Previous Article
PDF
Standard view
Export citation
Share
Vol.16 No.1
January, 2022
Frequency : Quarterly
pISSN 1976-2283
eISSN 2005-1212 
Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE
| Yong Chan Lee |
Professor of Medicine Director, Gastrointestinal Research Laboratory Veterans Affairs Medical Center, Univ. California San Francisco San Francisco, USA |
| Jong Pil Im | Seoul National University College of Medicine, Seoul, Korea |
| Robert S. Bresalier | University of Texas M. D. Anderson Cancer Center, Houston, USA |
| Steven H. Itzkowitz | Mount Sinai Medical Center, NY, USA |
All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.
The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.
Split Viewer
Ji Yong Ahn
Correspondence to:Ji Yong Ahn
Department of Gastroenterology, Asan Digestive Disease Research Institute, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-5667, Fax: +82-2-476-0824, E-mail: ji110@hanmail.net
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Gut Liver 2019; 13(1): 1-2
Published online January 31, 2019 https://doi.org/10.5009/gnl18299
Copyright © Gut and Liver.
Previous studies have shown the association between obesity and gastroesophageal reflux disease (GERD),1–3 and revealed that abdominal visceral fat can affect a lot on aggravating the GERD based on various theoretical backgrounds.2,4,5 In recent studies, abdominal visceral fat volume measured by cross-sectional computed tomography (CT) was a better predictor of erosive esophagitis than body mass index or waist circumference in both men and women.2,6
An increase in abdominal adipose tissue can increase intra-abdominal pressure, increased gastric pressure, lower esophageal sphincter relaxation, formation of hiatal hernia, and subsequent esophageal acid reflux.7 In addition, serum levels of several inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha, which are overexpressed in patients with erosive esophagitis can be elevated by an increase of visceral fat voulume.8 Until now, most of studies have been performed to reveal the aggravating factors of esophagitis, therefore, there are less data about the effect of visceral fat change on the regression of erosive esophagitis. This research9 maybe the first topic which tried to know about the effects between visceral fat change and the regression of esophagitis.
In this issue of
Among total enrolled patients, the regression of erosive esophagitis rate was 49.1% and resulted as a decrease of regression in higher visceral fat group with 3rd and 4th quartile at follow-up. Especially, the highest quartile of visceral fat change reduced the probability of the regression of erosive esophagitis compared to the lowest quartile (relative risk, 0.10; 95% confidential interval, 0.03 to 0.28; p<0.001).
In this study, authors showed that higher visceral fat at follow-up and greater increase of visceral fat during follow-up period reduced the rate of regression in erosive esophagitis patients regardless of baseline visceral fat volume. Based on this research, there are further considerations. First, using this well designed setting, study to know the change of inflammatory cytokines and lipid profiles which have been revealed as associated factors for visceral fat,8,10 according to the change of visceral fat volume, can be considered. This kind of studies can help to solve the problem such as high cost and radiation exposure which should be considered during using CT follow-up. Second, similar with first opinion, newly designed methods for estimating visceral fat volume instead of CT can be thought. If the results of this study are more clearly demonstrated in additional studies, simpler and safer methods to know the change of visceral fat volume will be need in patients with esophagitis. Third, treatment plan and follow-up methods in patients with erosive esophagitis can be modified that clinicians can emphasize more about weight control and life style change.
This study, which was performed on the foundation of their good previous researches, has important clinical meaning because authors found that the visceral fat change during follow-up period can affect the regression of erosive esophagitis. Based on these results, further studies to clearly demonstrate the action mechanism are expected to clinically help reducing esophagitis.
No potential conflict of interest relevant to this article was reported.
Gut and Liver 2019; 13(1): 1-2
Published online January 31, 2019 https://doi.org/10.5009/gnl18299
Copyright © Gut and Liver.
Ji Yong Ahn
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to:Ji Yong Ahn
Department of Gastroenterology, Asan Digestive Disease Research Institute, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-5667, Fax: +82-2-476-0824, E-mail: ji110@hanmail.net
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Previous studies have shown the association between obesity and gastroesophageal reflux disease (GERD),1–3 and revealed that abdominal visceral fat can affect a lot on aggravating the GERD based on various theoretical backgrounds.2,4,5 In recent studies, abdominal visceral fat volume measured by cross-sectional computed tomography (CT) was a better predictor of erosive esophagitis than body mass index or waist circumference in both men and women.2,6
An increase in abdominal adipose tissue can increase intra-abdominal pressure, increased gastric pressure, lower esophageal sphincter relaxation, formation of hiatal hernia, and subsequent esophageal acid reflux.7 In addition, serum levels of several inflammatory cytokines such as interleukin-6 and tumor necrosis factor-alpha, which are overexpressed in patients with erosive esophagitis can be elevated by an increase of visceral fat voulume.8 Until now, most of studies have been performed to reveal the aggravating factors of esophagitis, therefore, there are less data about the effect of visceral fat change on the regression of erosive esophagitis. This research9 maybe the first topic which tried to know about the effects between visceral fat change and the regression of esophagitis.
In this issue of
Among total enrolled patients, the regression of erosive esophagitis rate was 49.1% and resulted as a decrease of regression in higher visceral fat group with 3rd and 4th quartile at follow-up. Especially, the highest quartile of visceral fat change reduced the probability of the regression of erosive esophagitis compared to the lowest quartile (relative risk, 0.10; 95% confidential interval, 0.03 to 0.28; p<0.001).
In this study, authors showed that higher visceral fat at follow-up and greater increase of visceral fat during follow-up period reduced the rate of regression in erosive esophagitis patients regardless of baseline visceral fat volume. Based on this research, there are further considerations. First, using this well designed setting, study to know the change of inflammatory cytokines and lipid profiles which have been revealed as associated factors for visceral fat,8,10 according to the change of visceral fat volume, can be considered. This kind of studies can help to solve the problem such as high cost and radiation exposure which should be considered during using CT follow-up. Second, similar with first opinion, newly designed methods for estimating visceral fat volume instead of CT can be thought. If the results of this study are more clearly demonstrated in additional studies, simpler and safer methods to know the change of visceral fat volume will be need in patients with esophagitis. Third, treatment plan and follow-up methods in patients with erosive esophagitis can be modified that clinicians can emphasize more about weight control and life style change.
This study, which was performed on the foundation of their good previous researches, has important clinical meaning because authors found that the visceral fat change during follow-up period can affect the regression of erosive esophagitis. Based on these results, further studies to clearly demonstrate the action mechanism are expected to clinically help reducing esophagitis.
No potential conflict of interest relevant to this article was reported.
pISSN 1976-2283
eISSN 2005-1212
Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut atnd Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. +MORE
| Yong Chan Lee |
Professor of Medicine Director, Gastrointestinal Research Laboratory Veterans Affairs Medical Center, Univ. California San Francisco San Francisco, USA |
| Jong Pil Im | Seoul National University College of Medicine, Seoul, Korea |
| Robert S. Bresalier | University of Texas M. D. Anderson Cancer Center, Houston, USA |
| Steven H. Itzkowitz | Mount Sinai Medical Center, NY, USA |
All papers submitted to Gut and Liver are reviewed by the editorial team before being sent out for an external peer review to rule out papers that have low priority, insufficient originality, scientific flaws, or the absence of a message of importance to the readers of the Journal. A decision about these papers will usually be made within two or three weeks.
The remaining articles are usually sent to two reviewers. It would be very helpful if you could suggest a selection of reviewers and include their contact details. We may not always use the reviewers you recommend, but suggesting reviewers will make our reviewer database much richer; in the end, everyone will benefit. We reserve the right to return manuscripts in which no reviewers are suggested.
The final responsibility for the decision to accept or reject lies with the editors. In many cases, papers may be rejected despite favorable reviews because of editorial policy or a lack of space. The editor retains the right to determine publication priorities, the style of the paper, and to request, if necessary, that the material submitted be shortened for publication.
