GNL Gut and Liver
  1. Candice Mazewski, Morgan Sanha Kim, Elvira Gonzalez de Mejia. Anthocyanins, delphinidin-3-O-glucoside and cyanidin-3-O-glucoside, inhibit immune checkpoints in human colorectal cancer cells in vitro and in silico. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-47903-0
  2. Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Changhee Kang, Jae Young Jang, Heewon Nho, Eun Shin, Ha-Na Lee. Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice. J Cancer Prev 2021;26:41
    https://doi.org/10.15430/JCP.2021.26.1.41
  3. Ana Paula da Fonseca Machado, Mariana da Rocha Alves, Roberto de Paula do Nascimento, Lívia Mateus Reguengo, Mario Roberto Marostica Junior. Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer. Food Research International 2022;162:111953
    https://doi.org/10.1016/j.foodres.2022.111953
  4. Jéssica Alessandra-Perini, Karina Cristina Rodrigues-Baptista, Daniel Escorsim Machado, Luiz Eurico Nasciutti, Jamila Alessandra Perini, Siyaram Pandey. Anticancer potential, molecular mechanisms and toxicity of Euterpe oleracea extract (açaí): A systematic review. PLoS ONE 2018;13:e0200101
    https://doi.org/10.1371/journal.pone.0200101
  5. Carlos Augusto Real Martinez, José Aires Pereira, Julia Soto Rizzato, Gabriele Polezi, Roberto de Paula do Nascimento, Mário Roberto Maróstica Junior. Natural Plant Products in Inflammatory Bowel Diseases. 2018.
    https://doi.org/10.1016/B978-0-323-99111-7.00016-7
  6. Bahare Salehi, Javad Sharifi-Rad, Francesca Cappellini, Željko Reiner, Debora Zorzan, Muhammad Imran, Bilge Sener, Mehtap Kilic, Mohamed El-Shazly, Nouran M. Fahmy, Eman Al-Sayed, Miquel Martorell, Chiara Tonelli, Katia Petroni, Anca Oana Docea, Daniela Calina, Alfred Maroyi. The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action. Front. Pharmacol. 2020;11
    https://doi.org/10.3389/fphar.2020.01300
  7. Roberto de Paula do Nascimento, Lívia Mateus Reguengo, Ana Paula da Fonseca Machado, Mario Roberto Marostica Junior. The preventive and therapeutic potential of native Brazilian fruits on colorectal cancer. Food Bioscience 2022;46:101539
    https://doi.org/10.1016/j.fbio.2021.101539
  8. Vinicius Ruan Neves dos Santos, Deborah Ribeiro Frazão, Railson de Oliveira Ferreira, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Deiweson Souza-Monteiro, Leonardo Oliveira Bittencourt, João Daniel Mendonça de Moura, José Messias Perdigão, Bruno José Brito Teixeira, Everton Luiz Pompeu Varela, Gabriela de Souza Balbinot, Sandro Percário, Herve Rogez, Cassiano Kuchenbecker Rösing, Fabrício Mezzomo Collares, Rafael Rodrigues Lima. Açaí (Euterpe oleracea Mart.) Attenuates Oxidative Stress and Alveolar Bone Damage in Experimental Periodontitis in Rats. Antioxidants 2022;11:1902
    https://doi.org/10.3390/antiox11101902
  9. Hyeon-Hui Ki, Ji-Hyun Lee, Hoon-Yeon Lee, Young-Mi Lee, Dae-Ki Kim. Triticum aestivumSprouts Extract Inhibits Azoymethane (AOM)/Dextran Sodium Sulfate (DSS)-Induced Colon Carcinogenesis in Mice. Nutrition and Cancer 2018;70:928
    https://doi.org/10.1080/01635581.2018.1490447
  10. Alejandra Sanín, Diana P. Navia, Johanna A. Serna-Jiménez. Functional Foods from Crops on the Northern Region of the South American Andes: The Importance of Blackberry, Yacon, Açai, Yellow Pitahaya and the Application of Its Biocompounds. International Journal of Fruit Science 2020;20:S1784
    https://doi.org/10.1080/15538362.2020.1834894
  11. Thalita Sévia Soares de Almeida Magalhães, Pollyana Cristina de Oliveira Macedo, Attilio Converti, Ádley Antonini Neves de Lima. The Use of Euterpe oleracea Mart. As a New Perspective for Disease Treatment and Prevention. Biomolecules 2020;10:813
    https://doi.org/10.3390/biom10060813
  12. Elisabete Nascimento-Gonçalves, Bruno A.L. Mendes, Rita Silva-Reis, Ana I. Faustino-Rocha, Adelina Gama, Paula A. Oliveira. Animal Models of Colorectal Cancer: From Spontaneous to Genetically Engineered Models and Their Applications. Veterinary Sciences 2021;8:59
    https://doi.org/10.3390/vetsci8040059
  13. Isabelle C. V. S. Martins, Natália A. Borges, Peter Stenvinkel, Bengt Lindholm, Hervé Rogez, Maria C. N. Pinheiro, José L. M. Nascimento, Denise Mafra. The value of the Brazilian açai fruit as a therapeutic nutritional strategy for chronic kidney disease patients. Int Urol Nephrol 2018;50:2207
    https://doi.org/10.1007/s11255-018-1912-z
  14. Karina Nascimento da Silva, Débora Salles, Andréa Cristina de Moraes Malinverni, Daniel Araki Ribeiro, Ana Paula Ribeiro Paiotti. Natural Plant Products in Inflammatory Bowel Diseases. 2018.
    https://doi.org/10.1016/B978-0-323-99111-7.00017-9
  15. Roberto de Paula do Nascimento, Ana Paula da Fonseca Machado. The preventive and therapeutic effects of anthocyanins on colorectal cancer: A comprehensive review based on up-to-date experimental studies. Food Research International 2023;170:113028
    https://doi.org/10.1016/j.foodres.2023.113028
  16. Raquel Martinez, Deborah Guimarães, Camila Berniz, Joel Abreu, Ana Rocha, Roberto Moura, Angela Resende, Anderson Teodoro. Açai (Euterpe oleracea Mart.) Seed Extract Induces Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma Cells. Foods 2018;7:178
    https://doi.org/10.3390/foods7110178
  17. Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Joo Hee Son, Jeong Eun Yu, Eun Shin, Ha-Na Lee, Do-Hee Kim, Young-Joon Surh. 17β-Estradiol strongly inhibits azoxymethane/dextran sulfate sodium-induced colorectal cancer development in Nrf2 knockout male mice. Biochemical Pharmacology 2020;182:114279
    https://doi.org/10.1016/j.bcp.2020.114279
  18. Roberto de Paula do Nascimento, Ana Paula da Fonseca Machado, Julio Galvez, Cinthia Baú Betim Cazarin, Mario Roberto Maróstica Junior. Ulcerative colitis: Gut microbiota, immunopathogenesis and application of natural products in animal models. Life Sciences 2020;258:118129
    https://doi.org/10.1016/j.lfs.2020.118129
  19. Maryam N. ALNasser, Ian R. Mellor. Neuroprotective activities of acai berries (Euterpe sp.): A review. J Herbmed Pharmacol 2022;11:166
    https://doi.org/10.34172/jhp.2022.21
  20. Marcos Antonio Custódio Neto da Silva, Jonas Henrique Costa, Taícia Pacheco-Fill, Ana Lúcia Tasca Gois Ruiz, Flávia Castello Branco Vidal, Kátia Regina Assunção Borges, Sulayne Janaina Araújo Guimarães, Ana Paula Silva de Azevedo-Santos, Kaio Eduardo Buglio, Mary Ann Foglio, Maria do Carmo Lacerda Barbosa, Maria do Desterro Soares Brandão Nascimento, João Ernesto de Carvalho. Açai (Euterpe oleracea Mart.) Seed Extract Induces ROS Production and Cell Death in MCF-7 Breast Cancer Cell Line. Molecules 2021;26:3546
    https://doi.org/10.3390/molecules26123546
  21. Jhonny Alejandro Poveda-Giraldo, Sara Piedrahita-Rodríguez, Natalia Salgado Aristizabal, Manuel Salas-Moreno, Carlos Ariel Cardona Alzate. Prefeasibility analysis of small-scale biorefineries: the annatto and açai case to improve the incomes of rural communities. Biomass Conv. Bioref. 2022
    https://doi.org/10.1007/s13399-022-03479-w
  22. Hee Jin Son, Sung Hwa Sohn, Nayoung Kim, Ha-Na Lee, Sun Min Lee, Ryoung Hee Nam, Ji Hyun Park, Chin-Hee Song, Eun Shin, Hee Young Na, Joo Sung Kim, Dong Ho Lee, Young-Joon Surh. Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development. Cancer Res Treat 2019;51:632
    https://doi.org/10.4143/crt.2018.060
  23. Sonia Sayago-Ayerdi, Diana Laura García-Martínez, Ailin Cecilia Ramírez-Castillo, Heidi Rubí Ramírez-Concepción, Manuel Viuda-Martos. Tropical Fruits and Their Co-Products as Bioactive Compounds and Their Health Effects: A Review. Foods 2021;10:1952
    https://doi.org/10.3390/foods10081952
  24. Natália A. Campos, Marcela S. B. da Cunha, Sandra F. Arruda, Birke Bartosch. Tucum-do-cerrado (Bactris setosa Mart.) modulates oxidative stress, inflammation, and apoptosis-related proteins in rats treated with azoxymethane. PLoS ONE 2018;13:e0206670
    https://doi.org/10.1371/journal.pone.0206670
  25. F.P. Silva, D.A. De Miranda, M. Carnier, P.K. Maza, V.T. Boldarine, A.B. Silva Rischiteli, F. Avila, L.P.P. Pontes, A.C.L. Hachul, N.I.P. Neto, E.B. Ribeiro, C.M. Oller do Nascimento, V.V. de Rosso, L.M. Oyama. Low dose of Juçara pulp (Euterpe edulis Mart.) minimizes the colon inflammatory milieu promoted by hypercaloric and hyperlipidic diet in mice. Journal of Functional Foods 2021;77:104343
    https://doi.org/10.1016/j.jff.2020.104343
  26. Marcos Antonio Custódio Neto da Silva, Josiane Weber Tessmann, Kátia Regina Assunção Borges, Laís Araújo Souza Wolff, Fernanda Diniz Botelho, Leandro Alegria Vieira, Jose Andres Morgado-Diaz, Tanos Celmar Costa Franca, Maria do Carmo Lacerda Barbosa, Maria do Desterro Soares Brandão Nascimento, Murilo Ramos Rocha, João Ernesto de Carvalho. Açaí (Euterpe oleracea Mart.) Seed Oil Exerts a Cytotoxic Role over Colorectal Cancer Cells: Insights of Annexin A2 Regulation and Molecular Modeling. Metabolites 2023;13:789
    https://doi.org/10.3390/metabo13070789
  27. Marcos Antonio Custódio Neto da Silva, Laís Araújo Souza Wolff, Kátia Regina Assunção Borges, André Alvares Marques Vale, Ana Paula Silva de Azevedo-Santos, Marcelo Antonio Pascoal Xavier, Maria do Carmo Lacerda Barbosa, Maria do Desterro Soares Brandão Nascimento, João Ernesto de Carvalho. Açaí (Euterpe oleracea Mart.) byproduct reduces tumor size and modulates inflammation in Ehrlich mice model. Journal of Functional Foods 2023;103:105474
    https://doi.org/10.1016/j.jff.2023.105474
  28. Sandra S. Arango-Varela, Ivan Luzardo-Ocampo, Maria E. Maldonado-Celis. Andean berry (Vaccinium meridionale Swartz) juice, in combination with Aspirin, displayed antiproliferative and pro-apoptotic mechanisms in vitro while exhibiting protective effects against AOM-induced colorectal cancer in vivo. Food Research International 2022;157:111244
    https://doi.org/10.1016/j.foodres.2022.111244
  29. Roberto de Paula do Nascimento, Gabriele Polezi, Julia Soto Rizzato, Patrícia Berilli Batista, Nathalia Medina dos Santos, Paulo Sérgio Loubet Filho, Lívia Mateus Reguengo, Joseane Morari, Stanislau Bogusz Junior, Ana Paula Ribeiro Paiotti, José Aires Pereira, Carlos Augusto Real Martinez, Lício Augusto Velloso, Cinthia Bau Betim Cazarin, Mario Roberto Marostica Junior. Brazilian berries prevent colitis induced in obese mice by reducing the clinical signs and intestinal damage. Food Bioscience 2021;44:101447
    https://doi.org/10.1016/j.fbio.2021.101447
  30. Candice Mazewski, Elvira Gonzalez de Mejia. Advances in Plant Phenolics: From Chemistry to Human Health. 2021.
    https://doi.org/10.1021/bk-2018-1286.ch019
  31. Chin-Hee Song, Nayoung Kim, Sun Min Lee, Ryoung Hee Nam, Soo In Choi, So Ra Kang, Eun Shin, Dong Ho Lee, Ha-Na Lee, Young-Joon Surh. Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice. Biochemical Pharmacology 2019;164:139
    https://doi.org/10.1016/j.bcp.2019.04.011
  32. Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang, Shizhu Jin. Dental pulp stem cells overexpressing hepatocyte growth factor facilitate the repair of DSS-induced ulcerative colitis. Stem Cell Res Ther 2021;12
    https://doi.org/10.1186/s13287-020-02098-4
  33. Vieira da Silva Martins Isabelle Christine, Christine Isabelle, Rogez Herve , Nascimento Pinheiro Maria Conceicao, Rodrigues Keuri Eleuterio, Matos Macchi Barbarella de, Reis Andrea Dias, Paiva Bruna Regis, de Brito Jessyca Sousa, da Silva Greicielle Santos, Silva Lima Abner Ariel da, Santos Pinto Luis Claudio, Martins Nascimento Jose Luiz. Effects of clarified açai (Euterpe oleracea Mart) supplementation on oxidative stress markers in hemodialysis patients: A randomized, controlled pilot study. J Food Sci Nutr The 2020:032
    https://doi.org/10.17352/jfsnt.000024
  34. Schalana Oliveira dos Reis, Tamires Conceição da Luz, Cinthia Vidal Monteiro da Silva Couto, Juliana Dalbó, Louisiane de Carvalho Nunes, Marina Carvalho Martins, Pollyanna Ibrahim Silva, Adriana Madeira Alvares da Silva, Leonardo Oliveira Trivilin. Juçara (Euterpe edulis Mart.) Supplementation Reduces Aberrant Crypt Foci and Increases SOD1 Expression in the Colorectal Mucosa of Carcinogenesis-Induced Rats. Nutrition and Cancer 2020;72:610
    https://doi.org/10.1080/01635581.2019.1649437
  35. Qianer Jiang, Suvimol Charoensiddhi, Xiaofeng Xue, Biqi Sun, Yang Liu, Hesham R. El-Seedi, Kai Wang. A review on the gastrointestinal protective effects of tropical fruit polyphenols. Critical Reviews in Food Science and Nutrition 2023;63:7197
    https://doi.org/10.1080/10408398.2022.2145456
  36. Walbert Edson Muniz Filho, Fernando Almeida-Souza, André Alvares Marques Vale, Elis Cabral Victor, Mirtes Castelo Branco Rocha, Gabriel Xavier Silva, Amanda Mara Teles, Flavia Raquel Fernandes Nascimento, Carla Junqueira Moragas-Tellis, Maria do Socorro dos Santos Chagas, Maria Dutra Behrens, Daiana de Jesus Hardoim, Noemi Nosomi Taniwaki, Josélia Alencar Lima, Ana Lucia Abreu-Silva, Rui M. Gil da Costa, Kátia da Silva Calabrese, Ana Paula Silva de Azevedo-Santos, Maria do Desterro Soares Brandão Nascimento. Antitumor Effect of Açaí (Euterpe oleracea Mart.) Seed Extract in LNCaP Cells and in the Solid Ehrlich Carcinoma Model. Cancers 2023;15:2544
    https://doi.org/10.3390/cancers15092544
  37. Suneel K. Kandagatla, Robin Tate Uhl, Tyler N. Graf, Nicholas H. Oberlies, Gregory M. Raner. Pheophorbide Derivatives Isolated From Açaí Berries (Euterpea oleracea) Activate an Antioxidant Response Element In Vitro. Natural Product Communications 2019;14:1934578X1985244
    https://doi.org/10.1177/1934578X19852443
  38. María S. Cid-Gallegos, Xariss M. Sánchez-Chino, Isela Álvarez-González, Eduardo Madrigal-Bujaidar, Verónica R. Vásquez-Garzón, Rafael Baltiérrez-Hoyos, Saúl Villa-Treviño, Gloria Dávila-Ortíz, Cristian Jiménez-Martínez. Modification of In Vitro and In Vivo Antioxidant Activity by Consumption of Cooked Chickpea in a Colon Cancer Model. Nutrients 2020;12:2572
    https://doi.org/10.3390/nu12092572
  39. Lucas Fornari Laurindo, Sandra Maria Barbalho, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Arijit Mondal, Gabrielle Bachtel, Anupam Bishayee. Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review. Nutrients 2023;15:989
    https://doi.org/10.3390/nu15040989
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