GNL Gut and Liver
  1. Shuni Duan, Xiaojiaoyang Li, Guifang Fan, Runping Liu. Targeting bile acid signaling for the treatment of liver diseases: From bench to bed. Biomedicine & Pharmacotherapy 2022;152:113154
    https://doi.org/10.1016/j.biopha.2022.113154
  2. Tadashi Ariyoshi, Mao Hagihara, Motomichi Takahashi, Hiroshige Mikamo. Effect of Clostridium butyricum on Gastrointestinal Infections. Biomedicines 2022;10:483
    https://doi.org/10.3390/biomedicines10020483
  3. Arjuna Singanayagam, Evangelos Triantafyllou. Macrophages in Chronic Liver Failure: Diversity, Plasticity and Therapeutic Targeting. Front. Immunol. 2021;12
    https://doi.org/10.3389/fimmu.2021.661182
  4. Xiang Zeng, Zhijun Zeng, Qihua Wang, Wanting Liang, Yufeng Guo, Xia Huo. Alterations of the gut microbiota and metabolomics in children with e-waste lead exposure. Journal of Hazardous Materials 2022;434:128842
    https://doi.org/10.1016/j.jhazmat.2022.128842
  5. Shiyan Yang, Yajun Cheng, Xiaolong Wang, Suyang Yue, Xi Wang, Li Tang, Hailun Li, Jie Zhang, Qingping Xiong, Shanzhong Tan. Chinese herbal decoction, Yi-Qi-Jian-Pi formula exerts anti-hepatic fibrosis effects in mouse models of CCl4-induced liver fibrosis. Heliyon 2024;10:e26129
    https://doi.org/10.1016/j.heliyon.2024.e26129
  6. Xing Yang, Langhuan Lei, Wei Shi, Xiaozhen Li, Xiaozhi Huang, Liuyan Lan, Jiali Lin, Qiuyu Liang, Wei Li, Jianrong Yang. Probiotics are beneficial for liver cirrhosis: a systematic review and meta-analysis of randomized control trials. Front. Med. 2024;11
    https://doi.org/10.3389/fmed.2024.1379333
  7. Yu Zhang, Haitian Fang, Tong Wang, Zhigang Zhang, Tianxiang Zhu, Lei Xiong, Haiming Hu, Hongtao Liu. Lactobacillus acidophilus‐Fermented Jujube Juice Ameliorates Chronic Liver Injury in Mice via Inhibiting Apoptosis and Improving the Intestinal Microecology. Molecular Nutrition Food Res 2024;68
    https://doi.org/10.1002/mnfr.202300334
  8. Bingbing Zhao, Ye Jin, Meixin Shi, Ligen Yu, Guopeng Li, Wenjie Cai, Zhaoyang Lu, Can Wei. Gut microbial dysbiosis is associated with metabolism and immune factors in liver fibrosis mice. International Journal of Biological Macromolecules 2024;258:129052
    https://doi.org/10.1016/j.ijbiomac.2023.129052
  9. Zhi-Hua Liu, Shu Ai, Yanzhou Xia, Hui-Li Wang. Intestinal toxicity of Pb: Structural and functional damages, effects on distal organs and preventive strategies. Science of The Total Environment 2024;931:172781
    https://doi.org/10.1016/j.scitotenv.2024.172781
  10. Satoshi SATO, Chikara IINO, Daisuke CHINDA, Takafumi SASADA, Go SOMA, Tetsuyuki TATEDA, Keisuke FURUSAWA, Kenta YOSHIDA, Kaori SAWADA, Tatsuya MIKAMI, Shigeyuki NAKAJI, Hirotake SAKURABA, Shinsaku FUKUDA. Gut microbiota involvement in the effect of water-soluble dietary fiber on fatty liver and fibrosis. 2025;44:49
    https://doi.org/10.12938/bmfh.2024-046
  11. Chen-yu Zhang, Jing Zhao, Ming-xian Mao, Zhan-qin Zhao, Feng-jun Liu, Hong-wei Wang. Disordered Expression of Tight Junction Proteins Is Involved in the Mo-induced Intestinal Microenvironment Dysbiosis in Sheep. Biol Trace Elem Res 2023;201:204
    https://doi.org/10.1007/s12011-022-03155-0
  12. Satoshi Sato, Chikara Iino, Takafumi Sasada, Go Soma, Keisuke Furusawa, Kenta Yoshida, Kaori Sawada, Tatsuya Mikami, Shigeyuki Nakaji, Hirotake Sakuraba, Shinsaku Fukuda. Epidemiological Study on the Interaction between the PNPLA3 (rs738409) and Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease. Genes 2024;15:1172
    https://doi.org/10.3390/genes15091172
  13. Shi‐Qing Li, Ya‐Ru Wang, Zhong‐Liang Xie, Yan Wang, Zi‐Han Feng, Jian‐Hao Xu, Bing Yuan, Yi‐Tong Zhang, Guan Yang, Jing‐Lin Wang, Yuan Yuan. NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice. Clinical & Translational Med 2024;14
    https://doi.org/10.1002/ctm2.70099
  14. I. V. Nikalayeva, V. M. Sheibak, E. M. Doroshenko. Amino acid balance of microbial-tissue complex in the small intestinal and liver under administration of lead acetate. Vescì Akademìì navuk Belarusì. Seryâ biâlagičnyh navuk 2022;67:197
    https://doi.org/10.29235/1029-8940-2022-67-2-197-205
  15. Satoshi Sato, Chikara Iino, Daisuke Chinda, Takafumi Sasada, Tetsuyuki Tateda, Masatoshi Kaizuka, Hiroki Nomiya, Go Igarashi, Kaori Sawada, Tatsuya Mikami, Shigeyuki Nakaji, Hirotake Sakuraba, Shinsaku Fukuda. Effect of Liver Fibrosis on Oral and Gut Microbiota in the Japanese General Population Determined by Evaluating the FibroScan–Aspartate Aminotransferase Score. IJMS 2023;24:13470
    https://doi.org/10.3390/ijms241713470
  16. Devi Basumatary, Santanu Das, M. Bidyarani Devi, G. Shalini Devi, Pranamika Sarma, Ashis K. Mukherjee, Mojibur R. Khan, Jagat C. Borah. Garcinol enriched fraction of Garcinia morella (Gaertn.) Desr. fruit rind improves gut health and reduces the risk of nonalcoholic fatty liver disease by regulating PCK1/ACC/SREBP1/FASn pathway in a mouse model. Food Research International 2024;197:115285
    https://doi.org/10.1016/j.foodres.2024.115285
  17. Zhaoyao Qi, Xinxin Qi, Yuanhui Xu, Hongguang Sun, Dengfeng Li, Jincun Liu, Meili Cong, Tao Liu, Vladimir Jurisic. Alterations in the “Gut–Liver Axis” on Rats with Immunological Hepatic Fibrosis. Journal of Immunology Research 2023;2023:1
    https://doi.org/10.1155/2023/5577850
  18. Soon Jae Kwon, Yun Seok Kim, Jihoon Tak, Sang Gil Lee, Eun Byul Lee, Sang Geon Kim. Hepatic Gα13 ablation shifts region-specific colonic inflammatory status by modulating the bile acid synthetic pathway in mice. Sci Rep 2024;14
    https://doi.org/10.1038/s41598-024-70254-4
  19. Hammad Zafar, Brenda Jimenez, Alison Schneider. Small intestinal bacterial overgrowth: current update. 2023;39:522
    https://doi.org/10.1097/MOG.0000000000000971
  20. Rong Yang, Li Qian. Research on Gut Microbiota-Derived Secondary Bile Acids in Cancer Progression. Integr Cancer Ther 2022;21
    https://doi.org/10.1177/15347354221114100
  21. Yuqin Cheng, Shuaishuai Wang, Wenfei Zhu, Zijing Xu, Ling Xiao, Jianping Wu, Yufen Meng, Junfeng Zhang, Chun Cheng. Deoxycholic acid inducing chronic atrophic gastritis with colonic mucosal lesion correlated to mucosal immune dysfunction in rats. Sci Rep 2024;14
    https://doi.org/10.1038/s41598-024-66660-3
  22. Ivan Rankovic, Ivana Babic, Jelena Martinov Nestorov, Jelena Bogdanovic, Maja Stojanovic, Jovanka Trifunovic, Nikola Panic, Mihailo Bezmarevic, Jelena Jevtovic, Dusan Micic, Vladimir Dedovic, Nemanja Djuricic, Filip Pilipovic, Elena Curakova Ristovska, Tijana Glisic, Sanja Kostic, Nemanja Stojkovic, Nata Joksimovic, Mileva Bascarevic, Aleksandra Bozovic, Lewis Elvin, Ajibola Onifade, Keith Siau, Elizaveta Koriakovskaia, Vladimir Milivojevic. Joint Group and Multi Institutional Position Opinion: Cirrhotic Cardiomyopathy—From Fundamentals to Applied Tactics. Medicina 2024;61:46
    https://doi.org/10.3390/medicina61010046
  23. Karli R. LeFort, Wiramon Rungratanawanich, Byoung-Joon Song. Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction. Cell. Mol. Life Sci. 2024;81
    https://doi.org/10.1007/s00018-023-05061-7
  24. Satoshi MURAKAMI, Takashi ASAHARA. Recent Studies on the Onset Factors of Bacterial Translocation in Livestock. J.Jpn.Vet.Med.Assoc. 2022;75:e91
    https://doi.org/10.12935/jvma.75.e91
  25. Jixuan Wang, Zhiwen Sun, Jingri Xie, Wanli Ji, Yang Cui, Zongxiong Ai, Guoying Liang. Inflammasome and pyroptosis in autoimmune liver diseases. Front. Immunol. 2023;14
    https://doi.org/10.3389/fimmu.2023.1150879
  26. Reham Hassan, Maiju Myllys, Lisa Brackhagen, Zaynab Hobloss, Daniela González, Abdel-latif Seddek, Adrian Friebel, Stefan Hoehme, Rosemarie Marchan, Michael Trauner, Jan G. Hengstler, Ahmed Ghallab. Colchicine overdose impairs the capacity of Kupffer cells to clear foreign particles and endotoxins. Arch Toxicol 2022;96:3067
    https://doi.org/10.1007/s00204-022-03353-8
  27. Zi-Ying Wang, Ping-Ping Gao, Ling Li, Ting-Ting Chen, Nan Li, Meng Qi, Sheng-Nan Zhang, Ya-Ping Xu, Yu-Han Wang, Shi-Hao Zhang, Ling-Ling Zhang, Wei Wei, Min Du, Wu-Yi Sun. Dextran sulfate sodium-induced gut microbiota dysbiosis aggravates liver injury in mice with S100-induced autoimmune hepatitis. Immunology Letters 2023;263:70
    https://doi.org/10.1016/j.imlet.2023.10.001
  28. Razvan Igna, Irina Gîrleanu, Camelia Cojocariu, Laura Huiban, Cristina Muzîca, Ana-Maria Sîngeap, Cătălin Sfarti, Stefan Chiriac, Oana Cristina Petrea, Sebastian Zenovia, Robert Nastasa, Tudor Cuciureanu, Remus Stafie, Ermina Stratina, Adrian Rotaru, Carol Stanciu, Mihaela Blaj, Anca Trifan. The Role of Presepsin and Procalcitonin in Early Diagnosis of Bacterial Infections in Cirrhotic Patients with Acute-on-Chronic Liver Failure. JCM 2022;11:5410
    https://doi.org/10.3390/jcm11185410
  29. Aanchal Bharti, Isar Sharma, Ritu Mahajan, Seema Langer, Nisha Kapoor. From Cirrhosis to the Dysbiosis (A Loop of Cure or Complications?). Indian J Microbiol 2024;64:810
    https://doi.org/10.1007/s12088-024-01267-w
  30. Maren L. Smith, James B. Wade, Jennifer Wolstenholme, Jasmohan S. Bajaj. Gut microbiome-brain-cirrhosis axis. 2024;80:465
    https://doi.org/10.1097/HEP.0000000000000344
  31. Kazuhiko Ikeuchi, Takeya Tsutsumi, Aya Ishizaka, Taketoshi Mizutani, Ayako Sedohara, Michiko Koga, Satoru Tamaoki, Hiroshi Yotsuyanagi. Modulation of duodenal and jejunal microbiota by rifaximin in mice with CCl4-induced liver fibrosis. Gut Pathog 2023;15
    https://doi.org/10.1186/s13099-023-00541-4
  32. Lingjun Tong, Sitong Zhang, Qiqi Liu, Chenyuan Huang, Haining Hao, Michelle Siying Tan, Xiaodong Yu, Charles Kang Liang Lou, Rong Huang, Zhe Zhang, Tongjie Liu, Pimin Gong, Cheng Han Ng, Mark Muthiah, Giorgia Pastorin, Matthias Gerhard Wacker, Xiaoyuan Chen, Gert Storm, Cheun Neng Lee, Lanwei Zhang, Huaxi Yi, Jiong-Wei Wang. Milk-derived extracellular vesicles protect intestinal barrier integrity in the gut-liver axis. Sci. Adv. 2023;9
    https://doi.org/10.1126/sciadv.ade5041
  33. Benedict J. Maliakkal, Jiten P. Kothadia. Hepatology. 2023.
    https://doi.org/10.1016/B978-0-443-26710-9.00007-9
  34. Qinyan Yao, Zihan Yu, Qingguo Meng, Jihua Chen, Yaxin Liu, Wenxuan Song, Xiangfeng Ren, Jinjie Zhou, Xin Chen. The role of small intestinal bacterial overgrowth in obesity and its related diseases. Biochemical Pharmacology 2023;212:115546
    https://doi.org/10.1016/j.bcp.2023.115546
  35. Tongmin Huang, Xingfen Zhang, Kun Yan, Dandi Lou, Yujing He, Senjie Dai, Dingcheng Zheng, Ping Chen, Feng Wu, Lihu Gu. Transjugular intrahepatic portosystemic shunt for pyrrolidine alkaloids-induced hepatic sinusoidal obstruction syndrome: a retrospective cohort study. 2023;35:1004
    https://doi.org/10.1097/MEG.0000000000002591
  36. Nimish Godbole, Antti Kyrönlahti, Maria Hukkinen, Marjut Pihlajoki, Markku Heikinheimo, Mikko P. Pakarinen. Bacterial translocation markers and toll‐like receptors in biliary atresia following successful portoenterostomy. Acta Paediatrica 2023;112:2210
    https://doi.org/10.1111/apa.16893
  37. Qinglan Xia, Yumeng Lei, Jiadun Wang, Qiang Wang. Probiotic management and inflammatory factors as a novel treatment in cirrhosis: A systematic review and meta-analysis. 2023;18
    https://doi.org/10.1515/biol-2022-0741
  38. Sitong Zhang, Qiyue Wang, Daniel En Liang Tan, Vritika Sikka, Cheng Han Ng, Yan Xian, Dan Li, Mark Muthiah, Nicholas W. S. Chew, Gert Storm, Lingjun Tong, Jiong‐Wei Wang. Gut‐liver axis: Potential mechanisms of action of food‐derived extracellular vesicles. J of Extracellular Vesicle 2024;13
    https://doi.org/10.1002/jev2.12466
  39. Do Seon Song, Jin Mo Yang, Young Kul Jung, Hyung Joon Yim, Hee Yeon Kim, Chang Wook Kim, Soon Sun Kim, Jae Youn Cheong, Hae Lim Lee, Sung Won Lee, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim. Rifaximin treatment in patients with severe alcoholic hepatitis: A multicenter, randomized controlled, open-label, pilot trial. Annals of Hepatology 2024:101749
    https://doi.org/10.1016/j.aohep.2024.101749
  40. Chengcong Liu, Guoxin Sun, Huizhe Wang, Gaishuang Shang, Xiong Yan, Xiao Zou. Analysis of the intestinal flora in patients with primary liver cancer*. 2023;9:28
    https://doi.org/10.1007/s10330-022-0575-5
  41. Pinky Juneja, Syed Nazrin Ruhina Rahman, Deepika Jakhar, Akash Kumar Mourya, Dinesh M. Tripathi, Impreet Kaur, Vaibhav Tiwari, Sumati Rohilla, Abhishek Gupta, Preety Rawal, Sukriti Baweja, Archana Rastogi, V.G.M. Naidu, Shiv K. Sarin, Subham Banerjee, Savneet Kaur. Recombinant VEGF-C (Cys156Ser) improves mesenteric lymphatic drainage and gut immune surveillance in experimental cirrhosis. JHEP Reports 2023;5:100816
    https://doi.org/10.1016/j.jhepr.2023.100816
  42. Xin Liu, Xingsi Qi, Rongshuang Han, Tao Mao, Zibin Tian. Gut microbiota causally affects cholelithiasis: a two-sample Mendelian randomization study. Front. Cell. Infect. Microbiol. 2023;13
    https://doi.org/10.3389/fcimb.2023.1253447
  43. 霞 万. Research Progress of Intestinal Complications in End-Stage Liver Disease. ACM 2024;14:428
    https://doi.org/10.12677/ACM.2024.141061
  44. Ali Shahbazi, Ali Sepehrinezhad, Edris Vahdani, Raika Jamali, Monireh Ghasempour, Shirin Massoudian, Sajad Sahab Negah, Fin Stolze Larsen. Gut Dysbiosis and Blood-Brain Barrier Alteration in Hepatic Encephalopathy: From Gut to Brain. Biomedicines 2023;11:1272
    https://doi.org/10.3390/biomedicines11051272
  45. Razvan Igna, Irina Gîrleanu, Camelia Cojocariu, Cristina Muzîca, Laura Huiban, Catalin Sfarti, Tudor Cuciureanu, Stefan Chiriac, Ana-Maria Sîngeap, Oana Cristina Petrea, Remus Stafie, Sebastian Zenovia, Robert Năstasă, Ermina Stratina, Adrian Rotaru, Carol Stanciu, Anca Trifan, Mihaela Blaj. The Role of Presepsin in Diagnosing Infections in Patients with Liver Cirrhosis and Overt Hepatic Encephalopathy. Diagnostics 2022;12:2077
    https://doi.org/10.3390/diagnostics12092077
  46. Punnag Saha, Peter T. Skidmore, LaRinda A. Holland, Ayan Mondal, Dipro Bose, Ratanesh K. Seth, Kimberly Sullivan, Patricia A. Janulewicz, Ronnie Horner, Nancy Klimas, Mitzi Nagarkatti, Prakash Nagarkatti, Efrem S. Lim, Saurabh Chatterjee. Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk. Brain Sciences 2021;11:905
    https://doi.org/10.3390/brainsci11070905
  47. Lin Cheng, Jianyou Shi, Haoyuan Peng, Rongsheng Tong, Yonghe Hu, Dongke Yu. Probiotics and liver fibrosis: An evidence-based review of the latest research. Journal of Functional Foods 2023;109:105773
    https://doi.org/10.1016/j.jff.2023.105773
  48. Naveen Jeyaraman, Madhan Jeyaraman, Tejaswin Mariappan, Sathish Muthu, Swaminathan Ramasubramanian, Shilpa Sharma, Gabriel Silva Santos, Lucas Furtado da Fonseca, José Fábio Lana. Insights of gut-liver axis in hepatic diseases: Mechanisms, clinical implications, and therapeutic potentials. World J Gastrointest Pharmacol Ther 2024;15
    https://doi.org/10.4292/wjgpt.v15.i6.98146
  49. Kohei Kotani, Norifumi Kawada. Recent Advances in the Pathogenesis and Clinical Evaluation of Portal Hypertension in Chronic Liver Disease. Gut and Liver 2024;18:27
    https://doi.org/10.5009/gnl230072
  50. Maria E. Tecos, Allie E. Steinberger, Jun Guo, Deborah C. Rubin, Nicholas O. Davidson, Brad W. Warner. Roles for Bile Acid Signaling and Nonsense-Mediated Ribonucleic Acid Decay in Small Bowel Resection-Associated Liver Injury. Journal of Surgical Research 2024;293:433
    https://doi.org/10.1016/j.jss.2023.09.046
  51. Irina Efremova, Roman Maslennikov, Oleg Medvedev, Anna Kudryavtseva, Anastasia Avdeeva, George Krasnov, Filipp Romanikhin, Mikhail Diatroptov, Maria Fedorova, Elena Poluektova, Anna Levshina, Vladimir Ivashkin. Gut Microbiota and Biomarkers of Intestinal Barrier Damage in Cirrhosis. Microorganisms 2024;12:463
    https://doi.org/10.3390/microorganisms12030463
  52. Han Ah Lee, Young Chang, Pil Soo Sung, Eileen L. Yoon, Hye Won Lee, Jeong-Ju Yoo, Young-Sun Lee, Jihyun An, Do Seon Song, Young Youn Cho, Seung Up Kim, Yoon Jun Kim. Therapeutic mechanisms and beneficial effects of non-antidiabetic drugs in chronic liver diseases. Clin Mol Hepatol 2022;28:425
    https://doi.org/10.3350/cmh.2022.0186
  53. Yiran Liang, Donghui Liu, Yan Li, Haonan Hou, Pengxi Li, Xiaoran Ma, Peize Li, Jing Zhan, Peng Wang. Maternal polysorbate 80 intake promotes offspring metabolic syndrome through vertical microbial transmission in mice. Science of The Total Environment 2024;909:168624
    https://doi.org/10.1016/j.scitotenv.2023.168624
  54. S. N. Mekhtiyev, O. A. Mekhtiyeva, O. M. Berko, A. M. Kolodkin. Role of increased intestinal permeability in the development and progression of liver diseases. ECG 2023:130
    https://doi.org/10.31146/1682-8658-ecg-220-12-130-139
  55. Long Huang, Qingsheng Yu, Hui Peng, Zhou Zhen. Alterations of gut microbiome and effects of probiotic therapy in patients with liver cirrhosis: A systematic review and meta-analysis. 2022;101:e32335
    https://doi.org/10.1097/MD.0000000000032335
  56. Francesco Violi, Vittoria Cammisotto, Simona Bartimoccia, Pasquale Pignatelli, Roberto Carnevale, Cristina Nocella. Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease. Nat Rev Cardiol 2023;20:24
    https://doi.org/10.1038/s41569-022-00737-2
  57. Hao Huang, Fang Fang, Zheng Jia, Wen Peng, Yi Wu, Tao Huang. Influences of Oral Administration of Probiotics on Posthepatectomy Recovery in Patients in Child-Pugh Grade. Computational and Mathematical Methods in Medicine 2022;2022:1
    https://doi.org/10.1155/2022/2942982
  58. Maria E. Tecos, Allie E. Steinberger, Jun Guo, Deborah C. Rubin, Nicholas O. Davidson, Brad W. Warner. Disruption of Enterohepatic Circulation of Bile Acids Ameliorates Small Bowel Resection Associated Hepatic Injury. Journal of Pediatric Surgery 2023;58:1074
    https://doi.org/10.1016/j.jpedsurg.2023.02.031
  59. Hala Mansoor, Mahnam Khizer, Aneela Afreen, Noor Masood Sadiq, Aamir Habib, Shafqat Ali, Asim Raza, Tayyaba Hafeez. Systolic and diastolic impairment in cirrhotic cardiomyopathy: insights from a cross-sectional study. Egypt Liver Journal 2024;14
    https://doi.org/10.1186/s43066-024-00367-y
  60. Nicolás Ortiz-López, Ana María Madrid, Larissa Aleman, Alejandra Zazueta, Gladys Smok, Lucía Valenzuela-Pérez, Jaime Poniachik, Caroll J. Beltrán. Small intestinal bacterial overgrowth in obese patients with biopsy-confirmed metabolic dysfunction-associated steatotic liver disease: a cross-sectional study. Front. Med. 2024;11
    https://doi.org/10.3389/fmed.2024.1376148
  61. Irina Efremova, Roman Maslennikov, Aliya Alieva, Elena Poluektova, Vladimir Ivashkin. Small Intestinal Bacterial Overgrowth Is Associated with Poor Prognosis in Cirrhosis. Microorganisms 2023;11:1017
    https://doi.org/10.3390/microorganisms11041017
  62. Jing Liu, Dakai Yang, Xiaojing Wang, Paul Tetteh Asare, Qingwen Zhang, Lixin Na, Lei Shao. Gut Microbiota Targeted Approach in the Management of Chronic Liver Diseases. Front. Cell. Infect. Microbiol. 2022;12
    https://doi.org/10.3389/fcimb.2022.774335
  63. Lei Dou, Yang Peng, Bin Zhang, Huiyuan Yang, Kai Zheng. Immune Remodeling during Aging and the Clinical Significance of Immunonutrition in Healthy Aging. Aging and disease 2023
    https://doi.org/10.14336/AD.2023.0923
  64. You Sun Kim, Edward H. Hurley, Yoojeong Park, Sungjin Ko. Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis. Exp Mol Med 2023;55:1380
    https://doi.org/10.1038/s12276-023-01042-9
  65. Yihao He, Ru Guo, Lu Yang, Ling Li, Tong Zhang, Bing Wang, Yongzhuo Huang. Phospholipid complex-based microemulsion for treating concurrence of primary sclerosing cholangitis and inflammatory bowel disease via gut-liver crosstalk. Chinese Chemical Letters 2024:110778
    https://doi.org/10.1016/j.cclet.2024.110778
  66. Jung A Eom, Goo Hyun Kwon, Na Yeon Kim, Eun Ju Park, Sung Min Won, Jin Ju Jeong, Ganesan Raja, Haripriya Gupta, Yoseph Asmelash Gebru, Satyapriya Sharma, Ye Rin Choi, Hyeong Seop Kim, Sang Jun Yoon, Ji Ye Hyun, Min Kyo Jeong, Hee Jin Park, Byeong Hyun Min, Mi Ran Choi, Dong Joon Kim, Ki Tae Suk. Diet-Regulating Microbiota and Host Immune System in Liver Disease. IJMS 2021;22:6326
    https://doi.org/10.3390/ijms22126326
  67. Lianhua Kong, Juncong Ma, Li Dong, Chuanlong Zhu, Jie Zhang, Jun Li. Metformin exerts anti-liver fibrosis effect based on the regulation of gut microbiota homeostasis and multi-target synergy. Heliyon 2024;10:e24610
    https://doi.org/10.1016/j.heliyon.2024.e24610
  68. Josip Stojic, Michał Kukla, Ivica Grgurevic. The Intestinal Microbiota in the Development of Chronic Liver Disease: Current Status. Diagnostics 2023;13:2960
    https://doi.org/10.3390/diagnostics13182960
  69. Faeze Ahmadi Beni, Hossein Saffarfar, Anis Elhami, Mohammad Kazemi, Sheik Ahmed. Gut Microbiota Dysbiosis: A Neglected Risk Factor for Male and Female Fertility. Cellular Microbiology 2024;2024
    https://doi.org/10.1155/cmi/7808354
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