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  • 1. Aims and Scope

    Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE

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    Yong Chan Lee Professor of Medicine
    Director, Gastrointestinal Research Laboratory
    Veterans Affairs Medical Center, Univ. California San Francisco
    San Francisco, USA

    Deputy Editor

    Deputy Editor
    Jong Pil Im Seoul National University College of Medicine, Seoul, Korea
    Robert S. Bresalier University of Texas M. D. Anderson Cancer Center, Houston, USA
    Steven H. Itzkowitz Mount Sinai Medical Center, NY, USA
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    All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
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Fasting Blood Glucose Variability and Unfavorable Trajectory Patterns Are Associated with the Risk of Colorectal Cancer

Hyoju Jun1 , Jieun Lee1 , Hye Ah Lee2 , Seong-Eun Kim3 , Ki-Nam Shim3 , Hye-Kyung Jung3 , Sung-Ae Jung3 , and Chang Mo Moon3,4

1Department of Medicine, Ewha Womans University College of Medicine, 2Clinical Trial Center, Ewha Womans University Mokdong Hospital, 3Department of Internal Medicine and 4Inflammation-Cancer Microenvironment Research Center, Ewha Womans University College of Medicine, Seoul, Korea

Correspondence to:Chang Mo Moon
ORCID https://orcid.org/0000-0003-2550-913X
E-mail mooncm27@ewha.ac.kr
Hye Ah Lee
ORCID https://orcid.org/0000-0002-4051-0350
E-mail khyeah@naver.com
Hyoju Jun and Jieun Lee contributed equally to this study as first authors.

Received: February 1, 2021; Revised: May 24, 2021; Accepted: June 29, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gut and Liver

Published online October 1, 2021

Copyright © Gut and Liver.

Abstract

Background/Aims: The relationship between fasting blood glucose (FBG) variability and colorectal cancer (CRC) remains ill-defined. This study aimed to evaluate the association of FBG variability with CRC risk in the healthy population without overt diabetes.
Methods: In the data from the Korean National Health Insurance Service-Health Screening Cohort, we included individuals examined by FBG testing at least 3 times between 2002 and 2007. FBG variability was calculated using standard deviation (SD) and coefficient of variation (CV).
Results: Regarding FBG variability, an increase in the quintile of SD or CV was independently associated with CRC risk (all p for trend <0.01). When the change in FBG was classified into six trajectory patterns, unfavorable trajectory patterns (high stable and upward) were significantly associated with increased CRC risk (hazard ratio [HR] 2.30, p=0.003; HR 1.19, p=0.007, respectively). In subgroup analyses according to the sex, a significant association between FBG variability (SD or CV) and CRC risk was observed in men but not in women. The high stable and upward pattern were also associated with CRC risk in men (HR 2.47, p=0.002; HR 1.21, p=0.012) but not in women.
Conclusions: This study identified that FBG variability and unfavorable trajectory patterns were significantly associated with increased CRC risk in the healthy population without overt diabetes. Our findings suggest that FBG variability as well as FBG itself may be a predictive factor for the development of CRC.

Keywords: Blood glucose, Biological variation, individual, Colorectal neoplasms, Cohort study


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Gut and Liver

Published online October 1, 2021

Copyright © Gut and Liver.

Fasting Blood Glucose Variability and Unfavorable Trajectory Patterns Are Associated with the Risk of Colorectal Cancer

Hyoju Jun1 , Jieun Lee1 , Hye Ah Lee2 , Seong-Eun Kim3 , Ki-Nam Shim3 , Hye-Kyung Jung3 , Sung-Ae Jung3 , and Chang Mo Moon3,4

1Department of Medicine, Ewha Womans University College of Medicine, 2Clinical Trial Center, Ewha Womans University Mokdong Hospital, 3Department of Internal Medicine and 4Inflammation-Cancer Microenvironment Research Center, Ewha Womans University College of Medicine, Seoul, Korea

Correspondence to:Chang Mo Moon
ORCID https://orcid.org/0000-0003-2550-913X
E-mail mooncm27@ewha.ac.kr
Hye Ah Lee
ORCID https://orcid.org/0000-0002-4051-0350
E-mail khyeah@naver.com
Hyoju Jun and Jieun Lee contributed equally to this study as first authors.

Received: February 1, 2021; Revised: May 24, 2021; Accepted: June 29, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/Aims: The relationship between fasting blood glucose (FBG) variability and colorectal cancer (CRC) remains ill-defined. This study aimed to evaluate the association of FBG variability with CRC risk in the healthy population without overt diabetes.
Methods: In the data from the Korean National Health Insurance Service-Health Screening Cohort, we included individuals examined by FBG testing at least 3 times between 2002 and 2007. FBG variability was calculated using standard deviation (SD) and coefficient of variation (CV).
Results: Regarding FBG variability, an increase in the quintile of SD or CV was independently associated with CRC risk (all p for trend <0.01). When the change in FBG was classified into six trajectory patterns, unfavorable trajectory patterns (high stable and upward) were significantly associated with increased CRC risk (hazard ratio [HR] 2.30, p=0.003; HR 1.19, p=0.007, respectively). In subgroup analyses according to the sex, a significant association between FBG variability (SD or CV) and CRC risk was observed in men but not in women. The high stable and upward pattern were also associated with CRC risk in men (HR 2.47, p=0.002; HR 1.21, p=0.012) but not in women.
Conclusions: This study identified that FBG variability and unfavorable trajectory patterns were significantly associated with increased CRC risk in the healthy population without overt diabetes. Our findings suggest that FBG variability as well as FBG itself may be a predictive factor for the development of CRC.

Keywords: Blood glucose, Biological variation, individual, Colorectal neoplasms, Cohort study

Gut and Liver

Vol.15 No.6
November, 2021

pISSN 1976-2283
eISSN 2005-1212

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