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  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

  • 2. Editorial Board

    Editor-in-Chief + MORE

    Editor-in-Chief
    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
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    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
    The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.

    The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.

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Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?

Dexi Zhou1,2,3 , Jiajie Luan1,2,3 , Cheng Huang4 , and Jun Li4

1Department of Pharmacy, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, 2Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution and 3School of Pharmacy, Wannan Medical College, Wuhu, and 4School of Pharmacy, Anhui Medical University, Hefei, China

Correspondence to:Jun Li
School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China
Tel: +86-551-65739915, Fax: +86-551-65739915, E-mail: lijun@ahmu.edu.cn

Received: July 17, 2020; Revised: August 21, 2020; Accepted: August 22, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gut and Liver

Published online October 23, 2020

Copyright © Gut and Liver.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at advanced stages when there are limited therapeutic options. Hepatocarcinogenesis is considered a multistep process, and hepatic macrophages play a critical role in the inflammatory process leading to HCC. Emerging evidence has shown that tumor-associated macrophages (TAMs) are crucial components defining the HCC immune microenvironment and represent an appealing option for disrupting the formation and development of HCC. In this review, we summarize the current knowledge of the polarization and function of TAMs in the pathogenesis of HCC, as well as the mechanisms underlying TAM-related anti-HCC therapies. Eventually, novel insights into these important aspects of TAMs and their roles in the HCC microenvironment might lead to promising TAM-focused therapeutic strategies for HCC.

Keywords: Hepatocellular carcinoma, Tumor-associated macrophages, Macrophage polarization, Epigenetic modification, Cancer therapy


Article

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Gut and Liver

Published online October 23, 2020

Copyright © Gut and Liver.

Tumor-Associated Macrophages in Hepatocellular Carcinoma: Friend or Foe?

Dexi Zhou1,2,3 , Jiajie Luan1,2,3 , Cheng Huang4 , and Jun Li4

1Department of Pharmacy, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, 2Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution and 3School of Pharmacy, Wannan Medical College, Wuhu, and 4School of Pharmacy, Anhui Medical University, Hefei, China

Correspondence to:Jun Li
School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China
Tel: +86-551-65739915, Fax: +86-551-65739915, E-mail: lijun@ahmu.edu.cn

Received: July 17, 2020; Revised: August 21, 2020; Accepted: August 22, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it has diverse etiologies with multiple mechanisms. The diagnosis of HCC typically occurs at advanced stages when there are limited therapeutic options. Hepatocarcinogenesis is considered a multistep process, and hepatic macrophages play a critical role in the inflammatory process leading to HCC. Emerging evidence has shown that tumor-associated macrophages (TAMs) are crucial components defining the HCC immune microenvironment and represent an appealing option for disrupting the formation and development of HCC. In this review, we summarize the current knowledge of the polarization and function of TAMs in the pathogenesis of HCC, as well as the mechanisms underlying TAM-related anti-HCC therapies. Eventually, novel insights into these important aspects of TAMs and their roles in the HCC microenvironment might lead to promising TAM-focused therapeutic strategies for HCC.

Keywords: Hepatocellular carcinoma, Tumor-associated macrophages, Macrophage polarization, Epigenetic modification, Cancer therapy

Gut and Liver

Vol.15 No.3
May, 2021

pISSN 1976-2283
eISSN 2005-1212

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