GNL Gut and Liver
  1. U. Maggi, M. Iavarone, M. Fabbi, D. Yiu, G. Fornoni, E. Melada, D. Dondossola, P. Cantù, G. Rossi. Liver Transplantations and Brain Dead Donors With Alcohol Abuse. Transplantation Proceedings 2018;50:3105
    https://doi.org/10.1016/j.transproceed.2018.08.023
  2. Laura Buttler, Anja Tiede, Marie Griemsmann, Hannah Rieland, Jim Mauz, Julia Kahlhöfer, Heiner Wedemeyer, Markus Cornberg, Tammo L. Tergast, Benjamin Maasoumy, Katharina L. Hupa-Breier. Folic acid supplementation is associated with a decreased mortality and reduced hospital readmission in patients with decompensated alcohol-related liver cirrhosis. Clinical Nutrition 2024;43:1719
    https://doi.org/10.1016/j.clnu.2024.05.044
  3. Ao Ren, Wenjing He, Jiawei Rao, Dongmei Ye, Pengrui Cheng, Qian Jian, Zongli Fu, Xuzhi Zhang, Ronghai Deng, Yifang Gao, Yi Ma. Dysregulation of innate cell types in the hepatic immune microenvironment of alcoholic liver cirrhosis. Front. Immunol. 2023;14
    https://doi.org/10.3389/fimmu.2023.1034356
  4. Jeung Hui Pyo, Tae Jun Kim, Hyuk Lee, Sung Chul Choi, Soo‐Jin Cho, Yoon‐Ho Choi, Yang Won Min, Byung‐Hoon Min, Jun Haeng Lee, Minwoong Kang, Yeong Chan Lee, Jae J Kim. Proton pump inhibitors use and the risk of fatty liver disease: A nationwide cohort study. J of Gastro and Hepatol 2021;36:1235
    https://doi.org/10.1111/jgh.15236
  5. Hao Chen, Xiaofeng Li, Yingyin Sun, Yan Du, Sha Wu, Yuanyuan Wu, Huiping Liu, Yaru Liu, Yongmei Wang, Qihang Zhao, Shi Yin. HAO1 negatively regulates liver macrophage activation via the NF-κB pathway in alcohol-associated liver disease. Cellular Signalling 2022;99:110436
    https://doi.org/10.1016/j.cellsig.2022.110436
  6. Chenxuan Wu, Jun Liu, Yanbin Tang, Yanxiao Li, Qiaojuan Yan, Zhengqiang Jiang. Hepatoprotective Potential of Partially Hydrolyzed Guar Gum against Acute Alcohol-Induced Liver Injury in Vitro and Vivo. Nutrients 2019;11:963
    https://doi.org/10.3390/nu11050963
  7. Sevda Zarei, Farzan Ghalichi, Majid Ahmadlouydarab. Computational exploration of injection strategies for improving medicine distribution in the liver. Computers in Biology and Medicine 2025;185:109585
    https://doi.org/10.1016/j.compbiomed.2024.109585
  8. Beata Kasztelan-Szczerbinska, Katarzyna Adamczyk, Agata Surdacka, Jacek Rolinski, Agata Michalak, Agnieszka Bojarska-Junak, Mariusz Szczerbinski, Halina Cichoz-Lach. Gender-related disparities in the frequencies of PD-1 and PD-L1 positive peripheral blood T and B lymphocytes in patients with alcohol-related liver disease: a single center pilot study. 2021;9:e10518
    https://doi.org/10.7717/peerj.10518
  9. Xingtao Zhao, Xinyan Xue, Cheng Wang, Jing Wang, Cheng Peng, Yunxia Li. Emerging roles of Sirtuins in alleviating alcoholic liver Disease: A comprehensive review. International Immunopharmacology 2022;108:108712
    https://doi.org/10.1016/j.intimp.2022.108712
  10. Jiayue Liu, Lingzhou Kong, Mengting Shao, Changhai Sun, Changxu Li, Yanyan Wang, Xue Chai, Yuliang Wang, Yu Zhang, Xiaoliang Li, Hong Zhao. Seabuckthorn polysaccharide combined with astragalus polysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora. Front. Endocrinol. 2022;13
    https://doi.org/10.3389/fendo.2022.1018557
  11. Betina de Melo Ilkiu, Luiza Silva de Castro, Claudia Alexandra Pontes Ivantes, Alcindo Pissaia Junior, Thelma Larocca Skare, Renato Nisihara. Hospital admissions for chronic liver diseases: a temporal study in the South Region of Brazil. Rev. Assoc. Med. Bras. 2024;70
    https://doi.org/10.1590/1806-9282.20231430
  12. Takahito Takase, Tsudoi Toyoda, Naoyuki Kobayashi, Takashi Inoue, Tomoko Ishijima, Keiko Abe, Hiroshi Kinoshita, Youichi Tsuchiya, Shinji Okada, Partha Mukhopadhyay. Dietary iso-α-acids prevent acetaldehyde-induced liver injury through Nrf2-mediated gene expression. PLoS ONE 2021;16:e0246327
    https://doi.org/10.1371/journal.pone.0246327
  13. Aaron B. Koenig, Albert Tan, Hala Abdelaal, Fanny Monge, Zobair M. Younossi, Zachary D. Goodman. Review article: Hepatic steatosis and its associations with acute and chronic liver diseases. Aliment Pharmacol Ther 2024;60:167
    https://doi.org/10.1111/apt.18059
  14. Viola Schlossberger, Mathias Worni, Christina Kihm, Matteo Montani, Christian Datz, Jochen Hampe, Felix Stickel. Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis. Gut and Liver 2019;13:77
    https://doi.org/10.5009/gnl18037
  15. Kizito Eneye Bello, Ahmad Adebayo Irekeola, Sameer Badri Al-Mhanna, Okolo Martin-Luther Oseni, Adejo Patience Omebije, Rafidah Hanim Shueb, Nazri Mustaffa. Prevalence of Spontaneous Bacterial Peritonitis (SBP) in Hepatitis B (HBV), and Hepatitis C (HCV) Liver Cirrhosis: A Systematic Review and Meta-Analysis. Healthcare 2023;11:275
    https://doi.org/10.3390/healthcare11020275
  16. L. B. Lazebnik, E. V. Golovanova, L. V. Tarasova, A. B. Krivosheev, E. I. Sas, E. Yu. Eremina, D. I. Trukhan, O. V. Hlynova, Yu. V. Tsyganova. Adult Alcoholic Liver Disease. jour 2020;174:4
    https://doi.org/10.31146/1682-8658-ecg-174-2-4-28
  17. Xiaoxia Jiang, Yafeng Zhou, Yun Zhang, Diying Tian, Su Jiang, Yunping Tang. Hepatoprotective effect of pyrroloquinoline quinone against alcoholic liver injury through activating Nrf2-mediated antioxidant and inhibiting TLR4-mediated inflammation responses. Process Biochemistry 2020;92:303
    https://doi.org/10.1016/j.procbio.2020.01.023
  18. Jinhui Sun, Baolong Li, Antao Sun, Kunpeng Zhao, Yanchun Ma, Jiuli Zhao, Hui Pan, Qingrui Song, Yan Wang, Chunyu Yu, Cui Wang, Huan Zhang, Wenwen Zhang, Chenfan Kong. Comprehensive analysis of aberrantly expressed profiles of messenger RNA in alcoholic liver disease. J of Cellular Biochemistry 2019;120:4248
    https://doi.org/10.1002/jcb.27710
  19. Dhadhang Wahyu Kurniawan, Gert Storm, Jai Prakash, Ruchi Bansal. Role of spleen tyrosine kinase in liver diseases. WJG 2020;26:1005
    https://doi.org/10.3748/wjg.v26.i10.1005
  20. Yiling Zheng, Fan Wu, Weiqi Rong, Yunhe Liu, Tana Siqin, Liming Wang, Jianxiong Wu. Prognostic value of the controlling nutritional status (CONUT) score in intrahepatic cholangiocarcinoma patients especially who had long-time alcohol consumption. J. Clin. Biochem. Nutr. 2020;67:323
    https://doi.org/10.3164/jcbn.20-27
  21. Anna Blázovics. Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases. 2020.
    https://doi.org/10.1016/B978-0-12-816488-4.00010-3
  22. Søren Møller, Nina Kimer, Mads Barløse, Flemming Bendtsen. Pathophysiological-based treatments of complications of cirrhosis. Scandinavian Journal of Gastroenterology 2020;55:383
    https://doi.org/10.1080/00365521.2020.1744709
  23. Ruofan Liu, Cuiyuan Mo, Xuetuan Wei, Aimin Ma. Hepatoprotective Effect of Annulohypoxylon stygium Melanin on Acute Alcoholic Liver Injury in Mice. Appl Biochem Biotechnol 2024;196:6395
    https://doi.org/10.1007/s12010-024-04863-0
  24. Bin Gao, Xiaogang Xiang, Lorenzo Leggio, George F. Koob. The Liver. 2024.
    https://doi.org/10.1002/9781119436812.ch53
  25. Ranjith Balakrishnan, Vajagathali Mohammed, Ramakrishnan Veerabathiran. The role of genetic mutation in alcoholic liver disease. Egypt Liver Journal 2022;12
    https://doi.org/10.1186/s43066-022-00175-2
  26. Hannah M. Dix, Emma M. Robinson, John F. Dillon. Textbook of Addiction Treatment. 2022.
    https://doi.org/10.1007/978-3-030-36391-8_77
  27. S.H. Priyanka, A.J. Thushara, Arun A. Rauf, M. Indira. Alcohol induced NLRP3 inflammasome activation in the brain of rats is attenuated by ATRA supplementation. Brain, Behavior, & Immunity - Health 2020;2:100024
    https://doi.org/10.1016/j.bbih.2019.100024
  28. Margret Alm, Viola Andresen, Christian Ell, Christiane Fibbe, Wolfgang Fischbach, Jutta Keller, PH. Frank Kipp, Andrea May, Stephan Miehlke, Rainer Porschen, Andreas Stallmach, Thomas Weinke, Niklas Aehling, Margret Alm, Viola Andresen, Daniel C. Baumgart, Franziska Bertram, Albrecht Böhlig, Catharina Bullmann, Johanna Carstensen, Marie de Greck, Wienke Ellerbeck, Giulia Enders, Christiane Fibbe, Wolfgang Fischbach, Korinna Fritz, Antonia Gaus, Laura Gottschalk, Kai Daniel Grandt, Utah-Maria Henniges, Toni Herta, Dorothea Jasper, Jutta Keller, Nina Kschowak, Konstantin Lang, Alina Lange, Peter Layer, Niels Liedtke, Janek Luttermann, Lida Mancke, Viola Sophie Meier, Ulrike Melle, Daniela Menge, Stefan Michaelis, Sara Nader, Tim-Alexander Niedergassel, Carsten Pachmann, Rainer Porschen, Solveig Rose, Ulrich Rosien, Martin Rössle, Melina Schellhorn, Oliver Schnell, Sebastian Schulz, Julian Siegel, Alexander Stein, Johannes Szuba, Sarah Teising, Stephanie Thiel, Julia Thomas-Morr, Henriette Tillmann, Friederike Todt, Rhea Veelken, Henrike von Schassen, Michael Wölfel, Susanna Wolf, Valentin Wolgast, Clara Wübbolding, Kathrin Zimmermann. Facharztwissen Gastroenterologie und Hepatologie. 2020.
    https://doi.org/10.1016/B978-3-437-21252-9.00011-0
  29. M. Martinez-Castillo, I. Altamirano-Mendoza, S. Sánchez-Valle, L. García-Islas, M. Sánchez-Barragán, M. Hernández-Santillán, A. Hernández-Barragán, J.L. Pérez-Hernández, F. Higuera-de la Tijera, G. Gutierrez-Reyes. Immune dysregulation and pathophysiology of alcohol consumption and alcoholic liver disease. Revista de Gastroenterología de México (English Edition) 2023;88:136
    https://doi.org/10.1016/j.rgmxen.2023.03.003
  30. Hong Ki Min, Hyonjoung Cho, Sung-Hwan Park. Pilot study: asymptomatic hyperuricemia patients with obesity and nonalcoholic fatty liver disease have increased risk of double contour sign . Korean J Intern Med 2020;35:1517
    https://doi.org/10.3904/kjim.2018.448
  31. Nada A.M. Ali, Amir Mohamed Abdelhamid, Norhan M. El-Sayed, Asmaa Radwan. Alpha-Asarone attenuates alcohol-induced hepatotoxicity in a murine model by ameliorating oxidative stress, inflammation, and modulating apoptotic-Autophagic cell death. Toxicology and Applied Pharmacology 2024;490:117041
    https://doi.org/10.1016/j.taap.2024.117041
  32. Vetriselvan Subramaniyan, Srikumar Chakravarthi, Ravindran Jegasothy, Wu Yuan Seng, Neeraj Kumar Fuloria, Shivkanya Fuloria, Iswar Hazarika, Anju Das. Alcohol-associated liver disease: A review on its pathophysiology, diagnosis and drug therapy. Toxicology Reports 2021;8:376
    https://doi.org/10.1016/j.toxrep.2021.02.010
  33. Xiu-Feng Yu, Zeng-Li Zhou, Xu-Dong Lu, Si-Qin Long. Hepatoprotective effect of naringenin in rats with alcoholic liver disease. WCJD 2021;29:1334
    https://doi.org/10.11569/wcjd.v29.i23.1334
  34. Jong-Hwa Kim, Dohyun Woo, YoHan Nam, Jihye Baek, Ji-Yeon Lee, Wonyong Kim. Probiotic cheese improves alcohol metabolism and alleviates alcohol-induced liver injury via the SIRT1/AMPK signaling pathway. Journal of Functional Foods 2023;108:105736
    https://doi.org/10.1016/j.jff.2023.105736
  35. Chenchen Bi, Wenwen Han, Jingru Yu, Huafang Zhang, Guiying Xing, Zheng Liu. Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases. Heliyon 2023;9:e15609
    https://doi.org/10.1016/j.heliyon.2023.e15609
  36. JiXiao Zhu, JiaLing Shan, Xiang Ouyang, HaiYan Yang, RongRui Wei, JinXiang Zeng, HongYu Cheng. Involvement of toll-like receptor 2/myeloid differentiation factor 88/nuclear factor kappa B/NLR family pyrin domain-containing 3 signaling pathways in the hepatoprotective effect of Lagotis brachystachys in rats with alcoholic liver disease. Phcog Mag 2020;16:518
    https://doi.org/10.4103/pm.pm_557_19
  37. Ying Wu, Cheng Li, Yinyin Gao, Jie Zhang, Yao Dong, Lina Zhao, Yuwan Li, Shaobin Gu. Weizmannia coagulans BC99 Attenuates Oxidative Stress Induced by Acute Alcoholic Liver Injury via Nrf2/SKN-1 Pathway and Liver Metabolism Regulation. Antioxidants 2025;14:117
    https://doi.org/10.3390/antiox14010117
  38. Nattapong Jongjitphisut, Rianthong Phumsuay, Worathat Thitikornpong, Paitoon Rashatasakhon, Chawanphat Muangnoi, Opa Vajragupta, Pornchai Rojsitthisak. Synthesis, physicochemical properties, and protective effects of a novel water-soluble tetrahydrocurcumin-diglutaric acid prodrug on ethanol-induced toxicity in HepG2 cells. J. Pharm. Investig. 2022;52:477
    https://doi.org/10.1007/s40005-022-00576-w
  39. Bingjian Wen, Chengcheng Zhang, Jingwen Zhou, Zhengyan Zhang, Qishi Che, Hua Cao, Yan Bai, Jiao Guo, Zhengquan Su. Targeted treatment of alcoholic liver disease based on inflammatory signalling pathways. Pharmacology & Therapeutics 2021;222:107752
    https://doi.org/10.1016/j.pharmthera.2020.107752
  40. Mohamed Tausif Siddiqui, Gail A.M. Cresci. Microbiota reprogramming for treatment of alcohol-related liver disease. Translational Research 2020;226:26
    https://doi.org/10.1016/j.trsl.2020.07.004
  41. Zhejin Li, Zejiang Pu, Yuanwei Gao, Min Zhou, Ziheng Zhang, Pengfei Xiao, Jinting Chen, Chengyan Zhou. Integrated serum and liver metabolomics decipher the hepatoprotective mechanisms of mangiferin sodium salt through modulating alcohol metabolism on alcoholic liver disease. Food Bioscience 2024;61:104631
    https://doi.org/10.1016/j.fbio.2024.104631
  42. Carina Guidi Pinto, Kátia Colombo Marchi, Ailton Amarante Arizza, Ana Paula Silveira Leite, Carlos Renato Tirapelli, Selma Maria Michelin Matheus. Cholecalciferol in ethanol-preferring rats muscle fibers increases the number and area of type II fibers. Acta Histochemica 2018;120:789
    https://doi.org/10.1016/j.acthis.2018.09.004
  43. Pragyan Acharya, Komal Chouhan, Sabine Weiskirchen, Ralf Weiskirchen. Cellular Mechanisms of Liver Fibrosis. Front. Pharmacol. 2021;12
    https://doi.org/10.3389/fphar.2021.671640
  44. Rui Guo, Lin Chen, Jinyan Zhu, Jiaomei Li, Qingchao Ding, Kaixin Chang, Qiang Han, Songtao Li. Monounsaturated fatty acid-enriched olive oil exacerbates chronic alcohol-induced hepatic steatosis and liver injury in C57BL/6J mice. Food Funct. 2023;14:1573
    https://doi.org/10.1039/D2FO03323B
  45. Wang Zhang, Yujun Zhou, Xiuli Xu, Yaping Tian, Chunyan Zhang. A Time-Resolved-Fluorescence Lateral Flow Assay for Rapid Detection of Cholyglycine Acid for the Diagnosis of Liver Diseases. j biomater tissue eng 2021;11:2023
    https://doi.org/10.1166/jbt.2021.2781
  46. Hugo Christian Monroy-Ramirez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Alejandra Meza-Rios, Arturo Santos, Juan Armendariz-Borunda. PPARs as Metabolic Sensors and Therapeutic Targets in Liver Diseases. IJMS 2021;22:8298
    https://doi.org/10.3390/ijms22158298
  47. Arvin Iracheta‐Vellve, Charles D. Calenda, Jan Petrasek, Aditya Ambade, Karen Kodys, Luciano Adorini, Gyongyi Szabo. FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice. Hepatology Communications 2018;2:1379
    https://doi.org/10.1002/hep4.1256
  48. Thomas W. Meeks, Nicole M. Bekman, Nicole M. Lanouette, Kathryn A. Yung, Ryan P. Vienna. Veteran Psychiatry in the US. 2018.
    https://doi.org/10.1007/978-3-030-05384-0_9
  49. Brian Thanh Nguyen, Vy Hoang Nguyen, Michael Le, Linda Henry, Ramsey Cheung, Mindie H. Nguyen. Impact of Income-to-Poverty Ratio on Long-Term Mortality of Persons with Chronic Liver Disease in the USA, 1999–2018. Dig Dis 2024;42:473
    https://doi.org/10.1159/000539858
  50. Xingtao Zhao, Liao Li, Mengting Zhou, Meichen Liu, Ying Deng, Linfeng He, Chaocheng Guo, Yunxia Li, Hongwei Zhang. An Overview of the Mechanism of Penthorum chinense Pursh on Alcoholic Fatty Liver. Evidence-Based Complementary and Alternative Medicine 2020;2020
    https://doi.org/10.1155/2020/4875764
  51. Mary Kate Sullivan, Halim Bou Daher, Don C. Rockey. Normal or near normal aminotransferase levels in patients with alcoholic cirrhosis. The American Journal of the Medical Sciences 2022;363:484
    https://doi.org/10.1016/j.amjms.2021.09.012
  52. Qi Song, Junxia Guo, Yanzhen Zhang, Wen Chen. The beneficial effects of taurine in alleviating fatty liver disease. Journal of Functional Foods 2021;77:104351
    https://doi.org/10.1016/j.jff.2020.104351
  53. Peter C. Konturek, Igor A. Harsch, Kathrin Konturek, Monic Schink, Yurdagül Zopf. Leber-Darm-Achse: Wie Darmbakterien die Leber beeinflussen. MMW - Fortschritte der Medizin 2018;160:11
    https://doi.org/10.1007/s15006-018-1051-6
  54. Jinsol Han, Chanbin Lee, Jin Hur, Youngmi Jung. Current Therapeutic Options and Potential of Mesenchymal Stem Cell Therapy for Alcoholic Liver Disease. Cells 2022;12:22
    https://doi.org/10.3390/cells12010022
  55. Hai-Di Li, Xin Chen, Jie-Jie Xu, Xiao-Sa Du, Yang Yang, Juan-Juan Li, Xiao-Juan Yang, Hui-Min Huang, Xiao-Feng Li, Ming-Fei Wu, Chong Zhang, Chao Zhang, Zeng Li, Hua Wang, Xiao-Ming Meng, Cheng Huang, Jun Li. DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway. 2020;134:1935
    https://doi.org/10.1042/CS20200031
  56. Parita Virendra Patel, Steven L. Flamm. Alcohol-Related Liver Disease Including New Developments. Clinics in Liver Disease 2023;27:157
    https://doi.org/10.1016/j.cld.2022.08.005
  57. Derek Fischer, Ping Ouyang. Lifestyle-Related Factors for Improving Diet Quality. Nutrients 2025;17:448
    https://doi.org/10.3390/nu17030448
  58. David Adesanya O, Adebimpe Esther Ofu, Paul Olugbemiga, Gracious Oluwamayow, Taiwo Adekemi Ab, Tolulope Adefola Ed. Microstructural Effects of Celosia trigyna Leave Extracts on the Liver and Ileum in Ethanol-induced Toxicity in Adult Wistar Rats. Research J. of Medicinal Plants 2020;14:64
    https://doi.org/10.3923/rjmp.2020.64.71
  59. Xiaoxu Wang, Yuliu Wang, Yanjun Liu, Peixu Cong, Jie Xu, Changhu Xue. Hepatoprotective effects of sea cucumber ether-phospholipids against alcohol-induced lipid metabolic dysregulation and oxidative stress in mice. Food Funct. 2022;13:2791
    https://doi.org/10.1039/D1FO03833H
  60. Fien A. von Meijenfeldt, Craig N. Jenne. Netting Liver Disease: Neutrophil Extracellular Traps in the Initiation and Exacerbation of Liver Pathology. Semin Thromb Hemost 2020;46:724
    https://doi.org/10.1055/s-0040-1715474
  61. Francisco Idalsoaga, Ashwani K. Singal, Marco Arrese, Juan P. Arab. Treatment and Management of Tropical Liver Disease. 2020.
    https://doi.org/10.1016/B978-0-323-87031-3.00032-9
  62. Mark G. Swain, David E. J. Jones. Fatigue in chronic liver disease: New insights and therapeutic approaches. Liver International 2019;39:6
    https://doi.org/10.1111/liv.13919
  63. Kusum Kharbanda, Martin Ronis, Colin Shearn, Dennis Petersen, Samir Zakhari, Dennis Warner, Ariel Feldstein, Craig McClain, Irina Kirpich. Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress. Biomolecules 2018;8:16
    https://doi.org/10.3390/biom8020016
  64. Xuelong Li, Ying Liu, Xiaofei Guo, Yan Ma, Huaqi Zhang, Hui Liang. Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury. Eur J Clin Nutr 2021;75:1227
    https://doi.org/10.1038/s41430-020-00852-8
  65. Elie R. Chalhoub, Joanne M. Belovich. Quantitative analysis of the interaction of ethanol metabolism with gluconeogenesis and fatty acid oxidation in the perfused liver of fasted rats. Archives of Biochemistry and Biophysics 2022;718:109148
    https://doi.org/10.1016/j.abb.2022.109148
  66. Ayfer Beyaz Coşkun, Adviye Gülçin Sağdiçoğlu Celep. Therapeutic modulation methods of gut microbiota and gut-liver axis. Critical Reviews in Food Science and Nutrition 2022;62:6505
    https://doi.org/10.1080/10408398.2021.1902263
  67. Chien-Yu Lin, Evanthia Omoscharka, Yanli Liu, Kun Cheng. Establishment of a Rat Model of Alcoholic Liver Fibrosis with Simulated Human Drinking Patterns and Low-Dose Chemical Stimulation. Biomolecules 2023;13:1293
    https://doi.org/10.3390/biom13091293
  68. Xia Li, Quan Jin, Yu Zhang, Yan-Ling Wu, Cheng-Min Jin, Ben-Wen Cui, Ying Li, Ming-Ji Jin, Yue Shang, Min Jiang, Hong-Xu Yang, Mei Wu, Jian Liu, Li-Hua Lian, Ji-Xing Nan. Inhibition of P2X7R–NLRP3 Inflammasome Activation by Pleurotus citrinopileatus: A Possible Protective Role in Alcoholic Hepatosteatosis. J. Agric. Food Chem. 2018;66:13183
    https://doi.org/10.1021/acs.jafc.8b05756
  69. Anna Rycyk-Bojarzynska, Beata Kasztelan-Szczerbinska, Halina Cichoz-Lach, Agata Surdacka, Jacek Rolinski. Neutrophil PAD4 Expression and Its Pivotal Role in Assessment of Alcohol-Related Liver Disease. IJMS 2024;25:7597
    https://doi.org/10.3390/ijms25147597
  70. Na-kyung Cho, Yu-ri Lee, Kyung-soon Kim, Hong-sik Choi, Seung-mo Kim, Young-doo Back, Byung-kwon Moon. A Review of Domestic Research on Traditional Korean Medicine for Alcoholic Liver Disease. J Int Korean Med 2019;40:458
    https://doi.org/10.22246/jikm.2019.40.3.458
  71. Yandi Xie, Zilong Wang, Guangjun Song, Hui Ma, Bo Feng. GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction. Cell Div 2024;19
    https://doi.org/10.1186/s13008-024-00114-0
  72. Xudan Li, Xuan Li, Yuan Deng, Lianghua Chen, Zhizhong Zheng, Yanlin Ming. Protective Effect of Corilagin on Alcoholic Liver Injury. Natural Product Communications 2024;19
    https://doi.org/10.1177/1934578X241257089
  73. Xiuyan Wang, Endian Zheng, Haoyue Sun, Beibei Xu, Liang Zheng, Yi Huang. Efficacy of prophylactic antibiotics in the adjuvant treatment of alcohol-related liver disease (ALD): A systematic review and meta-analysisProphylactic antibiotics in ALD. Annals of Hepatology 2025;30:101571
    https://doi.org/10.1016/j.aohep.2024.101571
  74. Anna Rycyk-Bojarzyńska, Beata Kasztelan-Szczerbińska, Halina Cichoż-Lach, Agata Surdacka, Jacek Roliński. Human Neutrophil Alpha-Defensins Promote NETosis and Liver Injury in Alcohol-Related Liver Cirrhosis: Potential Therapeutic Agents. JCM 2024;13:1237
    https://doi.org/10.3390/jcm13051237
  75. Fengxian Luo, Beiwei Zhu, Di Wu, Yu Xu, Tao Chen, Yanfei Li, Jiangning Hu. Construction of Phlorotannin-Based Nanoparticles for Alleviating Acute Liver Injury. ACS Appl. Mater. Interfaces 2023;15:47338
    https://doi.org/10.1021/acsami.3c05407
  76. Ivan Stève Tsopmejio Nguepi, Florence Tsofack Ngueguim, Raceline Kamkumo Gounoue, Adolphe Mbatchou, Theophile Dimo. Curative effects of the aqueous extract of Tithonia diversifolia (Hemsl.) A. gray (Asteraceae) against ethanol induced-hepatotoxicity in rats. 2021;32:1137
    https://doi.org/10.1515/jbcpp-2019-0370
  77. Aleksandra Kołota, Dominika Głąbska, Michał Oczkowski, Joanna Gromadzka-Ostrowska. Oxidative Stress Parameters in the Liver of Growing Male Rats Receiving Various Alcoholic Beverages. Nutrients 2020;12:158
    https://doi.org/10.3390/nu12010158
  78. Yen-Chun Chen, Ping-Hung Ko, Chi-Che Lee, Chih-Wei Tseng, Kuo-Chih Tseng. Baseline thrombopoietin level is associated with platelet count improvement in thrombocytopenic chronic hepatitis C patients after successful direct-acting antiviral agent therapy. BMC Gastroenterol 2021;21
    https://doi.org/10.1186/s12876-021-01606-x
  79. Krushna Baviskar, Aniket Kshirsagar, Hemant Raut, M.R.N Shaikh. Overview: Global burden of liver disease. IJPCA 2024;11:1
    https://doi.org/10.18231/j.ijpca.2024.001
  80. Yu-Lin Wu, Si-Han Huang, Chun-Mei He, Bo Qiu, Jing-Jing Liu, Jia Li, Ying Lin, Sheng-Lu Yu, Hong-Feng Wang, Gui-Fang Zhang, Li Zhang. Dendrobium officinale Flower Extraction Mitigates Alcohol‐Induced Liver Injury in Mice: Role of Antisteatosis, Antioxidative, and Anti‐Inflammatory. Evidence-Based Complementary and Alternative Medicine 2020;2020
    https://doi.org/10.1155/2020/1421853
  81. Akiko Eguchi, Yoshiyuki Takei. Alcoholic/Non-Alcoholic Digestive Diseases. 2020.
    https://doi.org/10.1007/978-981-13-1465-0_6
  82. Constance Marié, Grégory Fouquet, Anoïsia Courtois, Rabbind Singh Amrathlal, Nicolas Jankovsky, Hakim Ouled-Haddou, Riad Tebbakha, Hicham Bouhlal, Éric Nguyen-Khac, Mickaël Naassila, Ingrid Marcq. Mechanisms of chronic alcohol exposure-induced aggressiveness in cellular model of HCC and recovery after alcohol withdrawal. Cell. Mol. Life Sci. 2022;79
    https://doi.org/10.1007/s00018-022-04387-y
  83. Xianying Fang, Jiamin Cao, Zhi Tao, Zhiqing Yang, Yuan Dai, Linguo Zhao. Hydroxytyrosol attenuates ethanol-induced liver injury by ameliorating steatosis, oxidative stress and hepatic inflammation by interfering STAT3/iNOS pathway. Redox Report 2023;28
    https://doi.org/10.1080/13510002.2023.2187564
  84. Fumio Nomura, Tatsuo Kanda, Masanori Seimiya, Mamoru Satoh, Youko Kageyama, Takeshi Yamashita, Osamu Yokosuka, Naoya Kato, Katsuya Maruyama. Determination of serum carbohydrate-deficient transferrin by a nephelometric immunoassay for differential diagnosis of alcoholic and non-alcoholic liver diseases. Clinica Chimica Acta 2018;485:181
    https://doi.org/10.1016/j.cca.2018.06.040
  85. Jan Korbecki, Iwona Szatkowska, Patrycja Kupnicka, Wojciech Żwierełło, Katarzyna Barczak, Iwona Poziomkowska-Gęsicka, Jerzy Wójcik, Dariusz Chlubek, Irena Baranowska-Bosiacka. The Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Oral Cavity and Abdominal Organs. IJMS 2022;23:7151
    https://doi.org/10.3390/ijms23137151
  86. Chloe Attree, Sean Fennessy, Gary Jeffrey, Nickolas Kontorinis, Nola Naylor, Simon Hazeldine. Prior hospital attendances in deceased Australian patients with alcohol‐related liver disease: a multicentre project. Internal Medicine Journal 2024;54:1003
    https://doi.org/10.1111/imj.16339
  87. A. Figueroa Tubío, J.C. Ruiz Cobo, L. Téllez Villajos, R. Martín-Mateos. Enfermedad hepática inducida por alcohol. Medicine - Programa de Formación Médica Continuada Acreditado 2020;13:182
    https://doi.org/10.1016/j.med.2020.02.002
  88. Roya Karamian, Mostafa Asadbegy, Siamak Yari. Protective potency of Meristotropis xanthioides against nephrotoxicity in a rat model along with its antioxidant and antibacterial activities. Asian Pacific Journal of Tropical Medicine 2017;10:960
    https://doi.org/10.1016/j.apjtm.2017.09.007
  89. Salma Mukhtar Mir, Bidya Dhar Sahu, Meghana Koneru, Madhusudana Kuncha, Mahesh Kumar Jerald, Halley Gora Ravuri, Sanjit Kanjilal, Ramakrishna Sistla. Supplementation of oat ( Avena sativa L.) extract abates alcohol-induced acute liver injury in a mouse model. Nutrition Research 2018;54:80
    https://doi.org/10.1016/j.nutres.2018.04.002
  90. Helmut K. Seitz, Ramon Bataller, Helena Cortez-Pinto, Bin Gao, Antoni Gual, Carolin Lackner, Philippe Mathurin, Sebastian Mueller, Gyongyi Szabo, Hidekazu Tsukamoto. Alcoholic liver disease. Nat Rev Dis Primers 2018;4
    https://doi.org/10.1038/s41572-018-0014-7
  91. Sabine Hoffmann, Sarah Gerhardt, Anne Koopmann, Patrick Bach, Wolfgang H. Sommer, Falk Kiefer, Massimiliano Mazza, Bernd Lenz. Body mass index interacts with sex to predict readmission in in‐patients with alcohol use disorder. Addiction Biology 2023;28
    https://doi.org/10.1111/adb.13239
  92. Hamish Innes, Felix Stickel. Alcohol and Alcohol-related Diseases. 2023.
    https://doi.org/10.1007/978-3-031-32483-3_52
  93. Giuseppe Marano, Gianandrea Traversi, Eleonora Gaetani, Roberto Pola, Angelo Emilio Claro, Marianna Mazza. Alcohol use disorder and liver injury related to the COVID-19 pandemic. World J Hepatol 2022;14:1875
    https://doi.org/10.4254/wjh.v14.i10.1875
  94. Zili Zhang, Zhen Yao, Yifan Chen, Lei Qian, Shuoyi Jiang, Jingyi Zhou, Jiangjuan Shao, Anping Chen, Feng Zhang, Shizhong Zheng. Lipophagy and liver disease: New perspectives to better understanding and therapy. Biomedicine & Pharmacotherapy 2018;97:339
    https://doi.org/10.1016/j.biopha.2017.07.168
  95. Ying Wei, Mingliang Li, Zhiyuan Feng, Di Zhang, Meiling Sun, Yong Wang, Xiangning Chen. The Protective Effects of Corn Oligopeptides on Acute Alcoholic Liver Disease by Inhibiting the Activation of Kupffer Cells NF-κB/AMPK Signal Pathway. Nutrients 2022;14:4194
    https://doi.org/10.3390/nu14194194
  96. Sharad Maheshwari, Chris N. Gu, Melanie P. Caserta, Camille A. Kezer, Vijay H. Shah, Michael S. Torbenson, Christine O. Menias, Jeff L. Fidler, Sudhakar K. Venkatesh. Imaging of Alcohol-Associated Liver Disease. American Journal of Roentgenology 2024;222
    https://doi.org/10.2214/AJR.23.29917
  97. David A. Areshidze, Lev V. Kaktursky, Lyudmila M. Mikhaleva, Maria A. Kozlova. The effects of dark deprivation and chronic alcohol intoxication on the liver of rats. Morphology 2024;161:23
    https://doi.org/10.17816/morph.623050
  98. Yonglin Chen, Xinshou Ouyang, Rafaz Hoque, Irma Garcia-Martinez, Muhammad Nadeem Yousaf, Sarah Tonack, Stefan Offermanns, Laurent Dubuquoy, Alexandre Louvet, Philippe Mathurin, Veronica Massey, Bernd Schnabl, Ramon Alberola Bataller, Wajahat Zafar Mehal. β-Hydroxybutyrate protects from alcohol-induced liver injury via a Hcar2-cAMP dependent pathway. Journal of Hepatology 2018;69:687
    https://doi.org/10.1016/j.jhep.2018.04.004
  99. Kemper Nunes dos Santos, Rodrigo M. Florentino, Andressa França, Antônio Carlos Melo Lima Filho, Marcone Loiola dos Santos, Dabny Missiaggia, Matheus de Castro Fonseca, Igor Brasil Costa, Paula Vieira Teixeira Vidigal, Michael H. Nathanson, Fernanda de Oliveira Lemos, M. Fatima Leite. Polymorphism in the Promoter Region of NFE2L2 Gene Is a Genetic Marker of Susceptibility to Cirrhosis Associated with Alcohol Abuse. IJMS 2019;20:3589
    https://doi.org/10.3390/ijms20143589
  100. Xuemei Zhang, Wenqi Song, Mingxuan Zhang, Yuanhang Song, Yuzhu Di, Bo Chen, Hao Tian, Xixian Yuan, Shizhu Jin. Identification of differentially expressed miRNAs and key genes involved in the progression of alcoholic fatty liver disease using rat models. Clinics and Research in Hepatology and Gastroenterology 2022;46:102012
    https://doi.org/10.1016/j.clinre.2022.102012
  101. Pawel Hikisz, Damian Jacenik. Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases. IJMS 2023;24:6579
    https://doi.org/10.3390/ijms24076579
  102. Yen-Chun Chen, Chen-Hao Li, Ping-Hung Ko, Chi-Che Lee, Ru-Jiang Syu, Chih-Wei Tseng, Kuo-Chih Tseng, Chen-Hua Liu. Neutrophil gelatinase-associated lipocalin partly reflects the dynamic changes of renal function among chronic hepatitis C patients receiving direct-acting antivirals. PLoS ONE 2021;16:e0256505
    https://doi.org/10.1371/journal.pone.0256505
  103. Eduardo Medeiros de Araujo, Ulysses S. Torres, Douglas Jorge Racy, Lucas Rios Torres, Rubens Chojniak, Giuseppe D’Ippolito. The “streamline phenomenon” of the portal vein flow and its influence on liver involvement by gastrointestinal diseases: current concepts and imaging-based review. Abdom Radiol 2020;45:403
    https://doi.org/10.1007/s00261-019-02335-2
  104. Joshua A. Bornhorst, Gwendolyn McMillin. Critical Issues in Alcohol and Drugs of Abuse Testing. 2020.
    https://doi.org/10.1016/B978-0-12-815607-0.00004-6
  105. Min Guo, Liwei Gu, Heping Hui, Xiaodong Li, Ling Jin. Extracts of Dracocephalum tanguticum Maxim Ameliorate Acute Alcoholic Liver Disease via Regulating Transcription Factors in Mice. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.830532
  106. Brigita Smolovic, Batric Vukcevic, Damir Muhovic, Marina Ratkovic. Renal aspergillosis in a liver transplant patient: A case report and review of literature. WJCC 2018;6:1155
    https://doi.org/10.12998/wjcc.v6.i16.1155
  107. Xavier Xiol Quingles, Sílvia Salord Vila, Alberto Amador Navarrete, Carme Baliellas Comellas, Alba Cachero Ros, Rosa Rota Roca, Valeria Pérez Campuzano, José Castellote Alonso. Quality of care provided to outpatients with hepatic cirrhosis in a teaching hospital. Rev Esp Enferm Dig 2020
    https://doi.org/10.17235/reed.2020.6811/2019
  108. Xiao-jing Song, Shu-you Wang, Shu-yong Jia, Guang-jun Wang, Wei-bo Zhang. Effects of electroacupuncture on liver function in mice with chronic alcoholic liver injury: visual display by in vivo fluorescence imaging. Acupunct Med 2023;41:215
    https://doi.org/10.1177/09645284221125248
  109. Anna Licata, Giuseppina T. Russo, Annalisa Giandalia, Marcella Cammilleri, Clelia Asero, Irene Cacciola. Impact of Sex and Gender on Clinical Management of Patients with Advanced Chronic Liver Disease and Type 2 Diabetes. JPM 2023;13:558
    https://doi.org/10.3390/jpm13030558
  110. Gustavo Ayares, Francisco Idalsoaga, Luis A. Díaz, Jorge Arnold, Juan P. Arab. Current Medical Treatment for Alcohol-Associated Liver Disease. Journal of Clinical and Experimental Hepatology 2022;12:1333
    https://doi.org/10.1016/j.jceh.2022.02.001
  111. Selver Ozekinci. Medicolegal Aspect of Alcohol. 2022.
    https://doi.org/10.69860/nobel.9786053359487.3
  112. Elizabeth L. Godfrey, Rise Stribling, Abbas Rana. Liver Transplantation for Alcoholic Liver Disease. Clinics in Liver Disease 2019;23:127
    https://doi.org/10.1016/j.cld.2018.09.007
  113. Javad Mahmoudi, Ata Mahmoodpoor, Mehdi Amirnia, Tohid Kazemi, Pooneh Chokhachi Baradaran, Shirin Sheikh Najafi, Saeed Sadigh‐Eteghad, Fereshteh Farajdokht, Huaxi Xu, Mobina Belalzadeh, Siamak Sandoghchian Shotorbani. The induced decrease in TLR2 and TLR4 by cerebrolysin in the alcoholic liver of rats. Journal Cellular Physiology 2019;234:16290
    https://doi.org/10.1002/jcp.28293
  114. Mark Thursz, Antoni Gual, Caroline Lackner, Philippe Mathurin, Christophe Moreno, Laurent Spahr, Martina Sterneck, Helena Cortez-Pinto. EASL Clinical Practice Guidelines: Management of alcohol-related liver disease. Journal of Hepatology 2018;69:154
    https://doi.org/10.1016/j.jhep.2018.03.018
  115. Ling-Zu Kong, Nisansala Chandimali, Ying-Hao Han, Dong-Ho Lee, Ji-Su Kim, Sun-Uk Kim, Tae-Don Kim, Dong Kee Jeong, Hu-Nan Sun, Dong Sun Lee, Taeho Kwon. Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease. IJMS 2019;20:2712
    https://doi.org/10.3390/ijms20112712
  116. Garima Mishra, Pradeep Singh, Mulugeta Molla, Yohannes Shumet Yimer, Subas Chandra Dinda, Phool Chandra, Bhuvnesh Kumar Singh, Samuel Berihun Dagnew, Abraham Nigussie Assefa, Amien Ewunetie. Harnessing the potential of probiotics in the treatment of alcoholic liver disorders. Front. Pharmacol. 2023;14
    https://doi.org/10.3389/fphar.2023.1212742
  117. Chenggui Miao, Zhongwen Xie, Jun Chang. Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions. Biochem Genet 2018;56:423
    https://doi.org/10.1007/s10528-018-9870-9
  118. Vyacheslav Buko, Ilya Zavodnik, Grażyna Budryn, Małgorzata Zakłos-Szyda, Elena Belonovskaya, Siarhei Kirko, Dorota Żyżelewicz, Agnieszka Zakrzeska, Aliaksei Bakunovich, Viktor Rusin, Valentina Moroz. Chlorogenic Acid Protects against Advanced Alcoholic Steatohepatitis in Rats via Modulation of Redox Homeostasis, Inflammation, and Lipogenesis. Nutrients 2021;13:4155
    https://doi.org/10.3390/nu13114155
  119. Paul S. Haber, Nicholas C. Kortt. Alcohol use disorder and the gut. Addiction 2021;116:658
    https://doi.org/10.1111/add.15147
  120. Xiaolin Wang, Yanfang Yang, Yuanli Chen, Yajun Duan, Jihong Han, Xiaoxiao Yang. MEK1/2 inhibitors induce class I alcohol dehydrogenase (ADH1) expression by regulating farnesoid X receptor in hepatic cell lines and C57BL/6J mouse. Mol Biol Rep 2022;49:5843
    https://doi.org/10.1007/s11033-022-07361-w
  121. Sunmin Park, Da S Kim, Xuangao Wu, Qiu J Yi. Mulberry and dandelion water extracts prevent alcohol-induced steatosis with alleviating gut microbiome dysbiosis. Exp Biol Med (Maywood) 2018;243:882
    https://doi.org/10.1177/1535370218789068
  122. Hadi Ali, Mohammed A. Assiri, Colin T. Shearn, Kristofer S. Fritz. Lipid peroxidation derived reactive aldehydes in alcoholic liver disease. Current Opinion in Toxicology 2019;13:110
    https://doi.org/10.1016/j.cotox.2018.10.003
  123. Xiaoyi Tan, Yumeng Wang, Mingyu Liu, Jing Gan, Jingwen Wu, Yawen Liang, Guanghua Zhao, Chenyan Lv. Roles of homopolymeric apoferritin in alleviating alcohol-induced liver injury. Food Bioscience 2022;48:101794
    https://doi.org/10.1016/j.fbio.2022.101794
  124. Agata Michalak, Tomasz Lach, Halina Cichoż-Lach. Oxidative Stress—A Key Player in the Course of Alcohol-Related Liver Disease. JCM 2021;10:3011
    https://doi.org/10.3390/jcm10143011
  125. M. Martinez-Castillo, I. Altamirano-Mendoza, S. Sánchez-Valle, L. García-Islas, M. Sánchez-Barragán, M. Hernández-Santillán, A. Hernández-Barragán, J.L. Pérez-Hernández, F. Higuera-de la Tijera, G. Gutierrez-Reyes. Desregulación inmunológica y fisiopatología del consumo de alcohol y la enfermedad hepática alcohólica. Revista de Gastroenterología de México 2023;88:136
    https://doi.org/10.1016/j.rgmx.2023.01.002
  126. Concepción Gómez-Medina, Luma Melo, David Martí-Aguado, Ramón Bataller. Subclinical versus advanced forms of alcohol-related liver disease: Need for early detection. Clin Mol Hepatol 2023;29:1
    https://doi.org/10.3350/cmh.2022.0017
  127. Juan P. Arab, Juan P. Roblero, Jose Altamirano, Fernando Bessone, Roberta Chaves Araujo, Fatima Higuera-De la Tijera, Juan Carlos Restrepo, Aldo Torre, Alvaro Urzua, Douglas A. Simonetto, Juan G. Abraldes, Nahum Méndez-Sánchez, Fernando Contreras, Michael R. Lucey, Vijay H. Shah, Helena Cortez-Pinto, Ramon Bataller. Alcohol-related liver disease: Clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH). Annals of Hepatology 2019;18:518
    https://doi.org/10.1016/j.aohep.2019.04.005
  128. Aishah Abdullah AL-Qahtani, Ali Abdullah Shati, Amin A. Al-Doaiss, Fahmy Gad Elsaid. Mitigating alcohol-induced neurohepatotoxicity in male albino rats with avocado and mustard. J.Umm Al-Qura Univ. Appll. Sci. 2024;10:530
    https://doi.org/10.1007/s43994-024-00124-2
  129. Ji-Hee Haam, Yang-Im Hur, Young-Sang Kim, Kyoung-Kon Kim, Jee-Hyun Kang, Hae-Jin Ko, Yoon Jeong Cho, Hye-In Choi, Kyu Rae Lee, Jung Ha Park, Soo Hyun Cho, Jong-Koo Kim, Taesic Lee, Myung-Jae Seo, Yeong Sook Yoon, Yoobin Seo, Ga Eun Nam, Sun Hyun Kim. Fatty Liver Change in Korean Adults in a Systematic Social Distancing System Amid the COVID-19 Pandemic: A Multicenter Analysis. IJERPH 2022;19:10444
    https://doi.org/10.3390/ijerph191610444
  130. Lucija Virovic-Jukic, Dominik Ljubas, Sanja Stojsavljevic-Shapeski, Neven Ljubičić, Tajana Filipec Kanizaj, Ivana Mikolasevic, Ivica Grgurevic. Liver regeneration as treatment target for severe alcoholic hepatitis. WJG 2022;28:4557
    https://doi.org/10.3748/wjg.v28.i32.4557
  131. Ling Zhu, Jiawei Geng, An Xiao. Drug-induced severe liver injury due to Sterculia versicolor: a case report with causality assessment from possible to probable. J Biomed Res 2022;36:215
    https://doi.org/10.7555/JBR.36.20220044
  132. Jihee Kim, Min-Jeong Kim, Jin-Ho Lee, Keunjung Woo, Minah Kim, Tack-Joong Kim, Daniel Dias Rufino Arcanjo. Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats. Evidence-Based Complementary and Alternative Medicine 2021;2021:1
    https://doi.org/10.1155/2021/6643345
  133. Harsh Kumar, Daljeet Singh Dhanjal, Shivani Guleria, Eugenie Nepovimova, Nidhi Sethi, Rajni Dhalaria, Kamil Kuca. Hepatoprotective effects of fruits pulp, seed, and peel against chemical-induced toxicity: Insights from in vivo studies. Food and Chemical Toxicology 2024;189:114742
    https://doi.org/10.1016/j.fct.2024.114742
  134. Veronica L. Massey, Liya Qin, Joaquin Cabezas, Juan Caballeria, Pau Sancho‐Bru, Ramon Bataller, Fulton T. Crews. TLR7‐let‐7 Signaling Contributes to Ethanol‐Induced Hepatic Inflammatory Response in Mice and in Alcoholic Hepatitis. Alcoholism Clin & Exp Res 2018;42:2107
    https://doi.org/10.1111/acer.13871
  135. Do Seon Song. Medical Treatment of Alcoholic Liver Disease. Korean J Gastroenterol 2020;76:65
    https://doi.org/10.4166/kjg.2020.76.2.65
  136. Amreen Dinani, Ali Khan, Douglas Dieterich. Emerging Prevalence of Fatty Liver Disease in HIV. Future Virol. 2021;16:59
    https://doi.org/10.2217/fvl-2020-0184
  137. Yuan Song, Xiangqun Wu, Di Yang, Fang Fang, Lingshi Meng, Ya Liu, Weiwei Cui. Protective Effect of Andrographolide on Alleviating Chronic Alcoholic Liver Disease in Mice by Inhibiting Nuclear Factor Kappa B and Tumor Necrosis Factor Alpha Activation. Journal of Medicinal Food 2020;23:409
    https://doi.org/10.1089/jmf.2019.4471
  138. Kwang Yoon Kim, Jung Oh Kim, Young‐Sang Kim, Ja‐Eun Choi, Jae‐Min Park, Kunhee Han, Da‐Hyun Park, Yon Chul Park, Bom Taeck Kim, Kyung‐Won Hong. Genome‐wide association of individual vulnerability with alcohol‐associated liver disease: A Korean genome and epidemiology study. Hepatology 2022;75:391
    https://doi.org/10.1002/hep.32115
  139. Nianan Luo, Jiangbin Li, Rui Dong, Jianguo Lu, Zhengwen Liu. Exosome-Based Theranostics for Liver Diseases. Disease Markers 2022;2022:1
    https://doi.org/10.1155/2022/7888906
  140. Bokyeong Ryu, Kyung‐Yeon Eo, Ja‐Jun Jang, C‐Yoon Kim, Ji Min Lee, Hanseul Oh, Ukjin Kim, Jin Kim, Hyun‐Ho Lee, Young‐Mok Jung, Jae‐Hak Park. A case of active incomplete biliary cirrhosis in an aged female Japanese macaque (Macaca fuscata). J of Medical Primatology 2018;47:270
    https://doi.org/10.1111/jmp.12347
  141. Tiffany Wu, Timothy R. Morgan, Andrew S. Klein, Michael L. Volk, Sammy Saab, Vinay Sundaram. Controversies in Early Liver Transplantation for Severe Alcoholic Hepatitis. Annals of Hepatology 2018;17:759
    https://doi.org/10.5604/01.3001.0012.3134
  142. Ling Wang, Hong‐Mei You, Hong‐Wu Meng, Xue‐Yin Pan, Xin Chen, Yi‐Hui Bi, Ya‐Fei Zhang, Juan‐Juan Li, Na‐Na Yin, Zheng‐Wei Zhang, Cheng Huang, Jun Li. STING‐mediated inflammation contributes to Gao binge ethanol feeding model. Journal Cellular Physiology 2022;237:1471
    https://doi.org/10.1002/jcp.30606
  143. Pierluigi Ramadori, Francisco Cubero, Christian Liedtke, Christian Trautwein, Yulia Nevzorova. Alcohol and Hepatocellular Carcinoma: Adding Fuel to the Flame. Cancers 2017;9:130
    https://doi.org/10.3390/cancers9100130
  144. Bethany R. Chrystoja, Jürgen Rehm, Jean‐François Crépault, Kevin Shield. Effect of alcohol prohibition on liver cirrhosis mortality rates in Canada from 1901 to 1956: A time‐series analysis. Drug and Alcohol Review 2020;39:637
    https://doi.org/10.1111/dar.13089
  145. Ying-Wei Lan, Wan-Ru Chen, Gary Ro-Lin Chang, Ying-Cheng Chen, Kowit-Yu Chong, Kai-Cheng Chuang, Yung-Tsung Kao, Ming-Shan Chen, Chuan-Mu Chen. Aldo-keto reductase family 1 member A1 (AKR1A1) exerts a protective function in alcohol-associated liver disease by reducing 4-HNE accumulation and p53 activation. Cell Biosci 2024;14
    https://doi.org/10.1186/s13578-024-01200-0
  146. Shreya S. Revadi, V. Kavitha, A. Mooventhan. Effect of yoga and naturopathy on liver, renal and cardiorespiratory functions of a patient with hepatic cirrhosis with portal hypertension and ascites: a case report. 2018;15
    https://doi.org/10.1515/jcim-2017-0098
  147. Ivan M. Petyaev, Marina P. Chernyshova, Dmitry V. Pristensky, Natalia E. Chalyk, Victor A. Klochkov, Nigel H. Kyle, Yuriy K. Bashmakov. Effect of Lycosome-Formulated Phosphatidylcholine on Parameters of Biological Oxidation after Single Intake of Moderate Amount of Alcohol. Advances in Preventive Medicine 2018;2018:1
    https://doi.org/10.1155/2018/5840451
  148. Lugao Tian, Fachao Fan, Shihua Zheng, Qiaoyun Tong. Puerarin Exerts the Hepatoprotection from Chronic Alcohol-Induced Liver Injury via Inhibiting the Cyclooxygenase-2 and the 5-Lipoxygenase Pathway in Rats. Complement Med Res 2021;28:104
    https://doi.org/10.1159/000508686
  149. Tilman Sauerbruch, Robert Schierwagen, Jonel Trebicka. Managing portal hypertension in patients with liver cirrhosis. F1000Res 2018;7:533
    https://doi.org/10.12688/f1000research.13943.1
  150. Thomas Bergsmark, Lise Katrine Engesæter, Allan Rasmussen, William Bennet, Arno Nordin, Virge Pall, Pål-Dag Line, Bo-Göran Ericzon, Espen Melum. Long-term survival after liver transplantation for alcohol-related liver disease in the Nordic countries. Scandinavian Journal of Gastroenterology 2023;58:923
    https://doi.org/10.1080/00365521.2023.2184193
  151. Qing Xia, Kechun Liu, Zhili Jia, Xiaobin Li, Shanshan Zhang, Liwen Han, Guijin Sun, Chung-Der Hsiao, Yun Zhang. The hepatoprotective effects of squid gonad phospholipids on fatty liver disease in zebrafish. Food Bioscience 2020;35:100592
    https://doi.org/10.1016/j.fbio.2020.100592
  152. Chen Li, Li Li, Cheng-fang Yang, Yu-juan Zhong, Dan Wu, Lin Shi, Li Chen, Yong-wen Li. Hepatoprotective effects of Methyl ferulic acid on alcohol-induced liver oxidative injury in mice by inhibiting the NOX4/ROS-MAPK pathway. Biochemical and Biophysical Research Communications 2017;493:277
    https://doi.org/10.1016/j.bbrc.2017.09.030
  153. Susan M. Gapstur, Elisa V. Bandera, David H. Jernigan, Noelle K. LoConte, Brian G. Southwell, Vasilis Vasiliou, Abenaa M. Brewster, Timothy S. Naimi, Courtney L. Scherr, Kevin D. Shield. Alcohol and Cancer: Existing Knowledge and Evidence Gaps across the Cancer Continuum. 2022;31:5
    https://doi.org/10.1158/1055-9965.EPI-21-0934
  154. Alok Kumar, Vivek Saraswat, Gaurav Pande, Rajesh Kumar. Does Treatment of Erectile Dysfunction With PDE 5 Inhibitor Tadalafil Improve Quality of Life in Male Patients With Compensated Chronic Liver Disease? A Prospective Pilot Study. Journal of Clinical and Experimental Hepatology 2022;12:1083
    https://doi.org/10.1016/j.jceh.2022.01.009
  155. Amedeo Lonardo, Stefano Ballestri. Perspectives of nonalcoholic fatty liver disease research: a personal point of view. 2020;1:85
    https://doi.org/10.37349/emed.2020.00007
  156. Ashish Dogra, Feng Li. Small-molecule chemical probes for the potential therapeutic targets in alcoholic liver diseases. Liver Research 2023;7:177
    https://doi.org/10.1016/j.livres.2023.09.001
  157. Yen-Chun Chen, Chih-Wei Tseng, Kuo-Chih Tseng. Rapid platelet count improvement in chronic hepatitis C patients with thrombocytopenia receiving direct-acting antiviral agents. 2020;99:e20156
    https://doi.org/10.1097/MD.0000000000020156
  158. Monika Zajkowska, Barbara Mroczko. Chemokines in Primary Liver Cancer. IJMS 2022;23:8846
    https://doi.org/10.3390/ijms23168846
  159. Lina Kong, Renchao Dong, Kai Huang, Xiaohui Wang, Dalong Wang, Nan Yue, Changyuan Wang, Pengyuan Sun, Jiangning Gu, Haifeng Luo, Kexin Liu, Jingjing Wu, Huijun Sun, Qiang Meng. Yangonin modulates lipid homeostasis, ameliorates cholestasis and cellular senescence in alcoholic liver disease via activating nuclear receptor FXR. Phytomedicine 2021;90:153629
    https://doi.org/10.1016/j.phymed.2021.153629
  160. Olorunsola Israel Adeyomoye, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Juliana bunmi Adetunji, Frank Abimbola Ogundolie, John Tsado Mathew, Abel Inobeme. Chitosan-Based Nanoparticles for Biomedical Applications. 2021.
    https://doi.org/10.1016/B978-0-443-13997-0.00028-X
  161. Jeetesh V. Patel, Paramjit Gill. The Liver in Systemic Disease. 2021.
    https://doi.org/10.1002/9781119802181.ch2
  162. Sabine Gufler, Rita Seeboeck, Christoph Schatz, Johannes Haybaeck. The Translational Bridge between Inflammation and Hepatocarcinogenesis. Cells 2022;11:533
    https://doi.org/10.3390/cells11030533
  163. D. V. Garbuzenko. Principles of diagnosis and treatment of alcohol-induced liver fibrosis. Medicinskij sovet 2022:104
    https://doi.org/10.21518/2079-701X-2022-16-7-104-114
  164. Catherine E Kling, James D Perkins, Robert L Carithers, Dennis M Donovan, Lena Sibulesky. Recent trends in liver transplantation for alcoholic liver disease in the United States. WJH 2017;9:1315
    https://doi.org/10.4254/wjh.v9.i36.1315
  165. Hender Rojas. Alcoholic Liver Disease: Implications for the Advanced Practice Provider. The Journal for Nurse Practitioners 2019;15:506
    https://doi.org/10.1016/j.nurpra.2019.04.002
  166. Htar Htar Aung, Saint Nway Aye, Norah Htet Htet, Sarah El-Nakeep, Siang Tong Kew, Chavdar S Pavlov. Human stem cells for decompensated cirrhosis in adults. 2022;2022
    https://doi.org/10.1002/14651858.CD015173
  167. Walter Gottlieb Land. Damage-Associated Molecular Patterns in Human Diseases. 2022.
    https://doi.org/10.1007/978-3-030-53868-2_9
  168. Hsin-Yun Wu, Chuen-Chau Chang, Chun-Chieh Yeh, Ming-Yao Chen, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao. Adverse outcomes after non-hepatic surgeries in patients with alcoholic liver diseases: a propensity-score matched study. BMC Gastroenterol 2022;22
    https://doi.org/10.1186/s12876-022-02558-6
  169. Banishree Saha, Fatemeh Momen‐Heravi, Istvan Furi, Karen Kodys, Donna Catalano, Anwesha Gangopadhyay, Reka Haraszti, Abhishek Satishchandran, Arvin Iracheta‐Vellve, Adeyinka Adejumo, Scott A. Shaffer, Gyongyi Szabo. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90. Hepatology 2018;67:1986
    https://doi.org/10.1002/hep.29732
  170. Bernice Asiedu, Busisani Wiseman Lembede, Monica Gomes, Abe Kasonga, Pilani Nkomozepi, Trevor Tapiwa Nyakudya, Eliton Chivandi. Neonatal Orally Administered Zingerone Attenuates Alcohol-Induced Fatty Liver Disease in Experimental Rat Models. Metabolites 2023;13:167
    https://doi.org/10.3390/metabo13020167
  171. Karina Benderski, Paul Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli, Fabian Kiessling, Matthias Bros, Mustafa Diken, Stephan Grabbe, Jörn M. Schattenberg, Twan Lammers, Alexandros Marios Sofias, Leonard Kaps. A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing. Pharmacological Research 2025;211:107560
    https://doi.org/10.1016/j.phrs.2024.107560
  172. Abdo Mahli, Wolfgang Erwin Thasler, Claus Hellerbrand. Establishment of a p-nitrophenol oxidation-based assay for the analysis of CYP2E1 activity in intact hepatocytes in vitro. Toxicology Mechanisms and Methods 2019;29:219
    https://doi.org/10.1080/15376516.2018.1539800
© 2023. Gut and Liver. / Powered by INFOrang Co., Ltd