Article Search
검색
검색 팝업 닫기

Metrics

Help

  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

  • 2. Editorial Board

    Editor-in-Chief + MORE

    Editor-in-Chief
    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
  • 3. Editorial Office
  • 4. Articles
  • 5. Instructions for Authors
  • 6. File Download (PDF version)
  • 7. Ethical Standards
  • 8. Peer Review

    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
    The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.

    The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.

Search

Search

Year

to

Article Type

ahead

Split Viewer

Online first

Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa- Kangdong District of Seoul, Korea

Sang Hyoung Park1 , Seung Kyu Jeong2 , Ji Hyun Lee3 , Kyoung Hoon Rhee4 , Young-Ho Kim5 , Sung Noh Hong5 , Kyung Ho Kim6 , Seung In Seo6 , Jae Myung Cha7 , Sun Yong Park8 , Hyunju Park9 , Joo Sung Kim10 , Jong Pil Im10 , Hyuk Yoon11 , Sung Hoon Kim12 , Jisun Jang12 , Jeong Hwan Kim13 , Seong O Suh14 , Young Kyun Kim15 , Byong Duk Ye1 , and Suk-Kyun Yang1 , on behalf of the Songpa-Kangdong Inflammatory Bowel Disease (SK-IBD) Study Group

1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 2Department of Surgery, Yang Hospital, 3Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, 4Department of Internal Medicine, Hansol Hospital, 5Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 6Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 7Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, 8Kangdong Seoul Colon and Rectal Surgery, 9Department of Gastroenterology, Daehang Hospital, 10Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, 11Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 12Department of Internal Medicine, VHS Medical Center, 13Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 14Department of Internal Medicine, National Police Hospital, and 15Jamsil Seoul Surgical Clinic, Seoul, Korea

Correspondence to:Suk-Kyun Yang
ORCID https://orcid.org/0000-0003-2772-2575
E-mail sky@amc.seoul.kr

Sang Hyoung Park, Seung Kyu Jeong, and Ji Hyun Lee contributed equally to this work as first authors.

Received: September 11, 2020; Revised: November 17, 2020; Accepted: November 17, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gut and Liver

Published online January 19, 2021

Copyright © Gut and Liver.

Abstract

Background/Aims: We aimed to evaluate the clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using a wellestablished population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
Methods: Clinical characteristics and prognosis were compared between two groups: EOUC, defined as UC diagnosed in individuals aged ≥60 years and non-EOUC (N-EOUC), defined as UC diagnosed in individuals aged 18 to 59 years.
Results: We identified 99 patients with EOUC (10.3%) and 866 patients with N-EOUC (89.7%) between 1986 and 2015. During the median follow-up of 104.5 months, the overall exposure to medications was comparable between patients with EOUC and N-EOUC (p=0.091 for corticosteroids, p=0.794 for thiopurines, and p=0.095 for anti-tumor necrosis factor agents). The cumulative risks of disease outcomes were also comparable between patients with EOUC and N-EOUC (22.4% vs 30.4% for proximal disease extension [p=0.351], 11.9% vs 18.1% for hospitalization [p=0.240], and 2.3% vs 1.8% for colectomy [p=0.977]) at 10 years after diagnosis. Multivariate Cox regression analysis revealed that corticosteroid use at diagnosis was an independent predictor of proximal disease extension (hazard ratio [HR], 6.216; 95% confidence interval [CI], 1.314 to 28.826) and hospitalization (HR, 11.241; 95% CI, 3.027 to 41.742) in patients with EOUC.
Conclusions: In this population-based study from Korea, the pattern of medication use seemed comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those with N-EOUC have a similar disease course in terms of proximal disease extension, hospitalization, and colectomy.

Keywords: Colitis, ulcerative, Aged, Prognosis, Korea


Article

ahead

Gut and Liver

Published online January 19, 2021

Copyright © Gut and Liver.

Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa- Kangdong District of Seoul, Korea

Sang Hyoung Park1 , Seung Kyu Jeong2 , Ji Hyun Lee3 , Kyoung Hoon Rhee4 , Young-Ho Kim5 , Sung Noh Hong5 , Kyung Ho Kim6 , Seung In Seo6 , Jae Myung Cha7 , Sun Yong Park8 , Hyunju Park9 , Joo Sung Kim10 , Jong Pil Im10 , Hyuk Yoon11 , Sung Hoon Kim12 , Jisun Jang12 , Jeong Hwan Kim13 , Seong O Suh14 , Young Kyun Kim15 , Byong Duk Ye1 , and Suk-Kyun Yang1 , on behalf of the Songpa-Kangdong Inflammatory Bowel Disease (SK-IBD) Study Group

1Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 2Department of Surgery, Yang Hospital, 3Digestive Endoscopic Center, Seoul Song Do Colorectal Hospital, 4Department of Internal Medicine, Hansol Hospital, 5Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 6Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 7Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, 8Kangdong Seoul Colon and Rectal Surgery, 9Department of Gastroenterology, Daehang Hospital, 10Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, 11Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, 12Department of Internal Medicine, VHS Medical Center, 13Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, 14Department of Internal Medicine, National Police Hospital, and 15Jamsil Seoul Surgical Clinic, Seoul, Korea

Correspondence to:Suk-Kyun Yang
ORCID https://orcid.org/0000-0003-2772-2575
E-mail sky@amc.seoul.kr

Sang Hyoung Park, Seung Kyu Jeong, and Ji Hyun Lee contributed equally to this work as first authors.

Received: September 11, 2020; Revised: November 17, 2020; Accepted: November 17, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims: We aimed to evaluate the clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period using a wellestablished population-based cohort in the Songpa-Kangdong district of Seoul, Korea.
Methods: Clinical characteristics and prognosis were compared between two groups: EOUC, defined as UC diagnosed in individuals aged ≥60 years and non-EOUC (N-EOUC), defined as UC diagnosed in individuals aged 18 to 59 years.
Results: We identified 99 patients with EOUC (10.3%) and 866 patients with N-EOUC (89.7%) between 1986 and 2015. During the median follow-up of 104.5 months, the overall exposure to medications was comparable between patients with EOUC and N-EOUC (p=0.091 for corticosteroids, p=0.794 for thiopurines, and p=0.095 for anti-tumor necrosis factor agents). The cumulative risks of disease outcomes were also comparable between patients with EOUC and N-EOUC (22.4% vs 30.4% for proximal disease extension [p=0.351], 11.9% vs 18.1% for hospitalization [p=0.240], and 2.3% vs 1.8% for colectomy [p=0.977]) at 10 years after diagnosis. Multivariate Cox regression analysis revealed that corticosteroid use at diagnosis was an independent predictor of proximal disease extension (hazard ratio [HR], 6.216; 95% confidence interval [CI], 1.314 to 28.826) and hospitalization (HR, 11.241; 95% CI, 3.027 to 41.742) in patients with EOUC.
Conclusions: In this population-based study from Korea, the pattern of medication use seemed comparable between the EOUC and N-EOUC groups. Moreover, patients with EOUC and those with N-EOUC have a similar disease course in terms of proximal disease extension, hospitalization, and colectomy.

Keywords: Colitis, ulcerative, Aged, Prognosis, Korea

Gut and Liver

Vol.15 No.3
May, 2021

pISSN 1976-2283
eISSN 2005-1212

qrcode
qrcode

Share this article on :

  • line

Popular Keywords

Gut and LiverQR code Download
qr-code

Editorial Office