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Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE
Yong Chan Lee |
Professor of Medicine Director, Gastrointestinal Research Laboratory Veterans Affairs Medical Center, Univ. California San Francisco San Francisco, USA |
Jong Pil Im | Seoul National University College of Medicine, Seoul, Korea |
Robert S. Bresalier | University of Texas M. D. Anderson Cancer Center, Houston, USA |
Steven H. Itzkowitz | Mount Sinai Medical Center, NY, USA |
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Byung-Wook Kim1 , Jong Jae Park2 , Hee Seok Moon3 , Wan Sik Lee4 , Ki-Nam Shim5 , Gwang Ho Baik6 , Yun Jeong Lim7 , Hang Lak Lee8 , Young Hoon Youn9 , Jun Chul Park10 , In-Kyung Sung11 , Hyunsoo Chung12 , Jeong Seop Moon13 , Gwang Ha Kim14 , Su Jin Hong15 , Hyuk Soon Choi16
Correspondence to: Jong Jae Park
ORCID https://orcid.org/0000-0002-4642-5405
E-mail gi7pjj@korea.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Gut Liver 2024;18(2):257-264. https://doi.org/10.5009/gnl230242
Published online February 22, 2024, Published date March 15, 2024
Copyright © Gut and Liver.
Background/Aims: Tegoprazan is a novel potassium-competitive acid blocker that has beneficial effects on acid-related disorders such as gastroesophageal reflux and peptic ulcer diseases. This study aimed to validate the effect of tegoprazan on endoscopic submucosal dissection (ESD)-induced artificial ulcers.
Methods: Patients from 16 centers in Korea who underwent ESD for gastric neoplasia were enrolled. After ESD, pantoprazole was administered intravenously for 48 hours. The patients were randomly allocated to either the tegoprazan or esomeprazole group. Tegoprazan 50 mg or esomeprazole 40 mg were administered for 4 weeks, after which gastroscopic evaluation was performed. If the artificial ulcer had not healed, the same dose of tegoprazan or esomeprazole was administered for an additional 4 weeks, and a gastroscopic evaluation was performed.
Results: One hundred sixty patients were enrolled in this study. The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in the tegoprazan and esomeprazole groups, respectively (p=0.006). At 8 weeks after ESD, the cumulative ulcer healing rates were 73.7% (56/76) and 77.9% (53/68) in the tegoprazan and esomeprazole groups, respectively (p=0.210). Delayed bleeding occurred in two patients in the tegoprazan group (2.6%) and in one patient in the esomeprazole group (1.5%). Other adverse events were negligible in both groups.
Conclusions: Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.
Keywords: Tegoprazan, Endoscopic resection, Endoscopic submucosal dissection, Gastric neoplasia, Multicenter prospective randomized study
Acid-reducing agents, such as proton pump inhibitors (PPIs), are administered after endoscopic submucosal dissection (ESD) for gastric neoplasia and non-ampullary duodenal tumors to avoid adverse events such as delayed bleeding.1-3 PPIs should be administered before meal; however, approximately half the patients do not take PPIs before breakfast,4 thus limiting their effects. Potassium-competitive acid blockers (P-CABs), which are novel acid-reducing agents, have been introduced to overcome the limitations of PPIs. P-CABs can be taken regardless of the meal times.
Vonoprazan, one of the P-CABs developed in Japan, has shown some benefits over PPIs in Helicobacter pylori eradication and the treatment of peptic ulcer diseases and gastroesophageal reflux diseases.5-7 Vonoprazan was also as effective as PPIs in preventing bleeding after ESD and healing of artificial ulcers after ESD for gastric neoplasia.8,9 Tegoprazan is a novel P-CAB developed in Korea that suppresses gastric acid secretion faster and more potently than PPIs.10 It is as effective as PPIs in the treatment of gastric ulcers and in H. pylori eradication.11,12 Tegoprazan is also effective in the treatment of gastroesophageal reflux diseases.13,14 However, the effect of tegoprazan in healing artificial ulcers after ESD is yet to be elucidated. This study aimed to evaluate the efficacy and safety of tegoprazan in the treatment of artificial ulcers after ESD in comparison to those of PPIs.
This study was a multicenter, randomized, double-blind, active-controlled, non-inferiority trial comparing tegoprazan (50 mg/day) and esomeprazole (40 mg/day). The study protocol was approved by the Korean Ministry of Food and Drug Safety (Registration number 32524) and the institutional review boards of each institution including Korea University Guro Hospital (IRB number: 2020GR0069). This study followed the Declaration of Helsinki and the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use‐Good Clinical Practice guidelines. Informed consent was obtained from all patients prior to enrollment. This study was registered at the Korean Disease Control and Prevention Agency registration site, Clinical Research Information Service (KCT0005470).
Drug distribution was determined according to the drug randomization number generated by an interactive web response system (cubeIWRS; CRScube Inc., Seoul, Korea). A double‐dummy method, using matching tegoprazan 50 mg and esomeprazole 40 mg, was employed to ensure that the study was double-blinded with key codes kept off-site by an external data manager. All medications were provided in sealed boxes and supplied by the medication supervisor to ensure blinded allocation. Blinded data were securely stored and could only be accessed by authorized personnel. All authors had access to the study data and reviewed and approved the final manuscript.
This study was performed at 16 centers in Korea. Inclusion criteria were as follows: patients aged 20 to 75 years who were diagnosed histologically and endoscopically with (1) gastric adenoma; (2) differentiated type gastric adenocarcinoma without ulcer; (3) differentiated type gastric adenocarcinoma with ulcer not involving submucosa less than 3.0 cm; (4) differentiated type gastric adenocarcinoma infiltrating submucosa less than 500 μm without ulcer less than 3.0 cm; and (5) undifferentiated type gastric adenocarcinoma not involving the submucosa without ulcer less than 2.0 cm. Exclusion criteria were as follows: (1) the size of artificial ulcer after ESD was over 4.0 cm; (2) overt bleeding or perforation after ESD; (3) past history of upper gastrointestinal tract surgery; (4) esophageal stricture, gastric outlet obstruction, or active peptic ulcer; (5) follow-up gastroscopy not available; (6) past history of adverse events to tegoprazan, PPI, or benzimidazole; (7) patients who were taking atazanavir, nelfinavir, rilpivirine, terfenadine, cisapride, pimozide, or astemizole; (8) pregnant or nursing women; (9) patients with uncontrolled cardiopulmonary diseases, renal diseases, liver diseases, neurologic diseases, or endocrine diseases including diabetes; (10) patients with cognition disorder or mental retardation; (11) patients who were taking anti-depressants, anxiolytics, or anti-psychotics; (12) patients who took PPI or H2 receptor antagonists within 2 weeks before ESD; (13) patients who were taking steroids, nonsteroidal anti-inflammatory drugs, aspirin, anti-platelet agents, or anticoagulants during the study period; (14) patients with aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, or bilirubin over 2 times the reference value; or (15) patients with blood urea nitrogen or creatinine over 1.5 times the reference value. Fasting serum gastrin level was checked on day zero and 4 and 8 weeks after ESD.
ESD was performed under conscious sedation. Sedative drugs were chosen by each endoscopist’s preference. A mixture of 0.001% epinephrine, 0.1% indigo carmine, and normal saline was injected into submucosal layer and mucosal cutting followed by submucosal dissection was performed using each endoscopist’s preference of knives. Hemorrhage during the procedure was controlled with hemostatic forceps. After ESD, the size of artificial ulcer was measured using biopsy forceps.
Immediately after ESD, a bolus of 80 mg pantoprazole was administered intravenously, followed by 8 mg per hour for 48 hours. Eligible patients were randomly assigned in a 1:1 ratio to receive either tegoprazan or esomeprazole during this period. Two days after ESD, the patients were instructed to take one tablet of 50 mg tegoprazan with one placebo esomeprazole tablet (tegoprazan group) or one placebo tegoprazan tablet with one tablet of 40 mg esomeprazole (esomeprazole group) once daily before breakfast for 4 weeks. Gastroscopic evaluation was performed 4 weeks after ESD. When an artificial ulcer was found in the active or healing stage according to Sakita-Miwa’s classification on gastroscopy 4 weeks after ESD, 50 mg tegoprazan with placebo or 40 mg esomeprazole with placebo was administered 4 weeks more. In these patients, gastroscopic evaluation was performed again 8 weeks after ESD. The study process is illustrated in Fig. 1.
The primary endpoint of this study was the healing rates of ESD-induced artificial ulcers at 4 and 8 weeks. The secondary endpoints were as follows: (1) healing rates of ESD-induced artificial ulcers at 4 weeks and 8 weeks; (2) change in ulcer size; and (3) the incidence of delayed bleeding. Healing of ESD-induced artificial ulcer was defined as the complete closure of the mucosal defect. The ulcer size was measured as follows: the mucosal defect after ESD was considered elliptical, and the area was calculated by multiplying the long axis radius and the short axis radius, followed by multiplying π, and expressed in mm2. The shrinkage rates of the artificial ulcers at 4 and 8 weeks were also compared as an exploratory endpoint. The shrinkage rate of artificial ulcers was calculated as the ratio of ulcer size at 4 and 8 weeks to the ulcer size immediately after ESD. The size of the artificial ulcer was measured using opening biopsy forceps. Delayed bleeding was defined by overt hemorrhage signs such as hematemesis or melena over 24 hours after initiating either tegoprazan or esomeprazole along with a decrease in hemoglobin level of over 2.0 g/dL.
Safety was evaluated using vital signs (blood pressure, heart rate, and body temperature), physical examination, serum gastrin level, and incidence of treatment-emergent adverse events (TEAEs). A TEAE was defined as an adverse event that occurred after the participant received the study drug. TEAEs were categorized by severity and relativity and compared between the treatment groups. Adverse events were analyzed in the safety set.
For sample size calculation, the healing rate of artificial ulcers at 8 weeks was assumed to be 95.5% for tegoprazan and esomeprazole, with a non-inferiority margin of –10% and a power of 80% at a significant level of 2.5% (one-sided).15 While a direct comparison between vonoprazan and tegoprazan for artificial ulcer healing is lacking, an indirect comparison was conducted using data from reports. Specifically, it was found that vonoprazan exhibited comparable effectiveness to lansoprazole in healing gastric ulcers (93.5% for vonoprazan and 93.8% for lansoprazole), and similarly, tegoprazan demonstrated comparable efficacy to lansoprazole in gastric ulcer healing (95.0% for tegoprazan and 95.7% for lansoprazole).6,11 The total sample size was 160 subjects, with 80 patients per treatment group, considering a 15% drop-out.
For continuous variables, the values are provided as the number of subjects, mean, standard deviation, median, minimum and maximum. For categorical variables, the values are presented as frequencies and percentages. The non-inferiority test of tegoprazan versus esomeprazole in healing rate was to be declared if the lower bound of the two-sided 95% confidence interval for the difference between the two arms was greater than the non-inferiority margin, –10%. Continuous variables were compared by the Student t-test or Wilcoxon rank-sum test depending on whether the normality assumption was satisfied. Categorical variables were compared by the chi-square test or Fisher exact test depending on whether 20% or more of cells with an expected frequency of 5 or less were found.
All two-sided statistical tests were performed at a significance level of 5% unless otherwise specified. Statistical analyses were performed using SAS 9.4 (SAS Institution Inc., Cary, NC, USA).
Among the 167 patients with an artificial ulcer after ESD who were screened, three were ineligible based on the inclusion/exclusion criteria, and four withdrew their consent. These participants were considered to have screening failure, and the remaining 160 patients were randomized in a 1:1 ratio to one of the two treatment arms: tegoprazan or esomeprazole. Among the 160 randomized patients, 16 (10.0%) were discontinued from the study due to the lack of viable data (n=10, 6.3%), violation of an inclusion/exclusion criteria (n=5, 3.1%), or withdrawal of consent before exposure to the study drug (n=1, 0.6%) (Fig. 2). The baseline characteristics of the patients are summarized in Table 1. No significant differences in baseline characteristics were observed between the treatment groups.
Baseline Characteristic of Patients in the Full Analysis Set
Characteristic | Tegoprazan group (n=76) | Esomeprazole group (n=68) |
---|---|---|
Sex, No. (%) | ||
Male | 57 (75.0) | 46 (67.7) |
Female | 19 (25.0) | 22 (32.3) |
Age, mean±SD, yr | 62.0±7.4 | 63.0±7.8 |
Social history, No. (%) | ||
Smoking | 16 (21.1) | 9 (13.2) |
Alcohol | 29 (38.2) | 18 (26.5) |
Pre-procedural histology, No. (%) | ||
Adenoma, low grade dysplasia | 41 (54.0) | 37 (54.4) |
Adenoma, high grade dysplasia | 13 (17.1) | 13 (19.1) |
Differentiated adenocarcinoma | 17 (22.4) | 17 (25.0) |
Undifferentiated adenocarcinoma | 2 (2.6) | 1 (1.5) |
Mixed | 3 (4.0) | 0 |
Ulcer size immediately after ESD, mean±SD, mm2 | 507.1±277.7 | 562.9±324.8 |
ESD, endoscopic submucosal dissection.
The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in tegoprazan group and in esomeprazole group, respectively. The percentage difference between the tegoprazan group and esomeprazole group was <–10% (95% confidence interval, –6.07 to 22.48), which confirmed the non-inferiority of the tegoprazan group in comparison to the esomeprazole group. At 8 weeks after ESD, the cumulative healing rates of artificial ulcers were 73.7% (56/76) and 77.9% (53/68) in tegoprazan and esomeprazole groups, respectively (95% confidence interval, –18.23 to 9.71). The results are summarized in Table 2. Immediately after ESD, the ulcer size was 508.18±274.10 mm2 and 585.63±309.72 mm2 in tegoprazan group and esomeprazole groups, respectively (p=0.180). Four weeks after ESD, the ulcer size was 51.63±75.06 mm2 and 60.26±79.51 mm2 in tegoprazan and esomeprazole groups, respectively (p=0.400). Eight weeks after ESD, the ulcer size was 2.64±7.93 mm2 and 8.19±41.68 mm2 in tegoprazan and esomeprazole groups, respectively (p=0.761). The two groups showed no difference in changes in ulcer stages. A summary of the changes in ulcer stages can be found in Table 3.
Cumulative Healing Rates of Artificial Ulcers
Variable | Healing of the artificial ulcer (%) | Difference, % (95% CI) | p-value |
---|---|---|---|
4 wk | 8.20 (–6.07 to 22.48) | 0.006 | |
Tegoprazan group | 30.3 (23/76) | ||
Esomeprazole group | 22.1 (15/68) | ||
8 wk | –4.20 (–18.23 to 9.71) | 0.210 | |
Tegoprazan group | 73.7 (56/76) | ||
Esomeprazole group | 77.9 (53/68) |
Data are presented as percentages with number of subjects in parentheses, confidence interval (CI), non-inferiority margin –10%.
Changes in Ulcer Stages at 4 and 8 Weeks after ESD
Tegoprazan group (n=74) | Esomeprazole group (n=67) | |
---|---|---|
4 wk after ESD | ||
A1/A2 | 8 (10.8) | 10 (14.9) |
H1/H2 | 43 (58.1) | 42 (62.7) |
S1/S2 | 23 (31.1) | 15 (22.4) |
8 wk after ESD | ||
A1/A2 | 1 (1.4) | 2 (3.0) |
H1/H2 | 17 (23.0) | 12 (17.9) |
S1/S2 | 56 (75.7) | 53 (79.1) |
Data are presented as number (%).
ESD, endoscopic submucosal dissection.
At 4 weeks after ESD, the shrinkage rates of artificial ulcers were 85.6% in tegoprazan group and 85.0% in esomeprazole group, respectively (p=0.897). At 8 weeks after ESD, the shrinkage rates of artificial ulcers were 94.9% and 94.2% in the tegoprazan and esomeprazole groups, respectively (p=0.842).
Delayed bleeding occurred in two patients (2.6%) from the tegoprazan group and in one patient (1.5%) from the esomeprazole group (p=1.000). In all cases, melena was the first sign of delayed bleeding. One patient from the tegoprazan group experienced melena 9 days after ESD, and another patient from the same group had melena 14 days after ESD. One patient from the esomeprazole group had melena 10 days after ESD. Gastroscopy confirmed bleeding from the ESD site, with Forrest Ib observed in one patient from the esomeprazole group and Forrest IIa in two patients from the tegoprazan group. Delayed bleeding was successfully managed using endoscopic hemostasis in all the patients. Hemoglobin levels dropped from 2.1 g/dL to 3.2 g/dL.
Safety analysis was performed in 159 patients who received ≥1 dose of the study drug and underwent ≥1 safety assessment in this clinical trial. Among the 159 patients, 15 cases of TEAEs were reported in 12 patients. In the esomeprazole group only, one nausea, urticarial, and skin rash were reported as drug-related TEAEs (n=1, 1.28%).
The baseline serum gastrin levels were 94.99±105.78 pg/mL and 100.81±119.89 pg/mL for the tegoprazan and esomeprazole groups, respectively (Fig. 3). The serum gastrin levels were 82.14±70.5 pg/mL and 86.52±72.57 pg/mL at 4 weeks and 99.22±86.24 pg/mL and 96.21±81.65 pg/mL at 8 weeks for the tegoprazan and esomeprazole groups, respectively. The changes in serum gastrin levels did not differ significantly between the tegoprazan and esomeprazole groups.
In this study, we found that 50 mg of tegoprazan was not inferior to 40 mg of esomeprazole in treating artificial ulcers after ESD for gastric neoplasia. The healing rate of artificial ulcers at 4 weeks after ESD was higher in the tegoprazan group than in the esomeprazole group, whereas cumulative healing rate at 8 weeks after ESD did not show a significant difference between the two groups. From these results, it is plausible that tegoprazan has a more potent acid-suppressive effect than esomeprazole; therefore, the healing process after ESD progressed rapidly in the tegoprazan group. Some studies have observed that vonoprazan, another P-CAB, was superior to PPIs in the healing of artificial ulcers after ESD for gastric neoplasia, indicating similarities with our study.9,16 However, it is still uncertain whether P-CAB is superior to PPI in the healing of artificial ulcers after ESD for gastric neoplasia. A systematic review and meta-analysis showed that vonoprazan was superior to PPI at 4 weeks after ESD,17 whereas another recent systematic review and meta-analysis showed that there was no difference between vonoprazan and PPI.18
The healing rate of artificial ulcers at 4 weeks after administration of P-CABs or PPIs was reported to range from less than 10% to over 90% in various studies.16,19,20 This large variation among the studies might result from interpretation of H3 stage ulcers according to the Sakita-Miwa classification.21 In this study, the healing rates of artificial ulcers were 30.3% in the tegoprazan group and 22.1% in the esomeprazole group at 4 weeks after ESD. This result was similar to a recent study comparing the efficacy of vonoprazan and lansoprazole treatment for artificial ulcers.19 We strictly interpreted the ulcer stages and even minute ulcer bases were classified as healing stages. Additionally, the shrinkage rates of artificial ulcers should not be misinterpreted as complete healing. At 8 weeks after ESD, the artificial ulcers healed by more than 70% in both groups in this study. Considering these results, acid-reducing agents should be administered at least 8 weeks after ESD. Since cumulative ulcer healing rates at 8 weeks after ESD were not 100% in both groups, an adequate duration of acid-reducing agents used after ESD for gastric neoplasia should be elucidated in further studies.
Our study did not show any difference in delayed bleeding rates between the tegoprazan and esomeprazole groups. Delayed bleeding was not the main outcome of our study, and the number of patients enrolled in this study might not have been sufficient. Considering that most delayed bleeding occurs within a week after ESD,22 delayed bleeding may be preventable with more potent acid suppression. A large-scale prospective study is needed to elucidate the effect of tegoprazan on delayed bleeding.
Although P-CABs can overcome some of the unmet needs of PPIs, they still have some limitations in clinical practice. It is well known that serum gastrin levels might increase after administration of P-CABs.23 Tegoprazan has a different chemical structure than vonoprazan and revaprazan. There were no changes in the serum gastrin levels in either group in this study. This was similar to the results of previous studies.11,24 Therefore, tegoprazan might be safely administered for up to 8 weeks. Further studies with large numbers of patients are warranted.
The strength of this study is that it is a multicenter, randomized, double-blind, active-controlled study. Despite this strength, this is a non-inferiority study, and it cannot be concluded that 50 mg of tegoprazan is superior to 40 mg of esomeprazole in the healing of artificial ulcers after ESD for gastric neoplasia. Another limitation is that intravenous pantoprazole was administered for 48 hours before starting oral tegoprazan or esomeprazole because tegoprazan cannot be administered intravenously. Therefore, the immediate effect of tegoprazan after ESD was not evaluated in this study. Hemoglobin levels were not checked within 2 weeks after ESD, which may lead to underestimation of delayed bleeding occurrences.
In conclusion, this is the first study to investigate the effect of tegoprazan on the healing of artificial ulcers after ESD for gastric neoplasia. Tegoprazan showed a similar effect on post-ESD artificial ulcer healing in comparison to esomeprazole, constituting that tegoprazan can be a new option for the treatment of ESD-induced artificial ulcers.
This study was supported by HK Inno.N Corp. HK Inno.N provided financial support and study drug.
This study was supported by HK Inno.N Corp. HK Inno.N provided financial support and study drug. However, no role in the design of this study, study conduct, data analysis, and interpretation of the data.
B.W.K. and G.H.K. are editorial board members of the journal but were not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.
Study concept and design: J.J.P. Data acquisition: B.W.K., J.J.P., H.S.M., W.S.L., K.N.S., G.H.B., Y.J.L., H.L.L., Y.H.Y., J.C.P., I.K.S., H.C., J.S.M., G.H.K., S.J.H., H.S.C. Data analysis and interpretation: B.W.K. Drafting of the manuscript: B.W.K. Critical revision of the manuscript for important intellectual content: J.J.P., H.S.M., W.S.L., K.N.S., G.H.B., Y.J.L., H.L.L., Y.H.Y., J.C.P., I.K.S., H.C., J.S.M., G.H.K., S.J.H., H.S.C. Statistical analysis: B.W.K. Obtained funding: J.J.P. Study supervision: J.J.P.
Gut and Liver 2024; 18(2): 257-264
Published online March 15, 2024 https://doi.org/10.5009/gnl230242
Copyright © Gut and Liver.
Byung-Wook Kim1 , Jong Jae Park2 , Hee Seok Moon3 , Wan Sik Lee4 , Ki-Nam Shim5 , Gwang Ho Baik6 , Yun Jeong Lim7 , Hang Lak Lee8 , Young Hoon Youn9 , Jun Chul Park10 , In-Kyung Sung11 , Hyunsoo Chung12 , Jeong Seop Moon13 , Gwang Ha Kim14 , Su Jin Hong15 , Hyuk Soon Choi16
1Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea; 2Division of Gastroenterology, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea; 3Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea; 4Department of Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea; 5Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea; 6Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea; 7Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea; 8Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea; 9Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; 10Department of Gastroenterology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; 11Department of Internal Medicine, Konkuk University Medical Center, Konkuk University College of Medicine, Seoul, Korea; 12Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea; 13Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea; 14Department of Internal Medicine, Pusan National University College of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea; 15Digestive Disease Center and Research Institute, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea; 16Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea
Correspondence to:Jong Jae Park
ORCID https://orcid.org/0000-0002-4642-5405
E-mail gi7pjj@korea.ac.kr
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background/Aims: Tegoprazan is a novel potassium-competitive acid blocker that has beneficial effects on acid-related disorders such as gastroesophageal reflux and peptic ulcer diseases. This study aimed to validate the effect of tegoprazan on endoscopic submucosal dissection (ESD)-induced artificial ulcers.
Methods: Patients from 16 centers in Korea who underwent ESD for gastric neoplasia were enrolled. After ESD, pantoprazole was administered intravenously for 48 hours. The patients were randomly allocated to either the tegoprazan or esomeprazole group. Tegoprazan 50 mg or esomeprazole 40 mg were administered for 4 weeks, after which gastroscopic evaluation was performed. If the artificial ulcer had not healed, the same dose of tegoprazan or esomeprazole was administered for an additional 4 weeks, and a gastroscopic evaluation was performed.
Results: One hundred sixty patients were enrolled in this study. The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in the tegoprazan and esomeprazole groups, respectively (p=0.006). At 8 weeks after ESD, the cumulative ulcer healing rates were 73.7% (56/76) and 77.9% (53/68) in the tegoprazan and esomeprazole groups, respectively (p=0.210). Delayed bleeding occurred in two patients in the tegoprazan group (2.6%) and in one patient in the esomeprazole group (1.5%). Other adverse events were negligible in both groups.
Conclusions: Tegoprazan showed similar effects on post-ESD artificial ulcer healing in comparison with esomeprazole.
Keywords: Tegoprazan, Endoscopic resection, Endoscopic submucosal dissection, Gastric neoplasia, Multicenter prospective randomized study
Acid-reducing agents, such as proton pump inhibitors (PPIs), are administered after endoscopic submucosal dissection (ESD) for gastric neoplasia and non-ampullary duodenal tumors to avoid adverse events such as delayed bleeding.1-3 PPIs should be administered before meal; however, approximately half the patients do not take PPIs before breakfast,4 thus limiting their effects. Potassium-competitive acid blockers (P-CABs), which are novel acid-reducing agents, have been introduced to overcome the limitations of PPIs. P-CABs can be taken regardless of the meal times.
Vonoprazan, one of the P-CABs developed in Japan, has shown some benefits over PPIs in Helicobacter pylori eradication and the treatment of peptic ulcer diseases and gastroesophageal reflux diseases.5-7 Vonoprazan was also as effective as PPIs in preventing bleeding after ESD and healing of artificial ulcers after ESD for gastric neoplasia.8,9 Tegoprazan is a novel P-CAB developed in Korea that suppresses gastric acid secretion faster and more potently than PPIs.10 It is as effective as PPIs in the treatment of gastric ulcers and in H. pylori eradication.11,12 Tegoprazan is also effective in the treatment of gastroesophageal reflux diseases.13,14 However, the effect of tegoprazan in healing artificial ulcers after ESD is yet to be elucidated. This study aimed to evaluate the efficacy and safety of tegoprazan in the treatment of artificial ulcers after ESD in comparison to those of PPIs.
This study was a multicenter, randomized, double-blind, active-controlled, non-inferiority trial comparing tegoprazan (50 mg/day) and esomeprazole (40 mg/day). The study protocol was approved by the Korean Ministry of Food and Drug Safety (Registration number 32524) and the institutional review boards of each institution including Korea University Guro Hospital (IRB number: 2020GR0069). This study followed the Declaration of Helsinki and the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use‐Good Clinical Practice guidelines. Informed consent was obtained from all patients prior to enrollment. This study was registered at the Korean Disease Control and Prevention Agency registration site, Clinical Research Information Service (KCT0005470).
Drug distribution was determined according to the drug randomization number generated by an interactive web response system (cubeIWRS; CRScube Inc., Seoul, Korea). A double‐dummy method, using matching tegoprazan 50 mg and esomeprazole 40 mg, was employed to ensure that the study was double-blinded with key codes kept off-site by an external data manager. All medications were provided in sealed boxes and supplied by the medication supervisor to ensure blinded allocation. Blinded data were securely stored and could only be accessed by authorized personnel. All authors had access to the study data and reviewed and approved the final manuscript.
This study was performed at 16 centers in Korea. Inclusion criteria were as follows: patients aged 20 to 75 years who were diagnosed histologically and endoscopically with (1) gastric adenoma; (2) differentiated type gastric adenocarcinoma without ulcer; (3) differentiated type gastric adenocarcinoma with ulcer not involving submucosa less than 3.0 cm; (4) differentiated type gastric adenocarcinoma infiltrating submucosa less than 500 μm without ulcer less than 3.0 cm; and (5) undifferentiated type gastric adenocarcinoma not involving the submucosa without ulcer less than 2.0 cm. Exclusion criteria were as follows: (1) the size of artificial ulcer after ESD was over 4.0 cm; (2) overt bleeding or perforation after ESD; (3) past history of upper gastrointestinal tract surgery; (4) esophageal stricture, gastric outlet obstruction, or active peptic ulcer; (5) follow-up gastroscopy not available; (6) past history of adverse events to tegoprazan, PPI, or benzimidazole; (7) patients who were taking atazanavir, nelfinavir, rilpivirine, terfenadine, cisapride, pimozide, or astemizole; (8) pregnant or nursing women; (9) patients with uncontrolled cardiopulmonary diseases, renal diseases, liver diseases, neurologic diseases, or endocrine diseases including diabetes; (10) patients with cognition disorder or mental retardation; (11) patients who were taking anti-depressants, anxiolytics, or anti-psychotics; (12) patients who took PPI or H2 receptor antagonists within 2 weeks before ESD; (13) patients who were taking steroids, nonsteroidal anti-inflammatory drugs, aspirin, anti-platelet agents, or anticoagulants during the study period; (14) patients with aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, or bilirubin over 2 times the reference value; or (15) patients with blood urea nitrogen or creatinine over 1.5 times the reference value. Fasting serum gastrin level was checked on day zero and 4 and 8 weeks after ESD.
ESD was performed under conscious sedation. Sedative drugs were chosen by each endoscopist’s preference. A mixture of 0.001% epinephrine, 0.1% indigo carmine, and normal saline was injected into submucosal layer and mucosal cutting followed by submucosal dissection was performed using each endoscopist’s preference of knives. Hemorrhage during the procedure was controlled with hemostatic forceps. After ESD, the size of artificial ulcer was measured using biopsy forceps.
Immediately after ESD, a bolus of 80 mg pantoprazole was administered intravenously, followed by 8 mg per hour for 48 hours. Eligible patients were randomly assigned in a 1:1 ratio to receive either tegoprazan or esomeprazole during this period. Two days after ESD, the patients were instructed to take one tablet of 50 mg tegoprazan with one placebo esomeprazole tablet (tegoprazan group) or one placebo tegoprazan tablet with one tablet of 40 mg esomeprazole (esomeprazole group) once daily before breakfast for 4 weeks. Gastroscopic evaluation was performed 4 weeks after ESD. When an artificial ulcer was found in the active or healing stage according to Sakita-Miwa’s classification on gastroscopy 4 weeks after ESD, 50 mg tegoprazan with placebo or 40 mg esomeprazole with placebo was administered 4 weeks more. In these patients, gastroscopic evaluation was performed again 8 weeks after ESD. The study process is illustrated in Fig. 1.
The primary endpoint of this study was the healing rates of ESD-induced artificial ulcers at 4 and 8 weeks. The secondary endpoints were as follows: (1) healing rates of ESD-induced artificial ulcers at 4 weeks and 8 weeks; (2) change in ulcer size; and (3) the incidence of delayed bleeding. Healing of ESD-induced artificial ulcer was defined as the complete closure of the mucosal defect. The ulcer size was measured as follows: the mucosal defect after ESD was considered elliptical, and the area was calculated by multiplying the long axis radius and the short axis radius, followed by multiplying π, and expressed in mm2. The shrinkage rates of the artificial ulcers at 4 and 8 weeks were also compared as an exploratory endpoint. The shrinkage rate of artificial ulcers was calculated as the ratio of ulcer size at 4 and 8 weeks to the ulcer size immediately after ESD. The size of the artificial ulcer was measured using opening biopsy forceps. Delayed bleeding was defined by overt hemorrhage signs such as hematemesis or melena over 24 hours after initiating either tegoprazan or esomeprazole along with a decrease in hemoglobin level of over 2.0 g/dL.
Safety was evaluated using vital signs (blood pressure, heart rate, and body temperature), physical examination, serum gastrin level, and incidence of treatment-emergent adverse events (TEAEs). A TEAE was defined as an adverse event that occurred after the participant received the study drug. TEAEs were categorized by severity and relativity and compared between the treatment groups. Adverse events were analyzed in the safety set.
For sample size calculation, the healing rate of artificial ulcers at 8 weeks was assumed to be 95.5% for tegoprazan and esomeprazole, with a non-inferiority margin of –10% and a power of 80% at a significant level of 2.5% (one-sided).15 While a direct comparison between vonoprazan and tegoprazan for artificial ulcer healing is lacking, an indirect comparison was conducted using data from reports. Specifically, it was found that vonoprazan exhibited comparable effectiveness to lansoprazole in healing gastric ulcers (93.5% for vonoprazan and 93.8% for lansoprazole), and similarly, tegoprazan demonstrated comparable efficacy to lansoprazole in gastric ulcer healing (95.0% for tegoprazan and 95.7% for lansoprazole).6,11 The total sample size was 160 subjects, with 80 patients per treatment group, considering a 15% drop-out.
For continuous variables, the values are provided as the number of subjects, mean, standard deviation, median, minimum and maximum. For categorical variables, the values are presented as frequencies and percentages. The non-inferiority test of tegoprazan versus esomeprazole in healing rate was to be declared if the lower bound of the two-sided 95% confidence interval for the difference between the two arms was greater than the non-inferiority margin, –10%. Continuous variables were compared by the Student t-test or Wilcoxon rank-sum test depending on whether the normality assumption was satisfied. Categorical variables were compared by the chi-square test or Fisher exact test depending on whether 20% or more of cells with an expected frequency of 5 or less were found.
All two-sided statistical tests were performed at a significance level of 5% unless otherwise specified. Statistical analyses were performed using SAS 9.4 (SAS Institution Inc., Cary, NC, USA).
Among the 167 patients with an artificial ulcer after ESD who were screened, three were ineligible based on the inclusion/exclusion criteria, and four withdrew their consent. These participants were considered to have screening failure, and the remaining 160 patients were randomized in a 1:1 ratio to one of the two treatment arms: tegoprazan or esomeprazole. Among the 160 randomized patients, 16 (10.0%) were discontinued from the study due to the lack of viable data (n=10, 6.3%), violation of an inclusion/exclusion criteria (n=5, 3.1%), or withdrawal of consent before exposure to the study drug (n=1, 0.6%) (Fig. 2). The baseline characteristics of the patients are summarized in Table 1. No significant differences in baseline characteristics were observed between the treatment groups.
Baseline Characteristic of Patients in the Full Analysis Set.
Characteristic | Tegoprazan group (n=76) | Esomeprazole group (n=68) |
---|---|---|
Sex, No. (%) | ||
Male | 57 (75.0) | 46 (67.7) |
Female | 19 (25.0) | 22 (32.3) |
Age, mean±SD, yr | 62.0±7.4 | 63.0±7.8 |
Social history, No. (%) | ||
Smoking | 16 (21.1) | 9 (13.2) |
Alcohol | 29 (38.2) | 18 (26.5) |
Pre-procedural histology, No. (%) | ||
Adenoma, low grade dysplasia | 41 (54.0) | 37 (54.4) |
Adenoma, high grade dysplasia | 13 (17.1) | 13 (19.1) |
Differentiated adenocarcinoma | 17 (22.4) | 17 (25.0) |
Undifferentiated adenocarcinoma | 2 (2.6) | 1 (1.5) |
Mixed | 3 (4.0) | 0 |
Ulcer size immediately after ESD, mean±SD, mm2 | 507.1±277.7 | 562.9±324.8 |
ESD, endoscopic submucosal dissection..
The healing rates of artificial ulcers at 4 weeks were 30.3% (23/76) and 22.1% (15/68) in tegoprazan group and in esomeprazole group, respectively. The percentage difference between the tegoprazan group and esomeprazole group was <–10% (95% confidence interval, –6.07 to 22.48), which confirmed the non-inferiority of the tegoprazan group in comparison to the esomeprazole group. At 8 weeks after ESD, the cumulative healing rates of artificial ulcers were 73.7% (56/76) and 77.9% (53/68) in tegoprazan and esomeprazole groups, respectively (95% confidence interval, –18.23 to 9.71). The results are summarized in Table 2. Immediately after ESD, the ulcer size was 508.18±274.10 mm2 and 585.63±309.72 mm2 in tegoprazan group and esomeprazole groups, respectively (p=0.180). Four weeks after ESD, the ulcer size was 51.63±75.06 mm2 and 60.26±79.51 mm2 in tegoprazan and esomeprazole groups, respectively (p=0.400). Eight weeks after ESD, the ulcer size was 2.64±7.93 mm2 and 8.19±41.68 mm2 in tegoprazan and esomeprazole groups, respectively (p=0.761). The two groups showed no difference in changes in ulcer stages. A summary of the changes in ulcer stages can be found in Table 3.
Cumulative Healing Rates of Artificial Ulcers.
Variable | Healing of the artificial ulcer (%) | Difference, % (95% CI) | p-value |
---|---|---|---|
4 wk | 8.20 (–6.07 to 22.48) | 0.006 | |
Tegoprazan group | 30.3 (23/76) | ||
Esomeprazole group | 22.1 (15/68) | ||
8 wk | –4.20 (–18.23 to 9.71) | 0.210 | |
Tegoprazan group | 73.7 (56/76) | ||
Esomeprazole group | 77.9 (53/68) |
Data are presented as percentages with number of subjects in parentheses, confidence interval (CI), non-inferiority margin –10%..
Changes in Ulcer Stages at 4 and 8 Weeks after ESD.
Tegoprazan group (n=74) | Esomeprazole group (n=67) | |
---|---|---|
4 wk after ESD | ||
A1/A2 | 8 (10.8) | 10 (14.9) |
H1/H2 | 43 (58.1) | 42 (62.7) |
S1/S2 | 23 (31.1) | 15 (22.4) |
8 wk after ESD | ||
A1/A2 | 1 (1.4) | 2 (3.0) |
H1/H2 | 17 (23.0) | 12 (17.9) |
S1/S2 | 56 (75.7) | 53 (79.1) |
Data are presented as number (%)..
ESD, endoscopic submucosal dissection..
At 4 weeks after ESD, the shrinkage rates of artificial ulcers were 85.6% in tegoprazan group and 85.0% in esomeprazole group, respectively (p=0.897). At 8 weeks after ESD, the shrinkage rates of artificial ulcers were 94.9% and 94.2% in the tegoprazan and esomeprazole groups, respectively (p=0.842).
Delayed bleeding occurred in two patients (2.6%) from the tegoprazan group and in one patient (1.5%) from the esomeprazole group (p=1.000). In all cases, melena was the first sign of delayed bleeding. One patient from the tegoprazan group experienced melena 9 days after ESD, and another patient from the same group had melena 14 days after ESD. One patient from the esomeprazole group had melena 10 days after ESD. Gastroscopy confirmed bleeding from the ESD site, with Forrest Ib observed in one patient from the esomeprazole group and Forrest IIa in two patients from the tegoprazan group. Delayed bleeding was successfully managed using endoscopic hemostasis in all the patients. Hemoglobin levels dropped from 2.1 g/dL to 3.2 g/dL.
Safety analysis was performed in 159 patients who received ≥1 dose of the study drug and underwent ≥1 safety assessment in this clinical trial. Among the 159 patients, 15 cases of TEAEs were reported in 12 patients. In the esomeprazole group only, one nausea, urticarial, and skin rash were reported as drug-related TEAEs (n=1, 1.28%).
The baseline serum gastrin levels were 94.99±105.78 pg/mL and 100.81±119.89 pg/mL for the tegoprazan and esomeprazole groups, respectively (Fig. 3). The serum gastrin levels were 82.14±70.5 pg/mL and 86.52±72.57 pg/mL at 4 weeks and 99.22±86.24 pg/mL and 96.21±81.65 pg/mL at 8 weeks for the tegoprazan and esomeprazole groups, respectively. The changes in serum gastrin levels did not differ significantly between the tegoprazan and esomeprazole groups.
In this study, we found that 50 mg of tegoprazan was not inferior to 40 mg of esomeprazole in treating artificial ulcers after ESD for gastric neoplasia. The healing rate of artificial ulcers at 4 weeks after ESD was higher in the tegoprazan group than in the esomeprazole group, whereas cumulative healing rate at 8 weeks after ESD did not show a significant difference between the two groups. From these results, it is plausible that tegoprazan has a more potent acid-suppressive effect than esomeprazole; therefore, the healing process after ESD progressed rapidly in the tegoprazan group. Some studies have observed that vonoprazan, another P-CAB, was superior to PPIs in the healing of artificial ulcers after ESD for gastric neoplasia, indicating similarities with our study.9,16 However, it is still uncertain whether P-CAB is superior to PPI in the healing of artificial ulcers after ESD for gastric neoplasia. A systematic review and meta-analysis showed that vonoprazan was superior to PPI at 4 weeks after ESD,17 whereas another recent systematic review and meta-analysis showed that there was no difference between vonoprazan and PPI.18
The healing rate of artificial ulcers at 4 weeks after administration of P-CABs or PPIs was reported to range from less than 10% to over 90% in various studies.16,19,20 This large variation among the studies might result from interpretation of H3 stage ulcers according to the Sakita-Miwa classification.21 In this study, the healing rates of artificial ulcers were 30.3% in the tegoprazan group and 22.1% in the esomeprazole group at 4 weeks after ESD. This result was similar to a recent study comparing the efficacy of vonoprazan and lansoprazole treatment for artificial ulcers.19 We strictly interpreted the ulcer stages and even minute ulcer bases were classified as healing stages. Additionally, the shrinkage rates of artificial ulcers should not be misinterpreted as complete healing. At 8 weeks after ESD, the artificial ulcers healed by more than 70% in both groups in this study. Considering these results, acid-reducing agents should be administered at least 8 weeks after ESD. Since cumulative ulcer healing rates at 8 weeks after ESD were not 100% in both groups, an adequate duration of acid-reducing agents used after ESD for gastric neoplasia should be elucidated in further studies.
Our study did not show any difference in delayed bleeding rates between the tegoprazan and esomeprazole groups. Delayed bleeding was not the main outcome of our study, and the number of patients enrolled in this study might not have been sufficient. Considering that most delayed bleeding occurs within a week after ESD,22 delayed bleeding may be preventable with more potent acid suppression. A large-scale prospective study is needed to elucidate the effect of tegoprazan on delayed bleeding.
Although P-CABs can overcome some of the unmet needs of PPIs, they still have some limitations in clinical practice. It is well known that serum gastrin levels might increase after administration of P-CABs.23 Tegoprazan has a different chemical structure than vonoprazan and revaprazan. There were no changes in the serum gastrin levels in either group in this study. This was similar to the results of previous studies.11,24 Therefore, tegoprazan might be safely administered for up to 8 weeks. Further studies with large numbers of patients are warranted.
The strength of this study is that it is a multicenter, randomized, double-blind, active-controlled study. Despite this strength, this is a non-inferiority study, and it cannot be concluded that 50 mg of tegoprazan is superior to 40 mg of esomeprazole in the healing of artificial ulcers after ESD for gastric neoplasia. Another limitation is that intravenous pantoprazole was administered for 48 hours before starting oral tegoprazan or esomeprazole because tegoprazan cannot be administered intravenously. Therefore, the immediate effect of tegoprazan after ESD was not evaluated in this study. Hemoglobin levels were not checked within 2 weeks after ESD, which may lead to underestimation of delayed bleeding occurrences.
In conclusion, this is the first study to investigate the effect of tegoprazan on the healing of artificial ulcers after ESD for gastric neoplasia. Tegoprazan showed a similar effect on post-ESD artificial ulcer healing in comparison to esomeprazole, constituting that tegoprazan can be a new option for the treatment of ESD-induced artificial ulcers.
This study was supported by HK Inno.N Corp. HK Inno.N provided financial support and study drug.
This study was supported by HK Inno.N Corp. HK Inno.N provided financial support and study drug. However, no role in the design of this study, study conduct, data analysis, and interpretation of the data.
B.W.K. and G.H.K. are editorial board members of the journal but were not involved in the peer reviewer selection, evaluation, or decision process of this article. No other potential conflicts of interest relevant to this article were reported.
Study concept and design: J.J.P. Data acquisition: B.W.K., J.J.P., H.S.M., W.S.L., K.N.S., G.H.B., Y.J.L., H.L.L., Y.H.Y., J.C.P., I.K.S., H.C., J.S.M., G.H.K., S.J.H., H.S.C. Data analysis and interpretation: B.W.K. Drafting of the manuscript: B.W.K. Critical revision of the manuscript for important intellectual content: J.J.P., H.S.M., W.S.L., K.N.S., G.H.B., Y.J.L., H.L.L., Y.H.Y., J.C.P., I.K.S., H.C., J.S.M., G.H.K., S.J.H., H.S.C. Statistical analysis: B.W.K. Obtained funding: J.J.P. Study supervision: J.J.P.
Baseline Characteristic of Patients in the Full Analysis Set
Characteristic | Tegoprazan group (n=76) | Esomeprazole group (n=68) |
---|---|---|
Sex, No. (%) | ||
Male | 57 (75.0) | 46 (67.7) |
Female | 19 (25.0) | 22 (32.3) |
Age, mean±SD, yr | 62.0±7.4 | 63.0±7.8 |
Social history, No. (%) | ||
Smoking | 16 (21.1) | 9 (13.2) |
Alcohol | 29 (38.2) | 18 (26.5) |
Pre-procedural histology, No. (%) | ||
Adenoma, low grade dysplasia | 41 (54.0) | 37 (54.4) |
Adenoma, high grade dysplasia | 13 (17.1) | 13 (19.1) |
Differentiated adenocarcinoma | 17 (22.4) | 17 (25.0) |
Undifferentiated adenocarcinoma | 2 (2.6) | 1 (1.5) |
Mixed | 3 (4.0) | 0 |
Ulcer size immediately after ESD, mean±SD, mm2 | 507.1±277.7 | 562.9±324.8 |
ESD, endoscopic submucosal dissection.
Cumulative Healing Rates of Artificial Ulcers
Variable | Healing of the artificial ulcer (%) | Difference, % (95% CI) | p-value |
---|---|---|---|
4 wk | 8.20 (–6.07 to 22.48) | 0.006 | |
Tegoprazan group | 30.3 (23/76) | ||
Esomeprazole group | 22.1 (15/68) | ||
8 wk | –4.20 (–18.23 to 9.71) | 0.210 | |
Tegoprazan group | 73.7 (56/76) | ||
Esomeprazole group | 77.9 (53/68) |
Data are presented as percentages with number of subjects in parentheses, confidence interval (CI), non-inferiority margin –10%.
Changes in Ulcer Stages at 4 and 8 Weeks after ESD
Tegoprazan group (n=74) | Esomeprazole group (n=67) | |
---|---|---|
4 wk after ESD | ||
A1/A2 | 8 (10.8) | 10 (14.9) |
H1/H2 | 43 (58.1) | 42 (62.7) |
S1/S2 | 23 (31.1) | 15 (22.4) |
8 wk after ESD | ||
A1/A2 | 1 (1.4) | 2 (3.0) |
H1/H2 | 17 (23.0) | 12 (17.9) |
S1/S2 | 56 (75.7) | 53 (79.1) |
Data are presented as number (%).
ESD, endoscopic submucosal dissection.