Article Search
검색
검색 팝업 닫기

Metrics

Help

  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

  • 2. Editorial Board

    Editor-in-Chief + MORE

    Editor-in-Chief
    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
  • 3. Editorial Office
  • 4. Articles
  • 5. Instructions for Authors
  • 6. File Download (PDF version)
  • 7. Ethical Standards
  • 8. Peer Review

    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
    The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.

    The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.

Search

Search

Year

to

Article Type

ahead

Split Viewer

Online first

Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study

Jongwook Yu1 , Soo Jung Park1 , Hyung Wook Kim2 , Yun Jeong Lim3 , Jihye Park1,4 , Jae Myung Cha5 , Byong Duk Ye6 , Tae Oh Kim7 , Hyun-Soo Kim8 , Hyun Seok Lee9,10 , Su Young Jung11 , Youngdoe Kim11 , and Chang Hwan Choi12

1Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, 2Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, 3Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, 4Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 5Department of Internal Medicine, Kyung Hee University School of Medicine, 6Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 7Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 8Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, 9Department of Internal Medicine, School of Medicine, Kyungpook National University, 10Kyungpook National University Hospital, Daegu, 11Medical Affairs, Janssen Korea Ltd., and 12Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea

Correspondence to:Chang Hwan Choi
ORCID https://orcid.org/0000-0001-7089-532X
E-mail gicch@cau.ac.kr

Jongwook Yu and Soo Jung Park contributed equally to this work as first authors.

Received: July 20, 2021; Revised: October 20, 2021; Accepted: October 21, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gut Liver

Published online December 27, 2021

Copyright © Gut and Liver.

Abstract

Background/Aims: Golimumab has been used for patients with ulcerative colitis (UC) since 2013. However, there is limited data on the effectiveness and safety of the real-world use of golimumab in Asian patients.
Methods: This was a multicenter, prospective, observational study. We enrolled patients with moderate-to-severe UC who were administered subcutaneous golimumab at 46 medical centers between May 2014 and November 2019. The primary outcome was the effectiveness and safety of golimumab at week 22. Clinical outcomes and adverse events were assessed according to partial Mayo score at weeks 0, 2, 6, 14, and 22.
Results: A total of 130 patients were included (mean age: 45.7±16.0 years). The clinical response/ remission rates at weeks 2, 6, 14, and 22 were 40.4%/22.9%, 56.0%/35.8%, 70.6%/49.5%, and 67.9%/48.6%, respectively. Based on full Mayo score at week 14, clinical response and remission rates were 84.2% and 39.5%, respectively. Mucosal healing rate was 65.8%. In multivariate analysis with logistic regression, longer disease duration was significantly associated with a higher clinical response rate (adjusted odds ratio [aOR], 1.136; 95% confidence interval [CI], 1.006 to 1.282; p=0.040 at week 6; aOR, 1.256; 95% CI, 1.049 to 1.503; p=0.013 at week 22). A higher baseline Mayo endoscopic subscore was significantly associated with a lower clinical response rate at week 6 (aOR, 0.248; 95% CI, 0.089 to 0.692; p=0.008). The incidence of adverse drug reactions was 4.6% (6/130, nine events). No serious unexpected adverse drug reactions or deaths were reported.
Conclusions: Golimumab was effective and safe as an induction and maintenance treatment for Korean patients with moderate-to-severe UC.

Keywords: Ulcerative colitis, Golimumab, Tumor necrosis factor-α


Article

ahead

Gut and Liver

Published online December 27, 2021

Copyright © Gut and Liver.

Effectiveness and Safety of Golimumab in Patients with Ulcerative Colitis: A Multicenter, Prospective, Postmarketing Surveillance Study

Jongwook Yu1 , Soo Jung Park1 , Hyung Wook Kim2 , Yun Jeong Lim3 , Jihye Park1,4 , Jae Myung Cha5 , Byong Duk Ye6 , Tae Oh Kim7 , Hyun-Soo Kim8 , Hyun Seok Lee9,10 , Su Young Jung11 , Youngdoe Kim11 , and Chang Hwan Choi12

1Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, 2Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, 3Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, 4Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 5Department of Internal Medicine, Kyung Hee University School of Medicine, 6Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 7Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 8Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, 9Department of Internal Medicine, School of Medicine, Kyungpook National University, 10Kyungpook National University Hospital, Daegu, 11Medical Affairs, Janssen Korea Ltd., and 12Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea

Correspondence to:Chang Hwan Choi
ORCID https://orcid.org/0000-0001-7089-532X
E-mail gicch@cau.ac.kr

Jongwook Yu and Soo Jung Park contributed equally to this work as first authors.

Received: July 20, 2021; Revised: October 20, 2021; Accepted: October 21, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims: Golimumab has been used for patients with ulcerative colitis (UC) since 2013. However, there is limited data on the effectiveness and safety of the real-world use of golimumab in Asian patients.
Methods: This was a multicenter, prospective, observational study. We enrolled patients with moderate-to-severe UC who were administered subcutaneous golimumab at 46 medical centers between May 2014 and November 2019. The primary outcome was the effectiveness and safety of golimumab at week 22. Clinical outcomes and adverse events were assessed according to partial Mayo score at weeks 0, 2, 6, 14, and 22.
Results: A total of 130 patients were included (mean age: 45.7±16.0 years). The clinical response/ remission rates at weeks 2, 6, 14, and 22 were 40.4%/22.9%, 56.0%/35.8%, 70.6%/49.5%, and 67.9%/48.6%, respectively. Based on full Mayo score at week 14, clinical response and remission rates were 84.2% and 39.5%, respectively. Mucosal healing rate was 65.8%. In multivariate analysis with logistic regression, longer disease duration was significantly associated with a higher clinical response rate (adjusted odds ratio [aOR], 1.136; 95% confidence interval [CI], 1.006 to 1.282; p=0.040 at week 6; aOR, 1.256; 95% CI, 1.049 to 1.503; p=0.013 at week 22). A higher baseline Mayo endoscopic subscore was significantly associated with a lower clinical response rate at week 6 (aOR, 0.248; 95% CI, 0.089 to 0.692; p=0.008). The incidence of adverse drug reactions was 4.6% (6/130, nine events). No serious unexpected adverse drug reactions or deaths were reported.
Conclusions: Golimumab was effective and safe as an induction and maintenance treatment for Korean patients with moderate-to-severe UC.

Keywords: Ulcerative colitis, Golimumab, Tumor necrosis factor-α

Gut and Liver

Vol.16 No.1
January, 2022

pISSN 1976-2283
eISSN 2005-1212

qrcode
qrcode

Share this article on :

  • line

Popular Keywords

Gut and LiverQR code Download
qr-code

Editorial Office