoperable Malignant Hilar Biliary Obstruction

Min Jae Yang1, Jin Hong Kim1, Jae Chul Hwang1, Byung Moo Yoo1, Sang Hyub Lee2, Ji Kon Ryu2, Yong-Tae Kim2, Sang Myung Woo3, Woo Jin Lee3, Seok Jeong4, Don Haeng Lee4

1Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea, 2Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea, 3Center for Liver Cancer, National Cancer Center, Goyang, Korea, 4Digestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea

Correspondence to: Correspondence to: Jin Hong Kim
Department of Gastroenterology, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon 16499, Korea
Tel: +82-31-219-6937, Fax: +82-31-219-5999, E-mail: jinhkim@ajou.ac.kr

Received: October 23, 2017; Revised: January 11, 2018; Accepted: March 9, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gut Liver 2018;12(6):722-727. https://doi.org/10.5009/gnl17468

Published online August 9, 2018, Published date November 15, 2018

Copyright © Gut and Liver.

Background/Aims

Although endoscopic bilateral stent-in-stent placement is challenging, many recent studies have reported promising outcomes regarding technical success and endoscopic re-intervention. This study aimed to evaluate the technical accessibility of stent-in-stent placement using large cell-type stents in patients with inoperable malignant hilar biliary obstruction.

Methods

Forty-three patients with inoperable malignant hilar biliary obstruction from four academic centers were prospectively enrolled from March 2013 to June 2015.

Results

Bilateral stent-in-stent placement using two large cell-type stents was successfully performed in 88.4% of the patients (38/43). In four of the five cases with technical failure, the delivery sheath of the second stent became caught in the hook-cross-type vertex of the large cell of the first stent, and subsequent attempts to pass a guidewire and stent assembly through the mesh failed. Functional success was achieved in all cases of technical success. Stent occlusion occurred in 63.2% of the patients (24/38), with a median patient survival of 300 days. The median stent patency was 198 days. The stent patency rate was 82.9%, 63.1%, and 32.1% at 3, 6, and 12 months postoperatively, respectively. Endoscopic re-intervention was performed in 14 patients, whereas 10 underwent percutaneous drainage.

Conclusions

Large cell-type stents for endoscopic bilateral stent-in-stent placement had acceptable functional success and stent patency when technically successful. However, the technical difficulty associated with the entanglement of the second stent delivery sheath in the hook-cross-type vertex of the first stent may preclude large cell-type stents from being considered as a dedicated standard tool for stent-in-stent placement.

Keywords: Cholangiopancreatography, endoscopic retrograde, Klatskin tumor, Cholestasis, intrahepatic, Self expandable metallic stents

Endoscopic biliary drainage using self-expandable metal stents (SEMSs) is the principal palliative procedure for treating inoperable malignant hilar biliary obstruction.13 With the recent advancements in SEMS technology, bilateral biliary drainage has become increasingly popular.416 This procedure aims to maintain an effective drainage of >50% of the liver volume and ultimately offer long-term palliation.1719 Better rates of survival20 and stent patency2123 and fewer re-interventions23 have been reported with bilateral stenting than with unilateral stenting.

Stent-in-stent (SIS) placement is a well-established endoscopic technique for bilateral biliary drainage. The major limitation of the SIS technique, however, is its technical difficulty, especially when passing the guidewire through the wire mesh of the indwelling first stent and delivering the second stent system to the desired contralateral intrahepatic duct.3,24 Furthermore, subsequent endoscopic re-interventions are as technically challenging as the initial procedure.15 Despite these widely known limitations, most feasibility studies on the efficacy of the SIS technique using dedicated SEMSs, such as an open-weave, cross-wired metal stent and a uniform large cell-type stent, have reported near-perfect technical success.5,810,15 Therefore, in this multicenter study, we aimed to evaluate the technical feasibility of SIS placement using large cell-type stents in patients with inoperable malignant hilar biliary obstruction.

1. Patients

From March 2013 to June 2015, patients with malignant hilar biliary obstruction who met the inclusion criteria were prospectively enrolled at four academic centers in Korea. The inclusion criteria were as follows: (1) >20 years of age; (2) Bismuth type II or higher malignant hilar biliary obstruction caused by cholangiocarcinoma or gallbladder cancer; and (3) unable to undergo curative resection because of locally advanced cancer, metastasis, or high surgical risk. The exclusion criteria included a history of prior stent placement or biliary surgery other than cholecystectomy or liver atrophy and uncontrolled coagulopathy (international normalized ratio >1.5 or platelet count <50,000/mm3). Written informed consent was obtained from all patients. The study was approved by each institution’s ethics review board (AJIRB-DEV-DE3-12-351, 1312-013-540, NCCCTS-MD-011, MD20130003) and was registered at cris.nih.go.kr (KCT0002198).

2. Endoscopic procedure

The Niti-STM large cell-type biliary stent (Taewoong Corp., Seoul, Korea) is a nitinol-based metal stent that contains large uniform mesh cells (6 mm square) for easy passage of the second stent (Fig. 1A). It consists of eight nitinol wires for optimal radial force (4.9 N), which are thicker (0.203 mm) than conventional biliary stents, and a hook and cross-mesh structure for low axial force (0.0 N). The stent has three radiopaque markings at each end and two in the midsection. An 8-F stent delivery system is used.

Computed tomography (CT) and/or magnetic resonance cholangiopancreatography-targeted selective drainage was performed before endoscopic retrograde cholangiopancreatography (ERCP). Following the placement of two guidewires (0.035-inch JagwireTM [Boston Scientific, Marlborough, MA, USA], 0.035-inch Tracer Metro® [Cook Medical, Bloomington, IN, USA], or 0.025-inch VisiGlide [Olympus Corp., Tokyo, Japan]) into the targeted bilateral intrahepatic branches across the hilar stricture, carbon dioxide cholangiography was performed first by injecting 10 to 20 mL of carbon dioxide to prevent post-procedure cholangitis in the contaminated and undrained ducts. If needed, contrast was injected to enhance the bile duct. The first stent was then inserted into either the left or right hepatic duct, depending on which duct was more difficult to access. Balloon dilation of the first stent was performed if the first stent was inadequately expanded or kinked. Thereafter, the guidewire was withdrawn to the hilar level and reinserted into the contralateral side via the mesh of the first stent, referencing the other landmark guidewire. If the guidewire could not be advanced into the contralateral intrahepatic duct through the first stent mesh, a J-shaped hydrophilic guidewire (Radifocus®; Terumo, Tokyo, Japan) and a catheter with an adjustable tip angle (TRUEtomeTM; Boston Scientific or Swing Tip®; Olympus Corp.) was used. The delivery system of the second stent was then advanced over the guidewire; however, if the delivery system was unable to be passed, dilation of the first stent was performed, and another attempt was made to pass the guidewire through the mesh cell. Subsequently, the contralateral stricture and first stent mesh were dilated using either a 6- to 8-mm balloon catheter (HurricaneTM biliary balloon catheter; Boston Scientific), a 6- or 7-F bougie (Soehendra® Biliary Dilation Catheter; Cook Medical), or a Soehendra® Stent Retriever (Cook Medical) over the guidewire. Finally, the second stent was placed in a Y-shaped position, considering the distal level of the stricture (Fig. 1B).

3. Measured outcomes and follow-up

Technical success was defined as the passage of bilateral large cell-type stents across the stricture using the SIS technique, in a single attempt. Functional success was defined as a reduction in the bilirubin level back to normal or to 75% of the pre-treatment level within the first month after the procedure. ERCP-related adverse events and grade of severity were defined according to the 1991 consensus criteria25 and the Tokyo guideline.26,27 Early and late adverse events were defined as any stent-related adverse event, including stent occlusion, within or after 30 days of stent placement, respectively. Stent occlusion was suspected if recurrent jaundice and/or clinical signs of acute cholangitis were observed and were confirmed by intrahepatic bile duct dilation identified on ultrasonography, CT, percutaneous cholangiography, or ERCP. Tumor overgrowth was defined when the obstruction level was identified at the proximal or distal end of a stent on CT and/or ERCP and contrast enhancement was seen at the obstruction level on CT. Biliary sludge was defined when contrast enhancement was not noted at the obstruction level on CT and fluoroscopic images showed intraluminal clearance of the stent after a biliary balloon sweep. Tumor ingrowth was defined when the obstruction level was detected inside of the stent lumen and enhancing tissue was seen within the stent on CT or when fluoroscopic images did not show intraluminal clearance of the stent with a biliary balloon sweep. Outpatient follow-up was conducted via liver function tests at 1-week post-procedure and then monthly for a period of 1-year post-procedure. Follow-up data collection was terminated at the date of death or at the 1-year follow-up visit of the last enrolled patient (May 2016). Patients were lost to follow-up when no contact was made with the patient within 3 months after the stent insertion.

4. Statistical analyses

For sample size calculation, we set the expected technical success rate of SIS placement using large cell-type stents to 96%9 with an 80% threshold rate with type I error of 0.05 and a statistical power of 0.8. The estimated sample size was 40 patients, assuming a 10% dropout rate. Mean and standard deviation were used to describe continuous variables, while percentages were used for categorical variables. The Kaplan-Meier method was used to assess the median time to recurrent biliary obstruction and overall patient survival. Statistical analyses were performed in an intention-to-treat manner, using SPSS version 18.0 (SPSS Inc., Chicago, IL, USA).

A total of 43 patients with inoperable malignant hilar biliary obstruction who met the inclusion criteria were enrolled in the study (Table 1). The causes of hilar biliary obstruction included cholangiocarcinoma in 27 patients and gallbladder carcinoma in 16 patients. The types of hilar obstruction, as based on the Bismuth-Corlette classification, were II in 14 patients, IIIa in 17 patients, IIIb in one patient, and IV in 11 patients. Fifteen patients (34.9%) underwent palliative chemotherapy or radio-therapy for carcinoma.

Stent-related outcomes are summarized in Table 2. Bilateral SIS placement using two large cell-type stents was successfully performed in 88.4% of patients (38/43). There were five cases of technical failure in which the Bismuth types were IIIa (n=2), IIIb (n=1), or IV (n=2). In the first case of failure, after placement of the first stent, the first guidewire could not be reinserted into the contralateral hepatic duct via the mesh of the first stent, despite the use of a hydrophilic guidewire and a catheter with an adjustable tip angle. In the remaining four cases of technical failure, the delivery sheath of the second stent could not be advanced through the first stent’s mesh, despite the guidewire being successfully placed in the contralateral intrahepatic duct via the mesh of the first stent. In one of four cases, bilateral stenting was finally achieved using a different type of stent for the second stent with a 6-F delivery sheath. In the other three cases, the delivery sheath of the second stent was caught in the hook-cross-type vertex of the first stent’s mesh cell; hence, even the 6-F bougie dilator and 7-F Soehendra® Stent Retriever could not be advanced outside the first stent’s mesh.

Functional success was achieved in all 38 patients for whom technical success was achieved. Stent occlusion occurred in 63.2% of patients (24/38), with a median patient survival of 300 days (interquartile range, 144 to 455 days), and cases of occlusion were caused by tumor ingrowth (n=17), ingrowth combined with overgrowth (n=4), or biliary sludge (n=3). Estimated median stent patency based on Kaplan-Meier analysis was 198 days (interquartile range, 68 to 328 days) (Fig. 2). The stent patency rate was 82.9% at 3 months, 63.1% at 6 months, and 32.1% at 1 year. Endoscopic re-intervention was performed in 14 patients (58.3%) with stent occlusion. Bilateral plastic stenting was performed in eight patients, unilateral plastic stenting in two patients, bilateral SEMS in three patients, and balloon sweeping in one patient. The remaining 10 patients with stent occlusion underwent percutaneous transhepatic biliary drainage. Ultimately, endoscopic re-intervention failed in three patients because of entanglement of the stent assembly in the mesh cells of the indwelling stents despite successful guidewire placement. In seven patients, percutaneous intervention was primarily performed owing to (1) newly developed additional intrahepatic duct dilation where SEMSs were not inserted, (2) a short life expectancy, or (3) a poor general condition of patients associated with sepsis following stent occlusion. Early adverse events occurred in three patients (7.0%) (Table 3). Post-ERCP pancreatitis and cholangitis developed in one patient each. These patients were managed conservatively. Post-ERCP cholecystitis developed in one patient, and endoscopic ultrasound-guided gallbladder drainage was performed. There was no procedure-related mortality.

There are multiple barriers to successfully performing bilateral SIS placement for inoperable malignant hilar biliary obstruction, related to initial bilateral biliary cannulation and second guidewire cannulation of the desired contralateral intrahepatic duct via the indwelling first stent wire mesh and subsequent advancement of the second stent delivery system through the wire mesh and hilar biliary stricture.3,24 At the time of endoscopic re-intervention, the guidewire should be advanced inside the indwelling stents and passed through the appropriate mesh cell of the indwelling stents, where it is expected that the subsequent stent assembly would not become entangled and could be advanced to the intrahepatic duct level. Therefore, the procedural steps for endoscopic re-intervention may be more challenging and complex than those of the initial SIS procedure.

To overcome these technical difficulties, an open-weave, cross-wired metal stent (Bonastent M-Hilar; Standard Sci Tech Inc., Seoul, Korea)5,10,15 and uniform large cell-type stent (Taewoong Corp.)711 have been used and have shown excellent technical and clinical outcomes. In the studies regarding the efficacy of large cell-type stents for SIS placement, the reported technical success rate in a single session was 96% to 100%, and the overall technical success was 100%.810 This high technical success rate has been explained by the unique mechanical properties of the large cell-type stent by previous studies.810 The 6-mm large cell can allow for easy insertion of the second stent through the first stent mesh and can facilitate further re-intervention following stent occlusion. The uniform cell structure of the large cell-type stent allows for flexibility in the placement of the second stent to adequately cover the distal portion of biliary stricture since the central portion of the stent should not necessarily be positioned in the hilar area.8,11 Other mechanical advantages of large cell-type stents are their low axial force and enhanced radial force.7,11

However, we encountered several cases of technical failure in our study, unlike that in previous studies.810 In this study, we found that second stent failure can occur owing to the delivery sheath tip being caught in the hook-cross-type vertex of the mesh cell of the first stent. If the guidewire contacts this hook-cross vertex of the mesh cell, the delivery sheath of the second stent over the guidewire could become entangled at that point because the vertex is relatively fixed and does not have an open weave. If this happens, the thicker nitinol wire interferes with the advancement of the stent assembly. In patients with a tight hilar stricture, another mesh cell negotiation to traverse a guide-wire and stent assembly could be very challenging. In the current study, changing the mesh through which a guidewire was passed failed in all patients with second stent delivery entanglement in the first stent mesh vertex.

The median stent patency in this study (198 days) was comparable to that in previous studies regarding large cell-type stents (105, 157, 202 days)810 and open-weave, cross-wired stents (150 and 238 days)5,15; however, the stent occlusion rate in the current study (63.2%) was somewhat higher than that in previous studies that considered large cell-type stents (42%, 45.5%, 60%)810 and much higher than that in studies that examined open-weave, cross-wired stents (6%, 30.8%, 42.9%).5,10,15 This result leads to a concern that the large cell-type stent may be vulnerable to stent occlusion by tumor ingrowth because of its wider mesh structure.7 However, a longer median patient survival (300 days) was noted in this study than in previously published studies regarding large cell-type stents (220 days)9,10 and open-weave, cross-wired stents (180 and 256 days).5,10,15 Therefore, further large-scale studies are warranted to address this issue. In this study, the need for percutaneous transhepatic biliary drainage (41.6%) was on the higher end of the range of the results published in previous studies regarding large cell-type stents (0%, 33.3%, 50%)810 or open-weave, cross-wired stents (4.2%, 33.3%, 50%).5,10,15 However, most patients who required percutaneous transhepatic biliary drainage were not candidates for endoscopic re-intervention because of their poor medical condition and unstable vital signs or newly developed additional intrahepatic duct dilation where bilateral SEMSs were not inserted.

The strengths of the current study include its suggestion of the structural limitations of large cell-type stents as well as the relatively larger study population than that in previous studies on large cell-type stents. Nevertheless, the study also had several limitations: first, previous feasibility studies have already shown the technical and clinical results of the large cell-type stent. However, the negative impact of large cell-type stents for SIS placement described in the present study presents a good starting point for further studies to investigate whether large cell-type stents could be considered as a dedicated standard tool for SIS placement for palliation of inoperable malignant hilar strictures. Second, our study had a single-arm design without a comparison group; therefore, validation of our results is necessary through future prospective randomized trials that compare large cell-type stents with a new stent or a conventional open cell-type stent. Third, the four participating academic centers in the current study did not share a uniform clinical strategy for palliative anti-cancer treatment. This could have led to a bias in the stent patency and re-intervention results.

In conclusion, large cell-type stents for endoscopic bilateral SIS placement had acceptable rates of functional success and stent patency, if technically successful. However, the technical difficulty associated with entanglement of the second stent delivery sheath in the hook-cross-type vertex of the first stent may preclude large cell-type stents from being considered as a dedicated standard tool for SIS placement. A modification of the current design of large cell-type stents to address this issue may contribute to better technical success and a wider application of large cell-type stents.

No potential conflict of interest relevant to this article was reported.

Fig. 1.(A) The Niti-STM large cell-type biliary stent (Taewoong Corp.). The hook-cross-type vertex of the mesh cell. (B) Carbon dioxide cholangiography (arrows) and bilateral stent-in-stent placement using large cell-type stents.
Fig. 2.Kaplan-Meier curve of cumulative stent patency.

Baseline Characteristics of Patients (n=43)

Characteristic Value
Age, yr 72.9±9.1
Sex, male/female 22/21
Cholangiocarcinoma/GB cancer 27 (62.8)/16 (37.2)
Bismuth type
 II 14 (32.6)
 IIIa 17 (39.5)
 IIIb 1 (2.3)
 IV 11 (25.6)
Karnofsky Performance Score 76.6±9.1
Adjuvant treatment
 Chemotherapy 12 (27.9)
 Radiotherapy 2 (4.7)
 Both 1 (2.3)
Total bilirubin level, mg/dL 8.9±6.4
Follow-up period, day 184 (38–732)

Data are presented as mean±SD, number (%), or median (range). GB, gallbladder.


Overall Outcomes of Endoscopic Bilateral Stent-in-Stent Placement Using Large Cell-Type Stents for Inoperable Malignant Hilar Biliary Obstruction

Outcomes Data
Technical success 38/43 (88.4)
Technical failure 5/43 (11.6)
 Bismuth type II/IIIa/IIIb/IV 0/2/1/2
 Failure in guidewire reinsertion via first stent mesh 1
 Second stent delivery passage failure via first stent mesh 4
Functional success 38/43 (88.4)
Stent occlusion 24/38 (63.2)
 Tumor ingrowth 17
 Tumor ingrowth and overgrowth 4
 Biliary sludge 3
Overall stent patency 198 (68–328)
 Patency rate at 3/6/12 mo, % 82.9/63.1/32.1
Overall patient survival, day 300 (144–455)
Endoscopic/percutaneous re-intervention, n (%) 14 (58.3)/10 (41.7)

Data are presented as number/number (%) or median (interquartile range).


Adverse Events Following Bilateral Stent-in-Stent Placement Using Large Cell Type Biliary Stents

Outcomes Data
Early adverse events, n (%) 3/43 (7.0)
 Pancreatitis 1 (Mild)
 Cholangitis 1 (Moderate)
 Cholecystitis 1 (Moderate)
Late adverse events, n (%) 24/38 (63.2)*
 Stent occlusion 24
 Multiple liver abscess 1

One patient had both stent occlusion and liver abscess.


  1. Soehendra, N, and Reynders-Frederix, V (1980). Palliative bile duct drainage: a new endoscopic method of introducing a transpapillary drain. Endoscopy. 12, 8-11.
    Pubmed CrossRef
  2. Singhal, D, van Gulik, TM, and Gouma, DJ (2005). Palliative management of hilar cholangiocarcinoma. Surg Oncol. 14, 59-74.
    Pubmed CrossRef
  3. Kim, JH (2011). Endoscopic stent placement in the palliation of malignant biliary obstruction. Clin Endosc. 44, 76-86.
    Pubmed KoreaMed CrossRef
  4. Lee, JH, Kang, DH, and Kim, JY (2007). Endoscopic bilateral metal stent placement for advanced hilar cholangiocarcinoma: a pilot study of a newly designed Y stent. Gastrointest Endosc. 66, 364-369.
    Pubmed CrossRef
  5. Park, DH, Lee, SS, and Moon, JH (2009). Newly designed stent for endoscopic bilateral stent-in-stent placement of metallic stents in patients with malignant hilar biliary strictures: multicenter prospective feasibility study (with videos). Gastrointest Endosc. 69, 1357-1360.
    Pubmed CrossRef
  6. Hwang, JC, Kim, JH, Lim, SG, Kim, SS, Yoo, BM, and Cho, SW (2011). Y-shaped endoscopic bilateral metal stent placement for malignant hilar biliary obstruction: prospective long-term study. Scand J Gastroenterol. 46, 326-332.
    Pubmed CrossRef
  7. Kogure, H, Isayama, H, and Kawakubo, K (2011). Endoscopic bilateral metallic stenting for malignant hilar obstruction using newly designed stents. J Hepatobiliary Pancreat Sci. 18, 653-657.
    Pubmed CrossRef
  8. Kogure, H, Isayama, H, and Nakai, Y (2011). Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study. Surg Endosc. 25, 463-467.
    Pubmed CrossRef
  9. Kogure, H, Isayama, H, and Nakai, Y (2014). High single-session success rate of endoscopic bilateral stent-in-stent placement with modified large cell Niti-S stents for malignant hilar biliary obstruction. Dig Endosc. 26, 93-99.
    Pubmed CrossRef
  10. Lee, JM, Lee, SH, and Chung, KH (2015). Small cell-versus large cell-sized metal stent in endoscopic bilateral stent-in-stent placement for malignant hilar biliary obstruction. Dig Endosc. 27, 692-699.
    Pubmed CrossRef
  11. Mukai, T, Yasuda, I, and Isayama, H (2011). Comparison of axial force and cell width of self-expandable metallic stents: which type of stent is better suited for hilar biliary strictures?. J Hepatobiliary Pancreat Sci. 18, 646-652.
    Pubmed CrossRef
  12. Naitoh, I, Hayashi, K, and Nakazawa, T (2012). Side-by-side versus stent-in-stent deployment in bilateral endoscopic metal stenting for malignant hilar biliary obstruction. Dig Dis Sci. 57, 3279-3285.
    Pubmed CrossRef
  13. Kim, KM, Lee, KH, and Chung, YH (2012). A comparison of bilateral stenting methods for malignant hilar biliary obstruction. Hepato-gastroenterology. 59, 341-346.
    Pubmed CrossRef
  14. Law, R, and Baron, TH (2013). Bilateral metal stents for hilar biliary obstruction using a 6Fr delivery system: outcomes following bilateral and side-by-side stent deployment. Dig Dis Sci. 58, 2667-2672.
    Pubmed CrossRef
  15. Lee, TH, Moon, JH, and Kim, JH (2013). Primary and revision efficacy of cross-wired metallic stents for endoscopic bilateral stent-in-stent placement in malignant hilar biliary strictures. Endoscopy. 45, 106-113.
    Pubmed CrossRef
  16. Kawakubo, K, Kawakami, H, and Kuwatani, M (2015). Single-step simultaneous side-by-side placement of a self-expandable metallic stent with a 6-Fr delivery system for unresectable malignant hilar biliary obstruction: a feasibility study. J Hepatobiliary Pancreat Sci. 22, 151-155.
    Pubmed CrossRef
  17. Dowsett, JF, Vaira, D, and Hatfield, AR (1989). Endoscopic biliary therapy using the combined percutaneous and endoscopic technique. Gastroenterology. 96, 1180-1186.
    Pubmed CrossRef
  18. Larghi, A, Tringali, A, Lecca, PG, Giordano, M, and Costamagna, G (2008). Management of hilar biliary strictures. Am J Gastroenterol. 103, 458-473.
    Pubmed CrossRef
  19. Vienne, A, Hobeika, E, and Gouya, H (2010). Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment. Gastrointest Endosc. 72, 728-735.
    Pubmed CrossRef
  20. Chang, WH, Kortan, P, and Haber, GB (1998). Outcome in patients with bifurcation tumors who undergo unilateral versus bilateral hepatic duct drainage. Gastrointest Endosc. 47, 354-362.
    Pubmed CrossRef
  21. Liberato, MJ, and Canena, JM (2012). Endoscopic stenting for hilar cholangiocarcinoma: efficacy of unilateral and bilateral placement of plastic and metal stents in a retrospective review of 480 patients. BMC Gastroenterol. 12, 103.
    Pubmed KoreaMed CrossRef
  22. Naitoh, I, Ohara, H, and Nakazawa, T (2009). Unilateral versus bilateral endoscopic metal stenting for malignant hilar biliary obstruction. J Gastroenterol Hepatol. 24, 552-557.
    Pubmed CrossRef
  23. Lee, TH, Kim, TH, and Moon, JH (2017). Bilateral versus unilateral placement of metal stents for inoperable high-grade malignant hilar biliary strictures: a multicenter, prospective, randomized study (with video). Gastrointest Endosc. 86, 817-827.
    Pubmed CrossRef
  24. Moon, JH, Rerknimitr, R, Kogure, H, Nakai, Y, and Isayama, H (2015). Topic controversies in the endoscopic management of malignant hilar strictures using metal stent: side-by-side versus stent-in-stent techniques. J Hepatobiliary Pancreat Sci. 22, 650-656.
    Pubmed CrossRef
  25. Cotton, PB, Lehman, G, and Vennes, J (1991). Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 37, 383-393.
    Pubmed CrossRef
  26. Kiriyama, S, Takada, T, and Strasberg, SM (2013). TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). J Hepatobiliary Pancreat Sci. 20, 24-34.
    Pubmed CrossRef
  27. Yokoe, M, Takada, T, and Strasberg, SM (2013). TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci. 20, 35-46.
    Pubmed CrossRef

Article

Original Article

Gut and Liver 2018; 12(6): 722-727

Published online November 15, 2018 https://doi.org/10.5009/gnl17468

Copyright © Gut and Liver.

Prospective Multicenter Study of the Challenges Inherent in Using Large Cell-Type Stents for Bilateral Stent-in-Stent Placement in Patients with Inoperable Malignant Hilar Biliary Obstruction

Min Jae Yang1, Jin Hong Kim1, Jae Chul Hwang1, Byung Moo Yoo1, Sang Hyub Lee2, Ji Kon Ryu2, Yong-Tae Kim2, Sang Myung Woo3, Woo Jin Lee3, Seok Jeong4, Don Haeng Lee4

1Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea, 2Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea, 3Center for Liver Cancer, National Cancer Center, Goyang, Korea, 4Digestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea

Correspondence to:Correspondence to: Jin Hong Kim
Department of Gastroenterology, Ajou University School of Medicine, 164 World cup-ro, Yeongtong-gu, Suwon 16499, Korea
Tel: +82-31-219-6937, Fax: +82-31-219-5999, E-mail: jinhkim@ajou.ac.kr

Received: October 23, 2017; Revised: January 11, 2018; Accepted: March 9, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims

Although endoscopic bilateral stent-in-stent placement is challenging, many recent studies have reported promising outcomes regarding technical success and endoscopic re-intervention. This study aimed to evaluate the technical accessibility of stent-in-stent placement using large cell-type stents in patients with inoperable malignant hilar biliary obstruction.

Methods

Forty-three patients with inoperable malignant hilar biliary obstruction from four academic centers were prospectively enrolled from March 2013 to June 2015.

Results

Bilateral stent-in-stent placement using two large cell-type stents was successfully performed in 88.4% of the patients (38/43). In four of the five cases with technical failure, the delivery sheath of the second stent became caught in the hook-cross-type vertex of the large cell of the first stent, and subsequent attempts to pass a guidewire and stent assembly through the mesh failed. Functional success was achieved in all cases of technical success. Stent occlusion occurred in 63.2% of the patients (24/38), with a median patient survival of 300 days. The median stent patency was 198 days. The stent patency rate was 82.9%, 63.1%, and 32.1% at 3, 6, and 12 months postoperatively, respectively. Endoscopic re-intervention was performed in 14 patients, whereas 10 underwent percutaneous drainage.

Conclusions

Large cell-type stents for endoscopic bilateral stent-in-stent placement had acceptable functional success and stent patency when technically successful. However, the technical difficulty associated with the entanglement of the second stent delivery sheath in the hook-cross-type vertex of the first stent may preclude large cell-type stents from being considered as a dedicated standard tool for stent-in-stent placement.

Keywords: Cholangiopancreatography, endoscopic retrograde, Klatskin tumor, Cholestasis, intrahepatic, Self expandable metallic stents

INTRODUCTION

Endoscopic biliary drainage using self-expandable metal stents (SEMSs) is the principal palliative procedure for treating inoperable malignant hilar biliary obstruction.13 With the recent advancements in SEMS technology, bilateral biliary drainage has become increasingly popular.416 This procedure aims to maintain an effective drainage of >50% of the liver volume and ultimately offer long-term palliation.1719 Better rates of survival20 and stent patency2123 and fewer re-interventions23 have been reported with bilateral stenting than with unilateral stenting.

Stent-in-stent (SIS) placement is a well-established endoscopic technique for bilateral biliary drainage. The major limitation of the SIS technique, however, is its technical difficulty, especially when passing the guidewire through the wire mesh of the indwelling first stent and delivering the second stent system to the desired contralateral intrahepatic duct.3,24 Furthermore, subsequent endoscopic re-interventions are as technically challenging as the initial procedure.15 Despite these widely known limitations, most feasibility studies on the efficacy of the SIS technique using dedicated SEMSs, such as an open-weave, cross-wired metal stent and a uniform large cell-type stent, have reported near-perfect technical success.5,810,15 Therefore, in this multicenter study, we aimed to evaluate the technical feasibility of SIS placement using large cell-type stents in patients with inoperable malignant hilar biliary obstruction.

MATERIALS AND METHODS

1. Patients

From March 2013 to June 2015, patients with malignant hilar biliary obstruction who met the inclusion criteria were prospectively enrolled at four academic centers in Korea. The inclusion criteria were as follows: (1) >20 years of age; (2) Bismuth type II or higher malignant hilar biliary obstruction caused by cholangiocarcinoma or gallbladder cancer; and (3) unable to undergo curative resection because of locally advanced cancer, metastasis, or high surgical risk. The exclusion criteria included a history of prior stent placement or biliary surgery other than cholecystectomy or liver atrophy and uncontrolled coagulopathy (international normalized ratio >1.5 or platelet count <50,000/mm3). Written informed consent was obtained from all patients. The study was approved by each institution’s ethics review board (AJIRB-DEV-DE3-12-351, 1312-013-540, NCCCTS-MD-011, MD20130003) and was registered at cris.nih.go.kr (KCT0002198).

2. Endoscopic procedure

The Niti-STM large cell-type biliary stent (Taewoong Corp., Seoul, Korea) is a nitinol-based metal stent that contains large uniform mesh cells (6 mm square) for easy passage of the second stent (Fig. 1A). It consists of eight nitinol wires for optimal radial force (4.9 N), which are thicker (0.203 mm) than conventional biliary stents, and a hook and cross-mesh structure for low axial force (0.0 N). The stent has three radiopaque markings at each end and two in the midsection. An 8-F stent delivery system is used.

Computed tomography (CT) and/or magnetic resonance cholangiopancreatography-targeted selective drainage was performed before endoscopic retrograde cholangiopancreatography (ERCP). Following the placement of two guidewires (0.035-inch JagwireTM [Boston Scientific, Marlborough, MA, USA], 0.035-inch Tracer Metro® [Cook Medical, Bloomington, IN, USA], or 0.025-inch VisiGlide [Olympus Corp., Tokyo, Japan]) into the targeted bilateral intrahepatic branches across the hilar stricture, carbon dioxide cholangiography was performed first by injecting 10 to 20 mL of carbon dioxide to prevent post-procedure cholangitis in the contaminated and undrained ducts. If needed, contrast was injected to enhance the bile duct. The first stent was then inserted into either the left or right hepatic duct, depending on which duct was more difficult to access. Balloon dilation of the first stent was performed if the first stent was inadequately expanded or kinked. Thereafter, the guidewire was withdrawn to the hilar level and reinserted into the contralateral side via the mesh of the first stent, referencing the other landmark guidewire. If the guidewire could not be advanced into the contralateral intrahepatic duct through the first stent mesh, a J-shaped hydrophilic guidewire (Radifocus®; Terumo, Tokyo, Japan) and a catheter with an adjustable tip angle (TRUEtomeTM; Boston Scientific or Swing Tip®; Olympus Corp.) was used. The delivery system of the second stent was then advanced over the guidewire; however, if the delivery system was unable to be passed, dilation of the first stent was performed, and another attempt was made to pass the guidewire through the mesh cell. Subsequently, the contralateral stricture and first stent mesh were dilated using either a 6- to 8-mm balloon catheter (HurricaneTM biliary balloon catheter; Boston Scientific), a 6- or 7-F bougie (Soehendra® Biliary Dilation Catheter; Cook Medical), or a Soehendra® Stent Retriever (Cook Medical) over the guidewire. Finally, the second stent was placed in a Y-shaped position, considering the distal level of the stricture (Fig. 1B).

3. Measured outcomes and follow-up

Technical success was defined as the passage of bilateral large cell-type stents across the stricture using the SIS technique, in a single attempt. Functional success was defined as a reduction in the bilirubin level back to normal or to 75% of the pre-treatment level within the first month after the procedure. ERCP-related adverse events and grade of severity were defined according to the 1991 consensus criteria25 and the Tokyo guideline.26,27 Early and late adverse events were defined as any stent-related adverse event, including stent occlusion, within or after 30 days of stent placement, respectively. Stent occlusion was suspected if recurrent jaundice and/or clinical signs of acute cholangitis were observed and were confirmed by intrahepatic bile duct dilation identified on ultrasonography, CT, percutaneous cholangiography, or ERCP. Tumor overgrowth was defined when the obstruction level was identified at the proximal or distal end of a stent on CT and/or ERCP and contrast enhancement was seen at the obstruction level on CT. Biliary sludge was defined when contrast enhancement was not noted at the obstruction level on CT and fluoroscopic images showed intraluminal clearance of the stent after a biliary balloon sweep. Tumor ingrowth was defined when the obstruction level was detected inside of the stent lumen and enhancing tissue was seen within the stent on CT or when fluoroscopic images did not show intraluminal clearance of the stent with a biliary balloon sweep. Outpatient follow-up was conducted via liver function tests at 1-week post-procedure and then monthly for a period of 1-year post-procedure. Follow-up data collection was terminated at the date of death or at the 1-year follow-up visit of the last enrolled patient (May 2016). Patients were lost to follow-up when no contact was made with the patient within 3 months after the stent insertion.

4. Statistical analyses

For sample size calculation, we set the expected technical success rate of SIS placement using large cell-type stents to 96%9 with an 80% threshold rate with type I error of 0.05 and a statistical power of 0.8. The estimated sample size was 40 patients, assuming a 10% dropout rate. Mean and standard deviation were used to describe continuous variables, while percentages were used for categorical variables. The Kaplan-Meier method was used to assess the median time to recurrent biliary obstruction and overall patient survival. Statistical analyses were performed in an intention-to-treat manner, using SPSS version 18.0 (SPSS Inc., Chicago, IL, USA).

RESULTS

A total of 43 patients with inoperable malignant hilar biliary obstruction who met the inclusion criteria were enrolled in the study (Table 1). The causes of hilar biliary obstruction included cholangiocarcinoma in 27 patients and gallbladder carcinoma in 16 patients. The types of hilar obstruction, as based on the Bismuth-Corlette classification, were II in 14 patients, IIIa in 17 patients, IIIb in one patient, and IV in 11 patients. Fifteen patients (34.9%) underwent palliative chemotherapy or radio-therapy for carcinoma.

Stent-related outcomes are summarized in Table 2. Bilateral SIS placement using two large cell-type stents was successfully performed in 88.4% of patients (38/43). There were five cases of technical failure in which the Bismuth types were IIIa (n=2), IIIb (n=1), or IV (n=2). In the first case of failure, after placement of the first stent, the first guidewire could not be reinserted into the contralateral hepatic duct via the mesh of the first stent, despite the use of a hydrophilic guidewire and a catheter with an adjustable tip angle. In the remaining four cases of technical failure, the delivery sheath of the second stent could not be advanced through the first stent’s mesh, despite the guidewire being successfully placed in the contralateral intrahepatic duct via the mesh of the first stent. In one of four cases, bilateral stenting was finally achieved using a different type of stent for the second stent with a 6-F delivery sheath. In the other three cases, the delivery sheath of the second stent was caught in the hook-cross-type vertex of the first stent’s mesh cell; hence, even the 6-F bougie dilator and 7-F Soehendra® Stent Retriever could not be advanced outside the first stent’s mesh.

Functional success was achieved in all 38 patients for whom technical success was achieved. Stent occlusion occurred in 63.2% of patients (24/38), with a median patient survival of 300 days (interquartile range, 144 to 455 days), and cases of occlusion were caused by tumor ingrowth (n=17), ingrowth combined with overgrowth (n=4), or biliary sludge (n=3). Estimated median stent patency based on Kaplan-Meier analysis was 198 days (interquartile range, 68 to 328 days) (Fig. 2). The stent patency rate was 82.9% at 3 months, 63.1% at 6 months, and 32.1% at 1 year. Endoscopic re-intervention was performed in 14 patients (58.3%) with stent occlusion. Bilateral plastic stenting was performed in eight patients, unilateral plastic stenting in two patients, bilateral SEMS in three patients, and balloon sweeping in one patient. The remaining 10 patients with stent occlusion underwent percutaneous transhepatic biliary drainage. Ultimately, endoscopic re-intervention failed in three patients because of entanglement of the stent assembly in the mesh cells of the indwelling stents despite successful guidewire placement. In seven patients, percutaneous intervention was primarily performed owing to (1) newly developed additional intrahepatic duct dilation where SEMSs were not inserted, (2) a short life expectancy, or (3) a poor general condition of patients associated with sepsis following stent occlusion. Early adverse events occurred in three patients (7.0%) (Table 3). Post-ERCP pancreatitis and cholangitis developed in one patient each. These patients were managed conservatively. Post-ERCP cholecystitis developed in one patient, and endoscopic ultrasound-guided gallbladder drainage was performed. There was no procedure-related mortality.

DISCUSSION

There are multiple barriers to successfully performing bilateral SIS placement for inoperable malignant hilar biliary obstruction, related to initial bilateral biliary cannulation and second guidewire cannulation of the desired contralateral intrahepatic duct via the indwelling first stent wire mesh and subsequent advancement of the second stent delivery system through the wire mesh and hilar biliary stricture.3,24 At the time of endoscopic re-intervention, the guidewire should be advanced inside the indwelling stents and passed through the appropriate mesh cell of the indwelling stents, where it is expected that the subsequent stent assembly would not become entangled and could be advanced to the intrahepatic duct level. Therefore, the procedural steps for endoscopic re-intervention may be more challenging and complex than those of the initial SIS procedure.

To overcome these technical difficulties, an open-weave, cross-wired metal stent (Bonastent M-Hilar; Standard Sci Tech Inc., Seoul, Korea)5,10,15 and uniform large cell-type stent (Taewoong Corp.)711 have been used and have shown excellent technical and clinical outcomes. In the studies regarding the efficacy of large cell-type stents for SIS placement, the reported technical success rate in a single session was 96% to 100%, and the overall technical success was 100%.810 This high technical success rate has been explained by the unique mechanical properties of the large cell-type stent by previous studies.810 The 6-mm large cell can allow for easy insertion of the second stent through the first stent mesh and can facilitate further re-intervention following stent occlusion. The uniform cell structure of the large cell-type stent allows for flexibility in the placement of the second stent to adequately cover the distal portion of biliary stricture since the central portion of the stent should not necessarily be positioned in the hilar area.8,11 Other mechanical advantages of large cell-type stents are their low axial force and enhanced radial force.7,11

However, we encountered several cases of technical failure in our study, unlike that in previous studies.810 In this study, we found that second stent failure can occur owing to the delivery sheath tip being caught in the hook-cross-type vertex of the mesh cell of the first stent. If the guidewire contacts this hook-cross vertex of the mesh cell, the delivery sheath of the second stent over the guidewire could become entangled at that point because the vertex is relatively fixed and does not have an open weave. If this happens, the thicker nitinol wire interferes with the advancement of the stent assembly. In patients with a tight hilar stricture, another mesh cell negotiation to traverse a guide-wire and stent assembly could be very challenging. In the current study, changing the mesh through which a guidewire was passed failed in all patients with second stent delivery entanglement in the first stent mesh vertex.

The median stent patency in this study (198 days) was comparable to that in previous studies regarding large cell-type stents (105, 157, 202 days)810 and open-weave, cross-wired stents (150 and 238 days)5,15; however, the stent occlusion rate in the current study (63.2%) was somewhat higher than that in previous studies that considered large cell-type stents (42%, 45.5%, 60%)810 and much higher than that in studies that examined open-weave, cross-wired stents (6%, 30.8%, 42.9%).5,10,15 This result leads to a concern that the large cell-type stent may be vulnerable to stent occlusion by tumor ingrowth because of its wider mesh structure.7 However, a longer median patient survival (300 days) was noted in this study than in previously published studies regarding large cell-type stents (220 days)9,10 and open-weave, cross-wired stents (180 and 256 days).5,10,15 Therefore, further large-scale studies are warranted to address this issue. In this study, the need for percutaneous transhepatic biliary drainage (41.6%) was on the higher end of the range of the results published in previous studies regarding large cell-type stents (0%, 33.3%, 50%)810 or open-weave, cross-wired stents (4.2%, 33.3%, 50%).5,10,15 However, most patients who required percutaneous transhepatic biliary drainage were not candidates for endoscopic re-intervention because of their poor medical condition and unstable vital signs or newly developed additional intrahepatic duct dilation where bilateral SEMSs were not inserted.

The strengths of the current study include its suggestion of the structural limitations of large cell-type stents as well as the relatively larger study population than that in previous studies on large cell-type stents. Nevertheless, the study also had several limitations: first, previous feasibility studies have already shown the technical and clinical results of the large cell-type stent. However, the negative impact of large cell-type stents for SIS placement described in the present study presents a good starting point for further studies to investigate whether large cell-type stents could be considered as a dedicated standard tool for SIS placement for palliation of inoperable malignant hilar strictures. Second, our study had a single-arm design without a comparison group; therefore, validation of our results is necessary through future prospective randomized trials that compare large cell-type stents with a new stent or a conventional open cell-type stent. Third, the four participating academic centers in the current study did not share a uniform clinical strategy for palliative anti-cancer treatment. This could have led to a bias in the stent patency and re-intervention results.

In conclusion, large cell-type stents for endoscopic bilateral SIS placement had acceptable rates of functional success and stent patency, if technically successful. However, the technical difficulty associated with entanglement of the second stent delivery sheath in the hook-cross-type vertex of the first stent may preclude large cell-type stents from being considered as a dedicated standard tool for SIS placement. A modification of the current design of large cell-type stents to address this issue may contribute to better technical success and a wider application of large cell-type stents.

CONFLICTS OF INTEREST

No potential conflict of interest relevant to this article was reported.

Fig 1.

Figure 1.(A) The Niti-STM large cell-type biliary stent (Taewoong Corp.). The hook-cross-type vertex of the mesh cell. (B) Carbon dioxide cholangiography (arrows) and bilateral stent-in-stent placement using large cell-type stents.
Gut and Liver 2018; 12: 722-727https://doi.org/10.5009/gnl17468

Fig 2.

Figure 2.Kaplan-Meier curve of cumulative stent patency.
Gut and Liver 2018; 12: 722-727https://doi.org/10.5009/gnl17468

Table 1 Baseline Characteristics of Patients (n=43)

CharacteristicValue
Age, yr72.9±9.1
Sex, male/female22/21
Cholangiocarcinoma/GB cancer27 (62.8)/16 (37.2)
Bismuth type
 II14 (32.6)
 IIIa17 (39.5)
 IIIb1 (2.3)
 IV11 (25.6)
Karnofsky Performance Score76.6±9.1
Adjuvant treatment
 Chemotherapy12 (27.9)
 Radiotherapy2 (4.7)
 Both1 (2.3)
Total bilirubin level, mg/dL8.9±6.4
Follow-up period, day184 (38–732)

Data are presented as mean±SD, number (%), or median (range). GB, gallbladder.


Table 2 Overall Outcomes of Endoscopic Bilateral Stent-in-Stent Placement Using Large Cell-Type Stents for Inoperable Malignant Hilar Biliary Obstruction

OutcomesData
Technical success38/43 (88.4)
Technical failure5/43 (11.6)
 Bismuth type II/IIIa/IIIb/IV0/2/1/2
 Failure in guidewire reinsertion via first stent mesh1
 Second stent delivery passage failure via first stent mesh4
Functional success38/43 (88.4)
Stent occlusion24/38 (63.2)
 Tumor ingrowth17
 Tumor ingrowth and overgrowth4
 Biliary sludge3
Overall stent patency198 (68–328)
 Patency rate at 3/6/12 mo, %82.9/63.1/32.1
Overall patient survival, day300 (144–455)
Endoscopic/percutaneous re-intervention, n (%)14 (58.3)/10 (41.7)

Data are presented as number/number (%) or median (interquartile range).


Table 3 Adverse Events Following Bilateral Stent-in-Stent Placement Using Large Cell Type Biliary Stents

OutcomesData
Early adverse events, n (%)3/43 (7.0)
 Pancreatitis1 (Mild)
 Cholangitis1 (Moderate)
 Cholecystitis1 (Moderate)
Late adverse events, n (%)24/38 (63.2)*
 Stent occlusion24
 Multiple liver abscess1

*One patient had both stent occlusion and liver abscess.


References

  1. Soehendra, N, and Reynders-Frederix, V (1980). Palliative bile duct drainage: a new endoscopic method of introducing a transpapillary drain. Endoscopy. 12, 8-11.
    Pubmed CrossRef
  2. Singhal, D, van Gulik, TM, and Gouma, DJ (2005). Palliative management of hilar cholangiocarcinoma. Surg Oncol. 14, 59-74.
    Pubmed CrossRef
  3. Kim, JH (2011). Endoscopic stent placement in the palliation of malignant biliary obstruction. Clin Endosc. 44, 76-86.
    Pubmed KoreaMed CrossRef
  4. Lee, JH, Kang, DH, and Kim, JY (2007). Endoscopic bilateral metal stent placement for advanced hilar cholangiocarcinoma: a pilot study of a newly designed Y stent. Gastrointest Endosc. 66, 364-369.
    Pubmed CrossRef
  5. Park, DH, Lee, SS, and Moon, JH (2009). Newly designed stent for endoscopic bilateral stent-in-stent placement of metallic stents in patients with malignant hilar biliary strictures: multicenter prospective feasibility study (with videos). Gastrointest Endosc. 69, 1357-1360.
    Pubmed CrossRef
  6. Hwang, JC, Kim, JH, Lim, SG, Kim, SS, Yoo, BM, and Cho, SW (2011). Y-shaped endoscopic bilateral metal stent placement for malignant hilar biliary obstruction: prospective long-term study. Scand J Gastroenterol. 46, 326-332.
    Pubmed CrossRef
  7. Kogure, H, Isayama, H, and Kawakubo, K (2011). Endoscopic bilateral metallic stenting for malignant hilar obstruction using newly designed stents. J Hepatobiliary Pancreat Sci. 18, 653-657.
    Pubmed CrossRef
  8. Kogure, H, Isayama, H, and Nakai, Y (2011). Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study. Surg Endosc. 25, 463-467.
    Pubmed CrossRef
  9. Kogure, H, Isayama, H, and Nakai, Y (2014). High single-session success rate of endoscopic bilateral stent-in-stent placement with modified large cell Niti-S stents for malignant hilar biliary obstruction. Dig Endosc. 26, 93-99.
    Pubmed CrossRef
  10. Lee, JM, Lee, SH, and Chung, KH (2015). Small cell-versus large cell-sized metal stent in endoscopic bilateral stent-in-stent placement for malignant hilar biliary obstruction. Dig Endosc. 27, 692-699.
    Pubmed CrossRef
  11. Mukai, T, Yasuda, I, and Isayama, H (2011). Comparison of axial force and cell width of self-expandable metallic stents: which type of stent is better suited for hilar biliary strictures?. J Hepatobiliary Pancreat Sci. 18, 646-652.
    Pubmed CrossRef
  12. Naitoh, I, Hayashi, K, and Nakazawa, T (2012). Side-by-side versus stent-in-stent deployment in bilateral endoscopic metal stenting for malignant hilar biliary obstruction. Dig Dis Sci. 57, 3279-3285.
    Pubmed CrossRef
  13. Kim, KM, Lee, KH, and Chung, YH (2012). A comparison of bilateral stenting methods for malignant hilar biliary obstruction. Hepato-gastroenterology. 59, 341-346.
    Pubmed CrossRef
  14. Law, R, and Baron, TH (2013). Bilateral metal stents for hilar biliary obstruction using a 6Fr delivery system: outcomes following bilateral and side-by-side stent deployment. Dig Dis Sci. 58, 2667-2672.
    Pubmed CrossRef
  15. Lee, TH, Moon, JH, and Kim, JH (2013). Primary and revision efficacy of cross-wired metallic stents for endoscopic bilateral stent-in-stent placement in malignant hilar biliary strictures. Endoscopy. 45, 106-113.
    Pubmed CrossRef
  16. Kawakubo, K, Kawakami, H, and Kuwatani, M (2015). Single-step simultaneous side-by-side placement of a self-expandable metallic stent with a 6-Fr delivery system for unresectable malignant hilar biliary obstruction: a feasibility study. J Hepatobiliary Pancreat Sci. 22, 151-155.
    Pubmed CrossRef
  17. Dowsett, JF, Vaira, D, and Hatfield, AR (1989). Endoscopic biliary therapy using the combined percutaneous and endoscopic technique. Gastroenterology. 96, 1180-1186.
    Pubmed CrossRef
  18. Larghi, A, Tringali, A, Lecca, PG, Giordano, M, and Costamagna, G (2008). Management of hilar biliary strictures. Am J Gastroenterol. 103, 458-473.
    Pubmed CrossRef
  19. Vienne, A, Hobeika, E, and Gouya, H (2010). Prediction of drainage effectiveness during endoscopic stenting of malignant hilar strictures: the role of liver volume assessment. Gastrointest Endosc. 72, 728-735.
    Pubmed CrossRef
  20. Chang, WH, Kortan, P, and Haber, GB (1998). Outcome in patients with bifurcation tumors who undergo unilateral versus bilateral hepatic duct drainage. Gastrointest Endosc. 47, 354-362.
    Pubmed CrossRef
  21. Liberato, MJ, and Canena, JM (2012). Endoscopic stenting for hilar cholangiocarcinoma: efficacy of unilateral and bilateral placement of plastic and metal stents in a retrospective review of 480 patients. BMC Gastroenterol. 12, 103.
    Pubmed KoreaMed CrossRef
  22. Naitoh, I, Ohara, H, and Nakazawa, T (2009). Unilateral versus bilateral endoscopic metal stenting for malignant hilar biliary obstruction. J Gastroenterol Hepatol. 24, 552-557.
    Pubmed CrossRef
  23. Lee, TH, Kim, TH, and Moon, JH (2017). Bilateral versus unilateral placement of metal stents for inoperable high-grade malignant hilar biliary strictures: a multicenter, prospective, randomized study (with video). Gastrointest Endosc. 86, 817-827.
    Pubmed CrossRef
  24. Moon, JH, Rerknimitr, R, Kogure, H, Nakai, Y, and Isayama, H (2015). Topic controversies in the endoscopic management of malignant hilar strictures using metal stent: side-by-side versus stent-in-stent techniques. J Hepatobiliary Pancreat Sci. 22, 650-656.
    Pubmed CrossRef
  25. Cotton, PB, Lehman, G, and Vennes, J (1991). Endoscopic sphincterotomy complications and their management: an attempt at consensus. Gastrointest Endosc. 37, 383-393.
    Pubmed CrossRef
  26. Kiriyama, S, Takada, T, and Strasberg, SM (2013). TG13 guidelines for diagnosis and severity grading of acute cholangitis (with videos). J Hepatobiliary Pancreat Sci. 20, 24-34.
    Pubmed CrossRef
  27. Yokoe, M, Takada, T, and Strasberg, SM (2013). TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci. 20, 35-46.
    Pubmed CrossRef
Gut and Liver

Vol.19 No.1
January, 2025

pISSN 1976-2283
eISSN 2005-1212

qrcode
qrcode

Share this article on :

  • line

Popular Keywords

Gut and LiverQR code Download
qr-code

Editorial Office