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  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

  • 2. Editorial Board

    Editor-in-Chief + MORE

    Editor-in-Chief
    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
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  • 8. Peer Review

    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
    The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.

    The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.

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The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis

Fumin Xu1 , Chunmei Yang1 , Mingcheng Tang1 , Ming Wang1 , Zhenhao Cheng1 , Dongfeng Chen1 , Xiao Chen2 , and Kaijun Liu1

Departments of 1Gastroenterology and 2Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing, China

Correspondence to:Kaijun Liu
ORCID https://orcid.org/0000-0003-0027-9278
E-mail kliu_tmmu@126.com
Xiao Chen
ORCID https://orcid.org/0000-0002-8647-0614
E-mail xiaochen229@foxmail.com
Fumin Xu and Chunmei Yang contributed equally to this work as first authors.

Received: August 9, 2021; Revised: September 6, 2021; Accepted: September 17, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gut Liver

Published online December 16, 2021

Copyright © Gut and Liver.

Abstract

Pancreatitis is one of the most common inflammatory diseases of the pancreas caused by autodigestion induced by excessive premature protease activation. However, recognition of novel pathophysiological mechanisms remains a still challenge. Both genetic and environmental factors contribute to the pathogenesis of pancreatitis, and the gut microbiota is a potential source of an environmental effect. In recent years, several new frontiers in gut microbiota and genetic risk assessment research have emerged and improved the understanding of the disease. These investigations showed that the disease progression of pancreatitis could be regulated by the gut microbiome, either through a translocation influence or in a host immune response manner. Meanwhile, the onset of the disease is also associated with the heritage of a pathogenic mutation, and the disease progression could be modified by genetic risk factors. In this review, we focused on the recent advances in the role of gut microbiota in the pathogenesis of pancreatitis, and the genetic susceptibility in pancreatitis.

Keywords: Pancreatitis, Gut microbiota, Genetic susceptibility, Pathogenesis


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Gut and Liver

Published online December 16, 2021

Copyright © Gut and Liver.

The Role of Gut Microbiota and Genetic Susceptibility in the Pathogenesis of Pancreatitis

Fumin Xu1 , Chunmei Yang1 , Mingcheng Tang1 , Ming Wang1 , Zhenhao Cheng1 , Dongfeng Chen1 , Xiao Chen2 , and Kaijun Liu1

Departments of 1Gastroenterology and 2Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing, China

Correspondence to:Kaijun Liu
ORCID https://orcid.org/0000-0003-0027-9278
E-mail kliu_tmmu@126.com
Xiao Chen
ORCID https://orcid.org/0000-0002-8647-0614
E-mail xiaochen229@foxmail.com
Fumin Xu and Chunmei Yang contributed equally to this work as first authors.

Received: August 9, 2021; Revised: September 6, 2021; Accepted: September 17, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pancreatitis is one of the most common inflammatory diseases of the pancreas caused by autodigestion induced by excessive premature protease activation. However, recognition of novel pathophysiological mechanisms remains a still challenge. Both genetic and environmental factors contribute to the pathogenesis of pancreatitis, and the gut microbiota is a potential source of an environmental effect. In recent years, several new frontiers in gut microbiota and genetic risk assessment research have emerged and improved the understanding of the disease. These investigations showed that the disease progression of pancreatitis could be regulated by the gut microbiome, either through a translocation influence or in a host immune response manner. Meanwhile, the onset of the disease is also associated with the heritage of a pathogenic mutation, and the disease progression could be modified by genetic risk factors. In this review, we focused on the recent advances in the role of gut microbiota in the pathogenesis of pancreatitis, and the genetic susceptibility in pancreatitis.

Keywords: Pancreatitis, Gut microbiota, Genetic susceptibility, Pathogenesis

Gut and Liver

Vol.16 No.1
January, 2022

pISSN 1976-2283
eISSN 2005-1212

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