GNL Gut and Liver
  1. Jian Li, Boxun Jin, Tiezheng Wang, Wenlei Li, Zhenshun Wang, Haitao Zhang, Yunjun Song, Ning Li. Serum microRNA expression profiling identifies serum biomarkers for HCV-related hepatocellular carcinoma. CBM 2019;26:501
    https://doi.org/10.3233/CBM-181970
  2. Hiroaki Takaya, Tadashi Namisaki, Naotaka Shimozato, Kosuke Kaji, Mitsuteru Kitade, Kei Moriya, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Masanori Matsumoto, Hitoshi Yoshiji. ADAMTS13 and von Willebrand factor are useful biomarkers for sorafenib treatment efficiency in patients with hepatocellular carcinoma. WJGO 2019;11:424
    https://doi.org/10.4251/wjgo.v11.i5.424
  3. Size Wu, Xiyuan Lin. Trials in developing a nanoscale material for extravascular contrast-enhanced ultrasound targeting hepatocellular carcinoma. 2020;8:e10403
    https://doi.org/10.7717/peerj.10403
  4. Jialiang Wang, Yifan Lian, Yurong Gu, Hongbo Wang, Lin Gu, Yanlin Huang, Liang Zhou, Yuehua Huang. Synergistic effect of farnesyl transferase inhibitor lonafarnib combined with chemotherapeutic agents against the growth of hepatocellular carcinoma cells. Oncotarget 2017;8:105047
    https://doi.org/10.18632/oncotarget.22086
  5. Kelsey H Natsuhara, Li Zhang, Christopher A Carlos, Hala T Borno. Evaluating predictors of renal injury with sorafenib in hepatocellular carcinoma: A multi-ethnic cohort study. Journal of Onco-Nephrology 2021;5:89
    https://doi.org/10.1177/23993693211009238
  6. Susan L Stewart, Sandy L Kwong, Christopher L Bowlus, Tung T Nguyen, Annette E Maxwell, Roshan Bastani, Eric W Chak, Moon S Chen Jr. Racial/ethnic disparities in hepatocellular carcinoma treatment and survival in California, 1988-2012. WJG 2016;22:8584
    https://doi.org/10.3748/wjg.v22.i38.8584
  7. Jun Liu, Zhanzhong Ma, Yanming Liu, Liangyin Wu, Zhiwei Hou, Wenli Li. Screening of potential biomarkers in hepatitis C virus‑induced hepatocellular carcinoma using bioinformatic analysis. Oncol Lett 2019
    https://doi.org/10.3892/ol.2019.10578
  8. Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige. Cell death in a co-culture of hepatocellular carcinoma cells and human umbilical vascular endothelial cells in a medium lacking glucose and arginine. 2017;13:258
    https://doi.org/10.3892/ol.2016.5454
  9. Kuan-Chun Hsueh, Chia-Liang Lin, Jai-Nien Tung, Shun-Fa Yang, Yi-Hsien Hsieh. Nimbolide induced apoptosis by activating ERK-mediated inhibition of c-IAP1 expression in human hepatocellular carcinoma cells. Environmental Toxicology 2018
    https://doi.org/10.1002/tox.22576
  10. Yi-Hsiu Chung, Ching-Fang Yu, Shao-Chieh Chiu, Han Chiu, Shin-Ting Hsu, Ching-Rong Wu, Chung-Lin Yang, Ji-Hong Hong, Tzu-Chen Yen, Fang-Hsin Chen. Diffusion-weighted MRI and 18F-FDG PET correlation with immunity in early radiotherapy response in BNL hepatocellular carcinoma mouse model: timeline validation. Eur J Nucl Med Mol Imaging 2019;46:1733
    https://doi.org/10.1007/s00259-019-04318-3
  11. Mohammed Nihal Hasan, Hani Choudhry, Syed Shoeb Razvi, Said Salama Moselhy, Taha Abduallah Kumosani, Mazin A. Zamzami, Ziad Omran, Majed A. Halwani, Salim Al-Babili, Khalid Omer Abualnaja, Abdulrahman Labeed Al-Malki, Mahmoud Alhosin, Tadao Asami. Synthetic strigolactone analogues reveal anti-cancer activities on hepatocellular carcinoma cells. Bioorganic & Medicinal Chemistry Letters 2018;28:1077
    https://doi.org/10.1016/j.bmcl.2018.02.016
  12. Jaleh Varshosaz, Monireh M. Fard, Mina Mirian, Farshid Hassanzadeh. Targeted Nanoparticles for Co-delivery of 5-FU and Nitroxoline, a Cathepsin B Inhibitor, in HepG2 Cells of Hepatocellular Carcinoma. ACAMC 2020;20:346
    https://doi.org/10.2174/1871520619666190930124746
  13. Fuu-Jen Tsai, Xiang Liu, Chao-Jung Chen, Te-Mao Li, Jian-Shiun Chiou, Po-Heng Chuang, Cheng-Hang Ko, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Wen-Miin Liang, Ying-Ju Lin. Chinese herbal medicine therapy and the risk of overall mortality for patients with liver cancer who underwent surgical resection in Taiwan. Complementary Therapies in Medicine 2019;47:102213
    https://doi.org/10.1016/j.ctim.2019.102213
  14. Wei Guo, Jihan Huang, Ning Wang, Hor-Yue Tan, Fan Cheung, Feiyu Chen, Yibin Feng. Integrating Network Pharmacology and Pharmacological Evaluation for Deciphering the Action Mechanism of Herbal Formula Zuojin Pill in Suppressing Hepatocellular Carcinoma. Front. Pharmacol. 2019;10
    https://doi.org/10.3389/fphar.2019.01185
  15. Pin Li, Yuanyuan Shi, Baosheng Zhao, Wenhui Xu, Ziying Xu, Jingxuan Zhang, Zhaojuan Guo, Yucong Bi, Tieshan Wang, Yu Qin, Ting Wang. Pharmacological evaluation and mechanistic study of compound Xishu Granule in hepatocellular carcinoma. Journal of Traditional Chinese Medical Sciences 2020;7:255
    https://doi.org/10.1016/j.jtcms.2020.07.006
  16. Pau-Choo Julia Chung, Chao-Ting Li. Women in Computational Intelligence. 2020.
    https://doi.org/10.1007/978-3-030-79092-9_6
  17. San-Yuan Chen, Ying-Ray Lee, Ming-Chia Hsieh, Hany A. Omar, Yen-Ni Teng, Ching-Yen Lin, Jui-Hsiang Hung. Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways. Front. Pharmacol. 2018;9
    https://doi.org/10.3389/fphar.2018.00780
  18. Ju Hyun Ham, Jeong-Sik Yu, Jeong Min Choi, Eun-Suk Cho, Joo Hee Kim, Jae-Joon Chung. Corona enhancement can substitute enhancing capsule in the imaging diagnosis of small (≤ 3 cm) HCCs on gadoxetic acid–enhanced MRI. Eur Radiol 2021;31:8628
    https://doi.org/10.1007/s00330-021-07911-z
  19. Jeong-Yeon Cho, Sun-Hong Kwon, Eui-Kyung Lee, Jeong-Hoon Lee, Hye-Lin Kim. Cost-Effectiveness of Adjuvant Immunotherapy With Cytokine-Induced Killer Cell for Hepatocellular Carcinoma Based on a Randomized Controlled Trial and Real-World Data. Front. Oncol. 2021;11
    https://doi.org/10.3389/fonc.2021.728740
  20. Cheng-En Hsieh, Bhanu Prasad Venkatesulu, Ching-Hsin Lee, Sheng-Ping Hung, Pei-Fong Wong, Sathvik Panambur Aithala, Byung Kyu Kim, Arvind Rao, Joseph Tung-Chieh Chang, Ngan-Ming Tsang, Chun-Chieh Wang, Chung-Chi Lee, Chen-Chun Lin, Jeng-Hwei Tseng, Wen-Chi Chou, Yu-Chao Wang, Sunil Krishnan, Ji-Hong Hong. Predictors of Radiation-Induced Liver Disease in Eastern and Western Patients With Hepatocellular Carcinoma Undergoing Proton Beam Therapy. International Journal of Radiation Oncology*Biology*Physics 2019;105:73
    https://doi.org/10.1016/j.ijrobp.2019.02.032
  21. Jie Yang, Ying Li, Zuochun Yu, Yuefen Zhou, Jianfei Tu, Jian Lou, Yonghui Wang. Circular RNA Circ100084 functions as sponge of miR‑23a‑5p to regulate IGF2 expression in hepatocellular carcinoma. Mol Med Report 2020
    https://doi.org/10.3892/mmr.2020.11069
  22. Weibin Wang, Fang Wang, Qingqing Chen, Shuyi Ouyang, Yutaro Iwamoto, Xianhua Han, Lanfen Lin, Hongjie Hu, Ruofeng Tong, Yen-Wei Chen. Phase Attention Model for Prediction of Early Recurrence of Hepatocellular Carcinoma With Multi-Phase CT Images and Clinical Data. Front. Radio 2022;2
    https://doi.org/10.3389/fradi.2022.856460
  23. Diwakar Suresh, Akshatha N. Srinivas, Divya P. Kumar. Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease. Front. Oncol. 2020;10
    https://doi.org/10.3389/fonc.2020.601710
  24. Jae-Jun Shim, Chi Hyuck Oh, Jung Wook Kim, Chang Kyun Lee, Byung-Ho Kim. Liver cirrhosis stages and the incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving antiviral therapy. Scandinavian Journal of Gastroenterology 2017:1
    https://doi.org/10.1080/00365521.2017.1335773
  25. Wenzhe Si, Yang Zhao, Jiansuo Zhou, Qiang Zhang, Yuan Zhang. The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101. Experimental Cell Research 2019;379:1
    https://doi.org/10.1016/j.yexcr.2019.03.017
  26. Xiaozhang Shen, Sicong Ma, Xiaoyin Tang, Tao Wang, Xingxing Qi, Jiachang Chi, Zhi Wang, Dan Cui, Yuan Zhang, Ping Li, Bo Zhai. Clinical outcome in elderly Chinese patients with primary hepatocellular carcinoma treated with percutaneous microwave coagulation therapy (PMCT). 2018;97:e11618
    https://doi.org/10.1097/MD.0000000000011618
  27. Yuchong Peng, Weiye Leng, Shigang Duan, Ming Hong. Long noncoding RNA BLACAT1 is overexpressed in hepatocellular carcinoma and its downregulation suppressed cancer cell development through endogenously competing against hsa-miR-485-5p. Biomedicine & Pharmacotherapy 2019;116:109027
    https://doi.org/10.1016/j.biopha.2019.109027
  28. Rolf Teschke. Alcoholic steatohepatitis (ASH) and alcoholic hepatitis (AH): cascade of events, clinical aspects, and pharmacotherapy options. Expert Opinion on Pharmacotherapy 2018;19:779
    https://doi.org/10.1080/14656566.2018.1465929
  29. Yingchao Wang, Gaoxiong Wang, Xionghong Tan, Kun Ke, Bixing Zhao, Niangmei Cheng, Yuan Dang, Naishun Liao, Fei Wang, Xiaoyuan Zheng, Qin Li, Xiaolong Liu, Jingfeng Liu. MT1G serves as a tumor suppressor in hepatocellular carcinoma by interacting with p53. Oncogenesis 2019;8
    https://doi.org/10.1038/s41389-019-0176-5
  30. Fatema Abu-bakr Abdelmoez, Hala Mostafa Imam, Naglaa Kamal Idriss, Lobna Abdel Wahid, Wael Ahmed Abbas, Mohamed Abozaid Ali Abozaid, Hossam Mahmoud Abdelwahab. The Role of Hepatitis C virus and Possible Risk factors in development of Hepatocellular carcinoma: 400 Patients based study. Egypt J Intern Med 2019;31:64
    https://doi.org/10.4103/ejim.ejim_50_18
  31. Zhuolin Li, Yao Lin, Bizhen Cheng, Qiaoxin Zhang, Yingmu Cai. Identification and Analysis of Potential Key Genes Associated With Hepatocellular Carcinoma Based on Integrated Bioinformatics Methods. Front. Genet. 2021;12
    https://doi.org/10.3389/fgene.2021.571231
  32. Sung Uk Lee, Kyungmi Yang, Sung Ho Moon, Yang-Gun Suh, Gyu Sang Yoo. Patterns of Proton Beam Therapy Use in Clinical Practice between 2007 and 2019 in Korea. Cancer Res Treat 2021;53:935
    https://doi.org/10.4143/crt.2021.409
  33. An-Ting Liou, Mei-Fang Chen, Chu-Wen Yang. Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. Evidence-Based Complementary and Alternative Medicine 2017;2017:1
    https://doi.org/10.1155/2017/4063865
  34. Masatoshi Kudo, Ho Yeong Lim, Ann-Lii Cheng, Yee Chao, Thomas Yau, Sadahisa Ogasawara, Masayuki Kurosaki, Naoki Morimoto, Kazuyoshi Ohkawa, Tatsuya Yamashita, Kyung-Hun Lee, Erluo Chen, Abby B. Siegel, Baek-Yeol Ryoo. Pembrolizumab as Second-Line Therapy for Advanced Hepatocellular Carcinoma: A Subgroup Analysis of Asian Patients in the Phase 3 KEYNOTE-240 Trial. Liver Cancer 2021;10:275
    https://doi.org/10.1159/000515553
  35. Ming Xu, Lonbo Zhen, Liumei Lin, Ke Wu, Yifan Wang, Xiujun Cai. Overexpression of CSN6 promotes the epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. Clinics and Research in Hepatology and Gastroenterology 2020;44:340
    https://doi.org/10.1016/j.clinre.2019.07.012
  36. Yu Hu, Xian Zhang, Hong-Yan Zai, Wei Jiang, Liang Xiao, Qin Zhu. lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1. Molecular Therapy - Oncolytics 2020;19:308
    https://doi.org/10.1016/j.omto.2020.10.010
  37. Yinghua Zhao, Yang Li, Wei Liu, Shan Xing, Dan Wang, Jing Chen, Longqin Sun, Jinsong Mu, Wanli Liu, Baocai Xing, Wei Sun, Fuchu He. Identification of noninvasive diagnostic biomarkers for hepatocellular carcinoma by urinary proteomics. Journal of Proteomics 2020;225:103780
    https://doi.org/10.1016/j.jprot.2020.103780
  38. Shahad W. Kattan, Mohamed S. Nafie, Gamal A. Elmgeed, Walla Alelwani, Muhammad Badar, Mohamed A. Tantawy. Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway. The Journal of Steroid Biochemistry and Molecular Biology 2020;198:105604
    https://doi.org/10.1016/j.jsbmb.2020.105604
  39. Pi-Yi Chang, Chun-Chieh Huang, Chao-Hung Hung, Chih-Yung Yu, Ding-Kwo Wu, Jen-I Hwang, Po-Chin Liang, Reng-Hong Wu, Wei-Lun Tsai, Yih-Jyh Lin, Yi-Sheng Liu, Huei-Lung Liang, Rheun-Chuan Lee, Chien-Hung Chen. Multidisciplinary Taiwan Consensus Recommendations for the Use of DEBDOX-TACE in Hepatocellular Carcinoma Treatment. Liver Cancer 2018;7:312
    https://doi.org/10.1159/000487608
  40. Nan Cheng, Ju Wu, Min Yin, Jian Xu, Yadong Wang, Xi Chen, Zhequn Nie, Jiajun Yin. LncRNA CASC11 promotes cancer cell proliferation in hepatocellular carcinoma by inhibiting miRNA-188-5p. 2019;39
    https://doi.org/10.1042/BSR20190251
  41. Lingling He, Xiaohui Ye, Jiali Ma, Ping Li, Yu Jiang, Julong Hu, Junru Yang, Yuling Zhou, Xiuxia Liang, Yijun Lin, Hongshan Wei. Antiviral therapy reduces rebleeding rate in patients with hepatitis B-related cirrhosis with acute variceal bleeding after endotherapy. BMC Gastroenterol 2019;19
    https://doi.org/10.1186/s12876-019-1020-2
  42. Jae Won Chung, Jeong-Sik Yu, Jeong Min Choi, Eun-Suk Cho, Joo Hee Kim, Jae-Joon Chung. Subtraction Images From Portal Venous Phase Gadoxetic Acid–Enhanced MRI for Observing Washout and Enhancing Capsule Features in LI-RADS Version 2018. American Journal of Roentgenology 2020;214:72
    https://doi.org/10.2214/AJR.18.20797
  43. Adrian Bubie, Fabien Zoulim, Barbara Testoni, Brett Miles, Marshall Posner, Augusto Villanueva, Bojan Losic. Landscape of oncoviral genotype and co-infection via human papilloma and hepatitis B viral tumor in situ profiling. iScience 2021;24:102368
    https://doi.org/10.1016/j.isci.2021.102368
  44. Yonghao Liang, Qisheng Li, Keli Chen, Wen Ni, Zetao Zhan, Feng Ye, Yiyi Li, Yuan Fang, Fengjiao Zhang, Longhua Chen, Yi Ding. Zinc finger protein 307 functions as a tumor-suppressor and inhibits cell proliferation by inducing apoptosis in hepatocellular carcinoma. 2017;38:2229
    https://doi.org/10.3892/or.2017.5868
  45. Xinxin Sang, Meng Zhang, Quanwu Wen, Gang Shi, Liping Zhang, Caihua Ni. Preparation of Drug-Eluting Microspheres Based on Semi-Interpenetrating Polymer Network of Modified Chitosan and Poly(2-acrylamide-2-methylpropanesulfonic acid). Polym. Sci. Ser. A 2019;61:61
    https://doi.org/10.1134/S0965545X19010061
  46. Jicun Zhu, Peng Wang, Hua Ye, Jianxiang Shi, Xiao Wang, Keyan Wang, Fujiao Duan, Qian Yang, Guiying Sun, Jianying Zhang. Trend of the mortality of major liver diseases and its impact on life expectancy in China from 2006 to 2017. 2022;44:100
    https://doi.org/10.1093/pubmed/fdaa261
  47. Aysheh Alrfooh, Aditi Patel, Sandeep Laroia. Transarterial Radioembolization Agents: a Review of the Radionuclide Agents and the Carriers. Nucl Med Mol Imaging 2021;55:162
    https://doi.org/10.1007/s13139-021-00709-3
  48. A. Nonpunya, B. Sethabouppha, S. Rufini, N. Weerapreeyakul. Cratoxylum formosum ssp. pruniflorum activates the TRAIL death receptor complex and inhibits topoisomerase I. South African Journal of Botany 2018;114:150
    https://doi.org/10.1016/j.sajb.2017.11.003
  49. Nur Signa A Gumilas, Ika M Harini, Thianty Sylviningrum, Wahyu Djatmiko, Lantip Rujito. Hepatitis B as hepatocellular carcinoma (HCC) risk factor in the south region of Java, Indonesia. J. Phys.: Conf. Ser. 2019;1246:012013
    https://doi.org/10.1088/1742-6596/1246/1/012013
  50. Weidong Shi, Lanyun Feng, Shu Dong, Zhouyu Ning, Yongqiang Hua, Luming Liu, Zhen Chen, Zhiqiang Meng. Exploration of prognostic index based on immune-related genes in patients with liver hepatocellular carcinoma. 2020;40
    https://doi.org/10.1042/BSR20194240
  51. Meng Xue, Xiaona Lin, Qiu‐Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing‐Fang Li, Jun Hou, Xudong Liu, Ren Chen. Association between hepatitis B and E virus infection and hepatocellular carcinoma risk. Int. J. Cancer 2021;148:2974
    https://doi.org/10.1002/ijc.33505
  52. Ming-Hsien Chien, Yung-Chuan Ho, Shun-Fa Yang, Yi-Chieh Yang, Szu-Yu Lai, Wan-Shen Chen, Ming-Jenn Chen, Chao-Bin Yeh. Niclosamide, an oral antihelmintic drug, exhibits antimetastatic activity in hepatocellular carcinoma cells through downregulating twist-mediated CD10 expression. Environmental Toxicology 2018;33:659
    https://doi.org/10.1002/tox.22551
  53. Chong Teik Lim, George Boon Bee Goh, Huihua Li, Tony Kiat-Hon Lim, Wei Qiang Leow, Wei Keat Wan, Rafay Azhar, Wan Cheng Chow, Rajneesh Kumar. Presence of Hepatic Steatosis Does Not Increase the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Over Long Follow-Up. Microbiol�Insights 2020;13:117863612091887
    https://doi.org/10.1177/1178636120918878
  54. Maryam Salari, Anoshirvan Kazemnejad, Farid Zayeri. Clustering Asian Countries According to the Trend of liver cancer Mortality Rates: an Application of Growth Mixture Models. Iran Red Crescent Med J 2017;19
    https://doi.org/10.5812/ircmj.15107
  55. Jung Yeon Seo, Joong-Gon Shin, Byeong Ju Youn, Suhg Namgoong, Hyun Sub Cheong, Lyoung Hyo Kim, Ji On Kim, Hyoung Doo Shin, Yoon Jun Kim. A non-synonymous variant rs12614 of complement factor B associated with risk of chronic hepatitis B in a Korean population. BMC Med Genet 2020;21
    https://doi.org/10.1186/s12881-020-01177-w
  56. Rinku Dutta, Ram I. Mahato. Recent advances in hepatocellular carcinoma therapy. Pharmacology & Therapeutics 2017;173:106
    https://doi.org/10.1016/j.pharmthera.2017.02.010
  57. Tian Hu, Jincheng Li, Chuhong Zhang, Xiu lv, Sai Li, Sha He, Hanxing Yan, Yixi Tan, Mingsheng Lei, Meiling Wen, Jianhong Zuo. The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma. Genes & Diseases 2017;4:116
    https://doi.org/10.1016/j.gendis.2017.03.003
  58. . .
    https://doi.org/
  59. Chi Zhang, Zhuomiao Ye, Ziting Zhang, Jinghui Zheng, Youming Tang, Encun Hou, Zhihan Huang, Li Meng. A comprehensive evaluation of single nucleotide polymorphisms associated with hepatocellular carcinoma risk in Asian populations: A systematic review and network meta-analysis. Gene 2020;735:144365
    https://doi.org/10.1016/j.gene.2020.144365
  60. C. Bouvry, X. Palard, J. Edeline, V. Ardisson, P. Loyer, E. Garin, N. Lepareur. Transarterial Radioembolization (TARE) Agents beyond 90Y-Microspheres. BioMed Research International 2018;2018:1
    https://doi.org/10.1155/2018/1435302
  61. Roya Rezvani Habibabadi, Joseph H. Huntley, Rozita Jalilianhasanpour, David M. Yousem. Which vendor is most cited in the hepatic imaging literature?. Clinical Imaging 2021;71:39
    https://doi.org/10.1016/j.clinimag.2020.10.018
  62. Shanting Ye, Yong Ni. lncRNA SNHG9 Promotes Cell Proliferation, Migration, and Invasion in Human Hepatocellular Carcinoma Cells by Increasing GSTP1 Methylation, as Revealed by CRISPR-dCas9. Front. Mol. Biosci. 2021;8
    https://doi.org/10.3389/fmolb.2021.649976
  63. Yi Luo, Xiaojun Wang, Ling Ma, Zhihua Ma, Shen Li, Xiaoyu Fang, Xiangyu Ma. Bioinformatics analyses and biological function of lncRNA ZFPM2‑AS1 and ZFPM2 gene in hepatocellular carcinoma. Oncol Lett 2020
    https://doi.org/10.3892/ol.2020.11485
  64. Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Kosuke Kaji, Keisuke Nakanishi, Yuki Tsuji, Naotaka Shimozato, Kei Moriya, Kenichiro Seki, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Takemi Akahane, Ryuichi Noguchi, Masanori Matsumoto, Hitoshi Yoshiji. VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma. BMC Gastroenterol 2019;19
    https://doi.org/10.1186/s12876-019-1082-1
  65. Ahati Yeermaike, Peng Gu, Dengyao Liu, Tieliewuhan Nadire. LncRNA NEAT1 sponges miR-214 to promoted tumor growth in hepatocellular carcinoma. Mamm Genome 2022;33:525
    https://doi.org/10.1007/s00335-022-09952-1
  66. Hiroaki Takaya, Tadashi Namisaki, Kei Moriya, Naotaka Shimozato, Kosuke Kaji, Hiroyuki Ogawa, Koji Ishida, Yuki Tsuji, Daisuke Kaya, Hirotestu Takagi, Yukihisa Fujinaga, Norihisa Nishimura, Yasuhiko Sawada, Hideto Kawaratani, Takemi Akahane, Masanori Matsumoto, Hitoshi Yoshiji. Association between ADAMTS13 activity–VWF antigen imbalance and the therapeutic effect of HAIC in patients with hepatocellular carcinoma. WJG 2020;26:7232
    https://doi.org/10.3748/wjg.v26.i45.7232
  67. Hau V. Doan, Pishyaporn Sritangos, Roongtip Iyara, Nuannoi Chudapongse. Chrysophyllum cainito stem bark extract induces apoptosis in Human hepatocarcinoma HepG2 cells through ROS-mediated mitochondrial pathway. 2020;8:e10168
    https://doi.org/10.7717/peerj.10168
  68. Mengmeng Wang, Zhifan Xiong. The Mutation and Expression Level of LRP1B are Associated with Immune Infiltration and Prognosis in Hepatocellular Carcinoma. IJGM 2021;Volume 14:6343
    https://doi.org/10.2147/IJGM.S333390
  69. J.L Raoul, S. Faivre, J.S. Frenel, L. Rimassa. Medical oncologists must get more involved in systemic treatment. Annals of Oncology 2019;30:6
    https://doi.org/10.1093/annonc/mdy471
  70. Özden ÖZDEMİR BAŞER, Nevin ORUÇ. HEPATOSELLÜLER KARSİNOMA TANILI HASTALARDA ETİYOLOJİ VE DEMOGRAFİK ÖZELLİKLER. 2022
    https://doi.org/10.16919/bozoktip.1055425
  71. Sang Min Yoon. External Beam Radiotherapy for Hepatocellular Carcinoma: a Review of the Current Guidelines in the East and the West. J Liver Cancer 2021;21:25
    https://doi.org/10.17998/jlc.21.1.25
  72. Mandana Rastegar, Haji-Amin Marjani, Yaghoub Yazdani, Majid Shahbazi, Masoud Golalipour, Touraj Farazmandfar. Investigating Effect of Rapamycin and Metformin on Angiogenesis in Hepatocellular Carcinoma Cell Line. Adv Pharm Bull 2018;8:63
    https://doi.org/10.15171/apb.2018.008
  73. Kai‐Hsin Liao, Bor‐Sheng Ko, Liang‐Kung Chen, Fei‐Yuan Hsiao. Factors Affecting Usage Levels and Trends of Innovative Oncology Drugs Upon and After Reimbursement Under Taiwan National Health Insurance: Interrupted Time Series Analysis. Clin Transl Sci 2020;13:1288
    https://doi.org/10.1111/cts.12829
  74. Yih-Giun Cherng, Yi Cheng Chu, Vijesh Kumar Yadav, Ting-Yi Huang, Ming-Shou Hsieh, Kwai-Fong Lee, Wei-Hwa Lee, Chi-Tai Yeh, Jiann Ruey Ong. Induced Mitochondrial Alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 Pathway Facilitates Viral Hepatitis Associated Hepatocellular Carcinoma Aggressiveness and Stemness. Cancers 2021;13:2755
    https://doi.org/10.3390/cancers13112755
  75. Kristin J. Moore, Aubrey K. Hubbard, Lindsay A. Williams, Logan G. Spector. Childhood cancer incidence among specific Asian and Pacific Islander populations in the United States. Int. J. Cancer 2020;147:3339
    https://doi.org/10.1002/ijc.33153
  76. Yahiya Y. Syed. Ramucirumab: A Review in Hepatocellular Carcinoma. Drugs 2020;80:315
    https://doi.org/10.1007/s40265-020-01263-6
  77. Takeshi Makiuchi, Tomotaka Sobue. Descriptive epidemiology of biliary tract cancer incidence and geographic variation in Japan. 2022;Publish Ahead of Print
    https://doi.org/10.1097/CEJ.0000000000000758
  78. N D Yushchuk, S S Sleptsova, S I Malov, I F Bilukina, S I Semenov, L A Stepanenko, O B Ogarkov, E D Savilov, I V Malov. Assessment of external risk factors of hepatocellular cancer development and markers of genetic predisposition to its development in the ethnic group of yakut - men. Terapevticheskii arkhiv 2020;92:56
    https://doi.org/10.26442/00403660.2020.01.000505
  79. Qing-guo Xu, Sheng-xian Yuan, Qi-fei Tao, Jian Yu, Jie Cai, Yuan Yang, Xing-gang Guo, Kong-ying Lin, Jin-zhao Ma, De-shu Dai, Zhen-guang Wang, Fang-ming Gu, Ling-hao Zhao, Le-qun Li, Jing-feng Liu, Shu-han Sun, Yun-jin Zang, Hui Liu, Fu Yang, Wei-ping Zhou. A novel HBx genotype serves as a preoperative predictor and fails to activate the JAK1/STATs pathway in hepatocellular carcinoma. Journal of Hepatology 2019;70:904
    https://doi.org/10.1016/j.jhep.2019.01.007
  80. Yuan Fang. Circular RNAs as novel biomarkers with regulatory potency in human diseases. Future Science OA 2018;4:FSO314
    https://doi.org/10.4155/fsoa-2018-0036
  81. Chao-Ting Li, Hung-Wen Tsai, Tseng-Lung Yang, Jung-Chi Lin, Nan-Haw Chow, Yu Hen Hu, Kuo-Sheng Cheng, Pau-Choo Chung. Interpretable and Annotation-Efficient Learning for Medical Image Computing. 2018.
    https://doi.org/10.1007/978-3-030-61166-8_24
  82. Wasim Jafri, Muhammad Kamran. Hepatocellular Carcinoma in Asia: A Challenging Situation. 2019;9:27
    https://doi.org/10.5005/jp-journals-10018-1292
  83. Chaojie Liang, Kaitong Zhang, Hua Ge, Wei Li, Guangming Li, Jixiang Wu. Prognostic and clinicopathological value of Nanog in hepatocellular carcinoma: A meta-analysis. Clinica Chimica Acta 2018;477:24
    https://doi.org/10.1016/j.cca.2017.11.037
  84. Yeun-Yoon Kim, Jin-Young Choi, Claude B. Sirlin, Chansik An, Myeong-Jin Kim. Pitfalls and problems to be solved in the diagnostic CT/MRI Liver Imaging Reporting and Data System (LI-RADS). Eur Radiol 2019;29:1124
    https://doi.org/10.1007/s00330-018-5641-6
  85. Ji-Yeon Lee, Suk-Yong Jang, Chung Mo Nam, Eun Seok Kang. Incident Hepatocellular Carcinoma Risk in Patients Treated with a Sulfonylurea: A Nationwide, Nested, Case-Control Study. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-019-44447-1
  86. Bin Liang, Dan Zhao, Yiming Liu, Xiaopeng Guo, Hongsen Zhang, Lijie Zhang, Chuansheng Zheng. Chemoembolization of liver cancer with doxorubicin-loaded CalliSpheres microspheres: plasma pharmacokinetics, intratumoral drug concentration, and tumor necrosis in a rabbit model. Drug Deliv. and Transl. Res. 2020;10:185
    https://doi.org/10.1007/s13346-019-00672-9
  87. Yan Wang, Weijia Li, Xiangyu Chen, Ya Li, Peihao Wen, Feng Xu. MIR210HG predicts poor prognosis and functions as an oncogenic lncRNA in hepatocellular carcinoma. Biomedicine & Pharmacotherapy 2019;111:1297
    https://doi.org/10.1016/j.biopha.2018.12.134
  88. Rena Kaneko, Natsuko Nakazaki, Risa Omori, Yuichiro Yano, Masazumi Ogawa, Yuzuru Sato. Efficacy of direct-acting antiviral treatment for chronic hepatitis C: A single hospital experience. WJH 2018;10:88
    https://doi.org/10.4254/wjh.v10.i1.88
  89. Yu Feng, Liguo Liu, Jing Li, Jia Huang, Jenny Xie, Laurence Menard, Yanfen Shi, Xiaohong Zhao, Shan Xie, Wenjuan Zang, Haidong Tan, Zhiying Yang, Ling Ni. Systematic characterization of the tumor microenvironment in Chinese patients with hepatocellular carcinoma highlights intratumoral B cells as a potential immunotherapy target. Oncol Rep 2021;47
    https://doi.org/10.3892/or.2021.8249
  90. Danlei Chen, Yan Yan, Xinyi Wang, Suzhi Li, Yan Liu, Dandan Yu, Yongjing He, Ruiqing Deng, Yakun Liu, Mei Xu, Jia Luo, Hongjun Gao, Siying Wang. Chronic alcohol exposure promotes HCC stemness and metastasis through β-catenin/miR-22-3p/TET2 axis. Aging 2021;13:14433
    https://doi.org/10.18632/aging.203059
  91. 丹丹 任. Research Progress on Anti-Tumor Immune Mechanism of CD8+T Cells in HBV-Related Hepatocellular Carcinoma. ACM 2021;11:2347
    https://doi.org/10.12677/ACM.2021.115338
  92. Shichang Cui, Zhiling Qian, Yuhan Chen, Lei Li, Peng Li, Huiguo Ding. Screening of up‑ and downregulation of circRNAs in HBV‑related hepatocellular carcinoma by microarray. Oncol Lett 2017
    https://doi.org/10.3892/ol.2017.7265
  93. Nur Rahadiani, Ignasia Andhini Retnowulan, Marini Stephanie, Diah Rini Handjari, Ening Krisnuhoni. β-Catenin Expression and Its Association with Prognostic Factors in Hepatocellular Carcinoma: A Study on Alpha-fetoprotein, Histologic Grade, and Microvascular Invasion. Open Access Maced J Med Sci 2021;9:887
    https://doi.org/10.3889/oamjms.2021.6123
  94. Zhitian Shi, Dong Wei, Huamei Wu, Jiayun Ge, Xuefen Lei, Zhitang Guo, Renchao Zou, Shufeng Xiao, Tiangen Wu, Ruicheng Ma, Runyao Ai, Lin Wang. Long non‑coding RNA snaR is involved in the metastasis of liver cancer possibly through TGF‑β1. Oncol Lett 2019
    https://doi.org/10.3892/ol.2019.10258
  95. Masaru Muraoka, Shinya Maekawa, Yuichiro Suzuki, Mitsuaki Sato, Akihisa Tatsumi, Shuya Matsuda, Mika Miura, Natsuko Nakakuki, Hiroko Shindo, Fumitake Amemiya, Shinichi Takano, Mitsuharu Fukasawa, Yasuhiro Nakayama, Tatsuya Yamaguchi, Taisuke Inoue, Tadashi Sato, Atsuya Yamashita, Kohji Moriishi, Masanori Matsuda, Nobuyuki Enomoto. Cancer‐related genetic changes in multistep hepatocarcinogenesis and their correlation with imaging and histological findings. Hepatol Res 2020;50:1071
    https://doi.org/10.1111/hepr.13529
  96. Feng Zhu, Bi-Rong Wang, Zheng-Feng Zhu, Si-Qin Wang, Chu-Xing Chai, Dan Shang, Min Li. Photodynamic therapy: A next alternative treatment strategy for hepatocellular carcinoma?. WJGS 2021;13:1523
    https://doi.org/10.4240/wjgs.v13.i12.1523
  97. Liang-Cheng Chen, Wen-Yen Chiou, Hon-Yi Lin, Moon-Sing Lee, Yuan-Chen Lo, Li-Wen Huang, Chun-Ming Chang, Tsung-Hsing Hung, Chih-Wen Lin, Kuo-Chih Tseng, Dai-Wei Liu, Feng-Chun Hsu, Shih-Kai Hung. Comparing stereotactic ablative radiotherapy (SABR) versus re-trans-catheter arterial chemoembolization (re-TACE) for hepatocellular carcinoma patients who had incomplete response after initial TACE (TASABR): a randomized controlled trial. BMC Cancer 2019;19
    https://doi.org/10.1186/s12885-019-5461-3
  98. Mazhar A. Kanak, Yoshitaro Shindo, Pavithra SaiKumar, Bashoo Naziruddin. Inflammasomes: Clinical and Therapeutic Implications. 2019.
    https://doi.org/10.1007/978-3-319-89390-7_10
  99. Myat Thu Soe, Yasuaki Shibata, Myo Win Htun, Kuniko Abe, Kyaw Soe, Nay Win Than, Thann Lwin, Myat Phone Kyaw, Takehiko Koji. Immunohistochemical Mapping of Bcl9 Using Two Antibodies that Recognize Different Epitopes Is Useful to Characterize Juvenile Development of Hepatocellular Carcinoma in Myanmar. Acta Histochemica et Cytochemica 2019;52:9
    https://doi.org/10.1267/ahc.18045
  100. Mao-Chi Weng, Mei-Hui Wang, Jai-Jen Tsai, Yu-Cheng Kuo, Yu-Chang Liu, Fei-Ting Hsu, Hsin-Ell Wang. Regorafenib inhibits tumor progression through suppression of ERK/NF-κB activation in hepatocellular carcinoma bearing mice. 2018;38
    https://doi.org/10.1042/BSR20171264
  101. Shintaro Ichikawa, Utaroh Motosugi, Hiroyuki Morisaka, Kazuto Kozaka, Satoshi Goshima, Tomoaki Ichikawa. Optimal Combination of Features on Gadoxetate Disodium-enhanced MR Imaging for Non-invasive Differential Diagnosis of Hepatocellular Carcinoma: The JAMP-HCC Study. MRMS 2021;20:47
    https://doi.org/10.2463/mrms.mp.2019-0193
  102. Barathi G, Shivani Iyyappan. Utility of Immunohistochemical Expression of Ki-67 in Liver Cirrhosis and Hepatocellular Carcinoma. JDPO 2020;5:318
    https://doi.org/10.18231/j.jdpo.2020.061
  103. Ling-Ling Lu, Yong-Hui Zhang, Mei-Hua Yao, Jian-Hua Lu, Yong-Sheng Chen, Jun Xu, Jian Zhu, Hai-Zhen Chen, Jian-Guo Chen. ABO blood groups and liver cancer: prospective results from an HBsAg cohort study. BMJ Open 2021;11:e044039
    https://doi.org/10.1136/bmjopen-2020-044039
  104. Yue Han, Wei-Hua Zhi, Fei Xu, Chen-Bo Zhang, Xiao-Qian Huang, Jian-Feng Luo. Selection of first-line systemic therapies for advanced hepatocellular carcinoma: A network meta-analysis of randomized controlled trials. WJG 2021;27:2415
    https://doi.org/10.3748/wjg.v27.i19.2415
  105. Yusha Xiao, Baiyang Chen, Kang Yang, Quanxiong Wang, Pengpeng Liu, Yang Gu, Qiu Zhong, Zhisu Liu, Yueming He, Quanyan Liu. Down-regulation of MARCO associates with tumor progression in hepatocellular carcinoma. Experimental Cell Research 2019;383:111542
    https://doi.org/10.1016/j.yexcr.2019.111542
  106. Chun-Peng Zhang, Wei-Hua Li, Jia-Ren Liu, Guo-Dong Li, Hao-Peng Zhang, Jiu-Feng Wei, Hong-Sheng Chen, Jin-Lu Zhao, Yun-Feng Wang, Qiang Lv, Ming Liu, Xueliang Wu. The Effective Analysis for Blue Honeysuckle Extract in the Treatment of Hepatocellular Carcinoma. Evidence-Based Complementary and Alternative Medicine 2022;2022:1
    https://doi.org/10.1155/2022/9601020
  107. Fung-Yu Huang, Danny Ka-Ho Wong, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Man-Fung Yuen. Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma. Cell Death Discov. 2021;7
    https://doi.org/10.1038/s41420-021-00470-8
  108. Tomoki Sempokuya, Kishan P Patel, Muaataz Azawi, Jihyun Ma, Linda L Wong. Increased morbidity and mortality of hepatocellular carcinoma patients in lower cost of living areas. WJCC 2021;9:6734
    https://doi.org/10.12998/wjcc.v9.i23.6734
  109. Yinghui Wu, Kunichika Matsumoto, Ya-Mei Chen, Yu-Chi Tung, Tzu-Ying Chiu, Tomonori Hasegawa. Comparison of the cost of illness of primary liver cancer between Japan and Taiwan. Health Econ Rev 2020;10
    https://doi.org/10.1186/s13561-020-00296-7
  110. Mehmet Sayiner, Pegah Golabi, Zobair M. Younossi. Disease Burden of Hepatocellular Carcinoma: A Global Perspective. Dig Dis Sci 2019;64:910
    https://doi.org/10.1007/s10620-019-05537-2
  111. Ahmed Elmetwally Ahmed, Essam Bayoumi, Ahmed E Khayyal, Al Saied Al Refaey, Hagar Elessawy. Evaluation of diagnostic accuracy of serum calcium channel α2δ1 subunit in hepatocellular carcinoma-related cirrhosis. Egypt Liver Journal 2020;10
    https://doi.org/10.1186/s43066-020-00053-9
  112. Zhouhua Hou, Xuwen Xu, Ledu Zhou, Xiaoyu Fu, Shuhui Tao, Jiebin Zhou, Deming Tan, Shuiping Liu. The long non-coding RNA MALAT1 promotes the migration and invasion of hepatocellular carcinoma by sponging miR-204 and releasing SIRT1. Tumour Biol. 2017;39:101042831771813
    https://doi.org/10.1177/1010428317718135
  113. Pengfei Guo, Chuipu Cai, Xiaoqin Wu, Xiude Fan, Wei Huang, Jingwei Zhou, Qihui Wu, Yujie Huang, Wei Zhao, Fengxue Zhang, Qi Wang, Yongbin Zhang, Jiansong Fang. An Insight Into the Molecular Mechanism of Berberine Towards Multiple Cancer Types Through Systems Pharmacology. Front. Pharmacol. 2019;10
    https://doi.org/10.3389/fphar.2019.00857
  114. Linsong Tang, Ronggao Chen, Xiao Xu. Synthetic lethality: A promising therapeutic strategy for hepatocellular carcinoma. Cancer Letters 2020;476:120
    https://doi.org/10.1016/j.canlet.2020.02.016
  115. Wafaa Ahmed, Dina Mofed, Abdel-Rahman Zekri, Nasr El-Sayed, Mohamed Rahouma, Salwa Sabet. Antioxidant activity and apoptotic induction as mechanisms of action of Withania somnifera (Ashwagandha) against a hepatocellular carcinoma cell line. J Int Med Res 2018;46:1358
    https://doi.org/10.1177/0300060517752022
  116. Yao Huang, Jianxing Zeng, Teng Liu, Xinju Lin, Pengfei Guo, Jinhua Zeng, Weiping Zhou, Jingfeng Liu.

    Prognostic Significance of Elevated Preoperative Serum CA125 Levels After Curative Hepatectomy for Hepatocellular Carcinoma

    . OTT 2020;Volume 13:4559
    https://doi.org/10.2147/OTT.S236475
  117. Bipul Gnyawali, Antoinette Pusateri, Ashley Nickerson, Sajid Jalil, Khalid Mumtaz. Epidemiologic and socioeconomic factors impacting hepatitis B virus and related hepatocellular carcinoma. WJG 2022;28:3793
    https://doi.org/10.3748/wjg.v28.i29.3793
  118. Song Yang, Han Wang, Chundi Qin, Hongmei Sun, Yupeng Han. Up-regulation of CXCL8 expression is associated with a poor prognosis and enhances tumor cell malignant behaviors in liver cancer. 2020;40
    https://doi.org/10.1042/BSR20201169
  119. Christelle Bouvry, Valérie Ardisson, Nicolas Noiret, Etienne Garin, Nicolas Lepareur. Labeling of Hinokitiol with 90Y for Potential Radionuclide Therapy of Hepatocellular Carcinoma. Processes 2021;9:940
    https://doi.org/10.3390/pr9060940
  120. Xue-Yan Wang, Jin-Mei Huang, Xue-Ming Lu, Tim J. Harrison, Hua-Bing Liu, Hui-Hua Jia, Zhong-Liao Fang. Changing risk factors for hepatocellular carcinoma in hyperendemic regions in the era of universal hepatitis B vaccination. Cancer Epidemiology 2020;67:101775
    https://doi.org/10.1016/j.canep.2020.101775
  121. Soheil Hassanipour, Majid Mohammadzadeh, Fariborz Mansour-Ghanaei, Mohammad Fathalipour, Farahnaz Joukar, Hamid Salehiniya, Elham Abdzadeh, Ali Akbar Samadani, Hossein-Ali Nikbakht, Morteza Arab-Zozani. The Incidence of Hepatocellular Carcinoma in Iran from 1996 to 2016: a Systematic Review and Meta-analysis. J Gastrointest Canc 2019;50:193
    https://doi.org/10.1007/s12029-019-00207-y
  122. Shakir Saleem, Imran Kazmi, Aftab Ahmad, Mohammed F. Abuzinadah, Ali Samkari, Huda M. Alkrathy, Ruqaiyah Khan. Thiamin Regresses the Anticancer Efficacy of Methotrexate in the Amelioration of Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Wistar Strain Rats. Nutrition and Cancer 2020;72:170
    https://doi.org/10.1080/01635581.2019.1614199
  123. Hongwei Cheng, Xiaoming Yang, Gang Liu. Superstable homogeneous iodinated formulation technology: revolutionizing transcatheter arterial chemoembolization. Science Bulletin 2020;65:1685
    https://doi.org/10.1016/j.scib.2020.06.029
  124. In Fun Li, Jen‐Chien Huang, Jyh‐Jou Chen, Tseng En Wang, Sheng‐Shiung Huang, Shiow‐Luan Tsay. Factors related to the quality of life in liver cancer patients during treatment phase: A follow‐up study. Eur J Cancer Care 2019;28
    https://doi.org/10.1111/ecc.13146
  125. Abdulrahman L. Al-Malki, Etimad A. Huwait, Said S. Moselhy. Synthesis, Characterization and In vitro Antibacterial Activity of A Novel Strigolactones Analogues TIT3. J Pure Appl Microbiol 2020;14:2425
    https://doi.org/10.22207/JPAM.14.4.20
  126. J.-Y. Lee, G. Kim, Y.-H. Lee, B.-W. Lee, B.-S. Cha, C.M. Nam, E.S. Kang. Comparison of hepatocellular carcinoma risk between patients treated with glimepiride and gliclazide. Diabetes & Metabolism 2019;45:83
    https://doi.org/10.1016/j.diabet.2017.06.007
  127. Zhi Qu, Qi Ling, Jill Gwiasda, Xiao Xu, Harald Schrem, Jan Beneke, Alexander Kaltenborn, Christian Krauth, Heiko Mix, Jürgen Klempnauer, Nikos Emmanouilidis. Hangzhou criteria are more accurate than Milan criteria in predicting long-term survival after liver transplantation for HCC in Germany. Langenbecks Arch Surg 2018;403:643
    https://doi.org/10.1007/s00423-018-1696-8
  128. Prachi Nayak, Asha Mary George, Atul Goel. Unusual presentation of a common tumor. IJPO 2021;8:155
    https://doi.org/10.18231/j.ijpo.2021.029
  129. Yuanjun Liu, Kunlin Xie, Jiaxin Li, Zhi Wang, Yong Zeng, Hong Wu. Successful management of the hepatocellular carcinoma with inferior vena cava tumor thrombus. 2021;100:e26081
    https://doi.org/10.1097/MD.0000000000026081
  130. Kuo‑Shyang Jeng, Chi‑Juei Jeng, Wen‑Juei Jeng, I‑Shyan Sheen, Shih‑Yun Li, Chuen‑Miin Leu, Yeou‑Guang Tsay, Chiung‑Fang Chang. Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma (Review). Oncol Lett 2019
    https://doi.org/10.3892/ol.2019.10826
  131. Belaynew W Taye, Paul J Clark, Gunter Hartel, Elizabeth E Powell, Patricia C Valery. Remoteness of residence predicts tumor stage, receipt of treatment, and mortality in patients with hepatocellular carcinoma. JGH Open 2021;5:754
    https://doi.org/10.1002/jgh3.12580
  132. Yuwei Liu, Mengzhu Xue, Danyan Cao, Lihuai Qin, Ying Wang, Zehong Miao, Peng Wang, Xin Hu, Jingkang Shen, Bing Xiong. Multi-omics characterization of WNT pathway reactivation to ameliorate BET inhibitor resistance in liver cancer cells. Genomics 2021;113:1057
    https://doi.org/10.1016/j.ygeno.2021.02.017
  133. Thanate Kattipatanapong, Hideyuki Nishiofuku, Toshihiro Tanaka, Takeshi Sato, Tetsuya Masada, Shota Tatsumoto, Takeshi Matsumoto, Kimihiko Kichikawa. Improved Local Tumor Control and Survival Rates by Obtaining a 3D-Safety Margin in Superselective Transarterial Chemoembolization for Small Hepatocellular Carcinoma. Cardiovasc Intervent Radiol 2020;43:423
    https://doi.org/10.1007/s00270-019-02365-9
  134. Yuanmin Pei, Xueling Sun, Xiwei Guo, Huashan Yin, Le Wang, Fugu Tian, Hongxi Jing, Xiaobo Liang, Jun Xu, Pengcheng Shi. FGF8 promotes cell proliferation and resistance to EGFR inhibitors via upregulation of EGFR in human hepatocellular carcinoma cells. 2017;38:2205
    https://doi.org/10.3892/or.2017.5887
  135. Keungmo Yang, Pil S. Sung, Young K. You, Dong G. Kim, Jung S. Oh, Ho J. Chun, Jeong W. Jang, Si H. Bae, Jong Y. Choi, Seung K. Yoon. Pathologic complete response to chemoembolization improves survival outcomes after curative surgery for hepatocellular carcinoma: predictive factors of response. HPB 2019;21:1718
    https://doi.org/10.1016/j.hpb.2019.04.017
  136. Jin Chen, Xue Li, Qi Cheng, Deng Ning, Jie Ma, Zhi‐Ping Zhang, Xiao‐Ping Chen, Li Jiang. Retracted : Effects of cyclin D1 gene silencing on cell proliferation, cell cycle, and apoptosis of hepatocellular carcinoma cells . J of Cellular Biochemistry 2018;119:2368
    https://doi.org/10.1002/jcb.26400
  137. Yuanlong Cao, Yuanyuan Ding, Liping Zhang, Gang Shi, Xinxin Sang, Caihua Ni. Preparation of surface-modified, micrometer-sized carboxymethyl chitosan drug-loaded microspheres. J. Appl. Polym. Sci. 2018;135:45731
    https://doi.org/10.1002/app.45731
  138. Mikhail Kesler, Charles Levine, Dov Hershkovitz, Eyal Mishani, Yoram Menachem, Hedva Lerman, Yaniv Zohar, Oren Shibolet, Einat Even-Sapir. 68Ga-Labeled Prostate-Specific Membrane Antigen Is a Novel PET/CT Tracer for Imaging of Hepatocellular Carcinoma: A Prospective Pilot Study. J Nucl Med 2019;60:185
    https://doi.org/10.2967/jnumed.118.214833
  139. Yong Xie, Huan Tian, Bin Xiang, Yongjin Zhang, Jian Liu, Zhuoyan Cai, Hua Xiang. Transarterial chemoembolization plus sorafenib versus sorafenib for intermediate–advanced hepatocellular carcinoma. 2021;100:e26958
    https://doi.org/10.1097/MD.0000000000026958
  140. Ran-Xu Zhu, Alfred Sze Lok Cheng, Henry Lik Yuen Chan, Dong-Ye Yang, Wai-Kay Seto. Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis. WJG 2019;25:4673
    https://doi.org/10.3748/wjg.v25.i32.4673
  141. Jānis Vilmanis, Ieva Strēle, Arturs Ozoliņš, Edvīns Miklaševičs, Jānis Gardovskis. Epidemiology of Hepatocellular Carcinoma in Latvia from 1997 to 2017. 2022;76:246
    https://doi.org/10.2478/prolas-2022-0037
  142. Qi Zhao, Yiqiu Xu, Dandan Yuan, Junjun Yang, Ying Wang, Guorong Shen, Xuewen Huang, Nashwa El-Khazragy. Role of ssDNA as a Noninvasive Indicator for the Diagnosis and Prognosis of Hepatocellular Carcinoma: An Exploratory Study. Disease Markers 2021;2021:1
    https://doi.org/10.1155/2021/9958909
  143. Chi-Yuan Chen, Chin-Chuan Chen, Tzong-Ming Shieh, Chuen Hsueh, Shu-Huei Wang, Yann-Lii Leu, Jang-Hau Lian, Tong-Hong Wang. Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5. IJMS 2018;19:380
    https://doi.org/10.3390/ijms19020380
  144. Weibin Wang, Qingqing Chen, Yutaro Iwamoto, Panyanat Aonpong, Lanfen Lin, Hongjie Hu, Qiaowei Zhang, Yen-Wei Chen. Deep Fusion Models of Multi-Phase CT and Selected Clinical Data for Preoperative Prediction of Early Recurrence in Hepatocellular Carcinoma. IEEE Access 2020;8:139212
    https://doi.org/10.1109/ACCESS.2020.3011145
  145. Katherine Sievert, Rachel Liddle, Annie Tan, Niranjan Arachchi, Zina Valaydon, Nicole Allard. Promoting hospital and primary care collaboration for timely and effective care for chronic hepatitis B in western Melbourne. Aust. Health Rev. 2020;44:521
    https://doi.org/10.1071/AH19135
  146. Yajie Wang, Hua Sun, Zhiyan Xiao, Dan Zhang, Xiuqi Bao, Ning Wei. XWL-1-48 exerts antitumor activity via targeting topoisomerase II and enhancing degradation of Mdm2 in human hepatocellular carcinoma. Sci Rep 2017;7
    https://doi.org/10.1038/s41598-017-10577-7
  147. Masafumi Ikeda, Takuji Okusaka, Izumi Ohno, Shuichi Mitsunaga, Shunsuke Kondo, Hideki Ueno, Chigusa Morizane, Kazuto Gemmoto, Hideaki Suna, Yasunori Ushida, Junji Furuse. Phase I studies of peptide vaccine cocktails derived from GPC3, WDRPUH and NEIL3 for advanced hepatocellular carcinoma. Immunotherapy 2021;13:371
    https://doi.org/10.2217/imt-2020-0278
  148. Ryan B. Schwope, Matthew Katz, Timothy Russell, Michael J. Reiter, Christopher J. Lisanti. The many faces of cirrhosis. Abdom Radiol 2020;45:3065
    https://doi.org/10.1007/s00261-019-02095-z
  149. Ruifeng Xun, Hougen Lu, Xianwang Wang. Identification of CDC25C as a Potential Biomarker in Hepatocellular Carcinoma Using Bioinformatics Analysis. Technol Cancer Res Treat 2020;19:153303382096747
    https://doi.org/10.1177/1533033820967474
  150. Xi Liang Ling, Eun Young Han, Zheyuan Chen. Implications of Dynamic α-Fetoprotein on Outcomes Following Liver Transplant for Hepatocellular Carcinoma. JAMA Surg 2022;157:359
    https://doi.org/10.1001/jamasurg.2021.4570
  151. Ning Li, Ling Li, Yongshun Chen. The Identification of Core Gene Expression Signature in Hepatocellular Carcinoma. Oxidative Medicine and Cellular Longevity 2018;2018:1
    https://doi.org/10.1155/2018/3478305
  152. Dongdong Yang, Ping Gao, Chao Tian, Yang Sheng. Gompertz tracking of the growth trajectories of the human-liver-cancer xenograft-tumors in nude mice. Computer Methods and Programs in Biomedicine 2020;191:105412
    https://doi.org/10.1016/j.cmpb.2020.105412
  153. Martin C. S. Wong, Jason L. W. Huang, Jacob George, Junjie Huang, Colette Leung, Mohammed Eslam, Henry L. Y. Chan, Siew C. Ng. The changing epidemiology of liver diseases in the Asia–Pacific region. Nat Rev Gastroenterol Hepatol 2019;16:57
    https://doi.org/10.1038/s41575-018-0055-0
  154. Chai Hong Rim, Sunmin Park, Won Sup Yoon, In-Soo Shin, Hee Chul Park. Radiotherapy for bone metastases of hepatocellular carcinoma: a hybrid systematic review with meta-analyses. International Journal of Radiation Biology 2022:1
    https://doi.org/10.1080/09553002.2022.2094020
  155. Kruti Dalal, Priyanka Khorate, Bhavik Dalal, Rahul Chavan, Shobna Bhatia, Avinash Kale, Akash Shukla, Aruna Shankarkumar. Differentially expressed serum host proteins in hepatitis B and C viral infections. VirusDis. 2018;29:468
    https://doi.org/10.1007/s13337-018-0484-y
  156. Ian C Roberts-Thomson, Thomas Lung. Cost-effective options for the prevention and management of gastrointestinal and liver disease in the Asia-Pacific region. Journal of Gastroenterology and Hepatology 2018;33:121
    https://doi.org/10.1111/jgh.13925
  157. Wei Dai, Jia-Liang Dai, Mao-Hua Tang, Mu-Shi Ye, Shuo Fang. lncRNA-SNHG15 accelerates the development of hepatocellular carcinoma by targeting miR-490-3p/ histone deacetylase 2 axis. WJG 2019;25:5789
    https://doi.org/10.3748/wjg.v25.i38.5789
  158. Masaru Muraoka, Shinya Maekawa, Ryo Katoh, Yasuyuki Komiyama, Natsuko Nakakuki, Hitomi Takada, Shuya Matsuda, Yuichiro Suzuki, Mitsuaki Sato, Akihisa Tatsumi, Mika Miura, Fumitake Amemiya, Hiroko Shindo, Shinichi Takano, Mitsuharu Fukasawa, Kozue Yamauchi, Tatsuya Yamaguchi, Yasuhiro Nakayama, Taisuke Inoue, Nobuyuki Enomoto. Usefulness of Cell‐Free Human Telomerase Reverse Transcriptase Mutant DNA Quantification in Blood for Predicting Hepatocellular Carcinoma Treatment Efficacy. Hepatology Communications 2021;5:1927
    https://doi.org/10.1002/hep4.1762
  159. David Roy Nelson, Ala’a Al Hrout, Amnah Salem Alzahmi, Amphun Chaiboonchoe, Amr Amin, Kourosh Salehi-Ashtiani. Molecular Mechanisms behind Safranal’s Toxicity to HepG2 Cells from Dual Omics. Antioxidants 2022;11:1125
    https://doi.org/10.3390/antiox11061125
  160. Minqian Shen, Jingyi Cao, Haifei Shi. Effects of Estrogen and Estrogen Receptors on Transcriptomes of HepG2 Cells: A Preliminary Study Using RNA Sequencing. International Journal of Endocrinology 2018;2018:1
    https://doi.org/10.1155/2018/5789127
  161. Ottovon Bismark Dakurah, Cynthia Raissa Tchuem Tamandjou, Moleen Zunza, Wolfgang Preiser, Tongai Gibson Maponga. Viral hepatitis associated hepatocellular carcinoma on the African continent, the past, present, and future: a systematic review. BMC Cancer 2021;21
    https://doi.org/10.1186/s12885-021-08426-y
  162. Xu Yan, XinPei Lu. Plasma Cancer Therapy. 2021.
    https://doi.org/10.1007/978-3-030-49966-2_10
  163. Xiaomin Zhang, Fu’an Wang, Guangfeng Gu, Qingpo Wu, Nicola Silvestris. High HBV Load Weakens Predictive Effect of Serum miR-122 on Response to Sorafenib in Hepatocellular Carcinoma Patients. Journal of Oncology 2021;2021:1
    https://doi.org/10.1155/2021/9938207
  164. Zehao Tan, Wey Chyi Teoh, Kang Min Wong, Gervais Khin-Lin Wansaicheong, Kumaresan Sandrasegaran. Analysis of comparative performance of CEUS and CECT/MR LI-RADS classification: Can CEUS dichotomize LI-RADS indeterminate lesions on CT or MRI?. Clinical Imaging 2020;62:63
    https://doi.org/10.1016/j.clinimag.2020.02.002
  165. Iman O. Sherif, Laila A. Al-Mutabagani, Dina Sabry, Nehal M. Elsherbiny. Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression. IJMS 2020;21:7642
    https://doi.org/10.3390/ijms21207642
  166. Ping Huang, Yu Hua Zhang, Xiao Wei Zheng, Yu Jia Liu, Hong Zhang, Luo Fang, Yi Wen Zhang, Chang Yang, Khairul Islam, Chao Wang, Hua Naranmandura. Phenylarsine oxide (PAO) induces apoptosis in HepG2 cellsviaROS-mediated mitochondria and ER-stress dependent signaling pathways. Metallomics 2017;9:1756
    https://doi.org/10.1039/C7MT00179G
  167. Ken Min Chin, John Carson Allen, Jin Yao Teo, Juinn Huar Kam, Ek Khoon Tan, Yexin Koh, Brian K. P. Goh, Peng Chung Cheow, Prema Raj, Kah Hoe Pierce Chow, Yaw Fui Alexander Chung, London Lucien Ooi, Chung Yip Chan, Ser Yee Lee. Predictors of post-hepatectomy liver failure in patients undergoing extensive liver resections for hepatocellular carcinoma. Ann Hepatobiliary Pancreat Surg 2018;22:185
    https://doi.org/10.14701/ahbps.2018.22.3.185
  168. Sadahisa Ogasawara, Keisuke Koroki, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Takayuki Kondo, Ryo Nakagawa, Shingo Nakamoto, Ryosuke Muroyama, Tetsuhiro Chiba, Naoya Kato. Changes in therapeutic options for hepatocellular carcinoma in Asia. Liver International 2022;42:2055
    https://doi.org/10.1111/liv.15101
  169. Yuanyuan Zheng, Zheping Yu, Yougui Li, Shi Zhong, Yuqing Sun, Li Sun, Xiliang Zheng, Xingjiang Qi, Shuwen Zhang. Alcohol extracts of Chinese bayberry branch induce S‐phase arrest and apoptosis in H ep G 2 cells . Food Science & Nutrition 2022
    https://doi.org/10.1002/fsn3.3080
  170. Hai-Jian Sun, Zhi-Yuan Wu, Xiao-Wei Nie, Xin-Yu Wang, Jin-Song Bian. Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. Journal of Advanced Research 2021;27:127
    https://doi.org/10.1016/j.jare.2020.05.010
  171. Ariraman Subastri, Arumugam Suyavaran, Ezhuthupurakkal Preedia Babu, Subramaniyam Nithyananthan, Rajamani Barathidasan, Chinnasamy Thirunavukkarasu. Troxerutin with copper generates oxidative stress in cancer cells: Its possible chemotherapeutic mechanism against hepatocellular carcinoma. J Cell Physiol 2018;233:1775
    https://doi.org/10.1002/jcp.26061
  172. Rui Liu, Haiyang Zhang, Yan Zhang, Shuang Li, Xinyi Wang, Xia Wang, Cheng Wang, Bin Liu, Ke Zen, Chen-yu Zhang, Chunni Zhang, Yi Ba. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha acts as a tumor suppressor in hepatocellular carcinoma. Tumour Biol. 2017;39:101042831769503
    https://doi.org/10.1177/1010428317695031
  173. Vikas Kumar, Mahfoozur Rahman, Prashant Gahtori, Fahad Al-Abbasi, Firoz Anwar, Hyung Sik Kim. Current status and future directions of hepatocellular carcinoma-targeted nanoparticles and nanomedicine. Expert Opinion on Drug Delivery 2021;18:673
    https://doi.org/10.1080/17425247.2021.1860939
  174. Xianping Cheng, Mo Chen, Zhenyun Liu. MicroRNA-294 Promotes Cell Proliferation, Migration and Invasion in SMMC-7721 Hepatoma Carcinoma Cells by Activating the JNK/ERK Signaling Pathway. The American Journal of the Medical Sciences 2020;359:365
    https://doi.org/10.1016/j.amjms.2020.03.009
  175. Ling Li, Huijia Zhao, Binyao Chen, Kang Huang, Zhuowen Hao, Zhipeng Fan, Gongpeng Sun, Jianguo Wu, Ning Li, Qifa Ye, Jiang Yue. Noninvasive Identification of Immune-Related Biomarkers in Hepatocellular Carcinoma. Journal of Oncology 2019;2019:1
    https://doi.org/10.1155/2019/2531932
  176. Tomoko Kobayashi, Mayuko Ichimura-Shimizu, Takeshi Oya, Hirohisa Ogawa, Minoru Matsumoto, Yuki Morimoto, Satoshi Sumida, Takumi Kakimoto, Michiko Yamashita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Chunmei Cheng, Koichi Tsuneyama. Neonatal streptozotocin treatment rapidly causes different subtype of hepatocellular carcinoma without persistent hyperglycemia in 4CS mice fed on a normal diet. Pathology - Research and Practice 2021;225:153559
    https://doi.org/10.1016/j.prp.2021.153559
  177. Yung-Tsung Li, Hui-Lin Wu, Chun-Jen Liu. Molecular Mechanisms and Animal Models of HBV-Related Hepatocellular Carcinoma: With Emphasis on Metastatic Tumor Antigen 1. IJMS 2021;22:9380
    https://doi.org/10.3390/ijms22179380
  178. Vasanthakumar S, Sasikala P, Padma M, Balachandar V, Venkatesh B, Ganesan S. EpCAM as a novel therapeutic target for hepatocellular carcinoma. Journal of Oncological Sciences 2017;3:71
    https://doi.org/10.1016/j.jons.2017.04.002
  179. Baoyong Wang, Hongwei Chen, Chunfen Zhang, Tian Yang, Qiaofei Zhao, Yifan Yan, Yu Zhang, Feng Xu. Effects ofhsa_circRBM23on Hepatocellular Carcinoma Cell Viability and Migration as Produced by Regulating miR-138 Expression. Cancer Biotherapy and Radiopharmaceuticals 2018;33:194
    https://doi.org/10.1089/cbr.2017.2424
  180. Shuai Lv, Yingxia Li, Hanbing Ning, Meihui Zhang, Qiaoyu Jia, Xijuan Wang. CircRNA GFRA1 promotes hepatocellular carcinoma progression by modulating the miR-498/NAP1L3 axis. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-020-79321-y
  181. Zhao-Yan Liu, Xu-Ying Tan, Qi-Jiong Li, Gong-Cheng Liao, Ai-Ping Fang, Dao-Ming Zhang, Pei-Yan Chen, Xiao-Yan Wang, Yun Luo, Jing-An Long, Rong-Huan Zhong, Hui-Lian Zhu. Trimethylamine N-oxide, a gut microbiota-dependent metabolite of choline, is positively associated with the risk of primary liver cancer: a case-control study. Nutr Metab (Lond) 2018;15
    https://doi.org/10.1186/s12986-018-0319-2
  182. Liping Zhang, Ming Liu, Tian Qi, Haili Zhou, Caihua Ni. Preparations and properties of drug-eluting embolization microspheres based on modified gelatin. Soft Materials 2018;16:117
    https://doi.org/10.1080/1539445X.2018.1435552
  183. Filippo Pelizzaro, Romilda Cardin, Anna Sartori, Angela Imondi, Barbara Penzo, Camillo Aliberti, Alberto Ponzoni, Alessandro Vitale, Umberto Cillo, Fabio Farinati. Circulating MicroRNA-21 and MicroRNA-122 as Prognostic Biomarkers in Hepatocellular Carcinoma Patients Treated with Transarterial Chemoembolization. Biomedicines 2021;9:890
    https://doi.org/10.3390/biomedicines9080890
  184. Lianyue Guan, Qiang Luo, Na Liang, Hongyu Liu. A prognostic prediction system for hepatocellular carcinoma based on gene co‑expression network. Exp Ther Med 2019
    https://doi.org/10.3892/etm.2019.7494
  185. Abdullah Sonsuz, Oguz Kagan Bakkaloglu. Biomarkers in Medicine. 2019.
    https://doi.org/10.2174/9789815040463122010020
  186. Arnold Man Nok Chui, Thomas Chung Cheung Yau, Tan To Cheung. An overview in management of hepatocellular carcinoma in Hong Kong using the Hong Kong Liver Cancer (HKLC) staging system. GHM 2020;2:312
    https://doi.org/10.35772/ghm.2020.01062
  187. Kuo-Shyang Jeng, I-Shyan Sheen, Chuen-Miin Leu, Ping-Hui Tseng, Chiung-Fang Chang. The Role of Smoothened in Cancer. IJMS 2020;21:6863
    https://doi.org/10.3390/ijms21186863
  188. Shih‐Yung Su, Wen‐Chung Lee. Mortality trends of liver diseases from 1981 to 2016 and the projection to 2035 in Taiwan: An age‐period‐cohort analysis. Liver Int 2019;39:770
    https://doi.org/10.1111/liv.14027
  189. Ming-Yao Chen, Vijesh Kumar Yadav, Yi Cheng Chu, Jiann Ruey Ong, Ting-Yi Huang, Kwai-Fong Lee, Kuen-Haur Lee, Chi-Tai Yeh, Wei-Hwa Lee. Hydroxychloroquine (HCQ) Modulates Autophagy and Oxidative DNA Damage Stress in Hepatocellular Carcinoma to Overcome Sorafenib Resistance via TLR9/SOD1/hsa-miR-30a-5p/Beclin-1 Axis. Cancers 2021;13:3227
    https://doi.org/10.3390/cancers13133227
  190. Yanchu Li, Lu Chen, Rong Pu, Lu Zhou, Xufeng Zhou, Xianyong Li. Effects of a Matrine- and Sophoridine-Containing Herbal Compound Medicine (AH-05) on Liver Cancer. Natural Product Communications 2020;15:1934578X2093522
    https://doi.org/10.1177/1934578X20935227
  191. L. Tang, M. Kamat, A. Shukla, M. Vora, C. Kalal, S. Kottilil, S. Shah. Comparative Antiviral Efficacy of Generic Sofosbuvir versus Brand Name Sofosbuvir with Ribavirin for the Treatment of Hepatitis C. Interdisciplinary Perspectives on Infectious Diseases 2018;2018:1
    https://doi.org/10.1155/2018/9124604
  192. Liang-jie Fang, Lu-yan Chen, Jun-hui Sun, Jian-ying Zhou. Clinical Characteristics and Outcomes of Acute Lung Injury Caused by Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Retrospective Cohort Study from a Single Institution in China. Analytical Cellular Pathology 2019;2019:1
    https://doi.org/10.1155/2019/4307651
  193. Yan Miao, Ying Zhang, Lihong Yin. Trends in hepatocellular carcinoma research from 2008 to 2017: a bibliometric analysis. 2018;6:e5477
    https://doi.org/10.7717/peerj.5477
  194. Jiuwei Zhang, Yaodong Chen, Jing Lin, Ruimei Jia, Tingting An, Tianxiu Dong, Yu Zhang, Xiuhua Yang. Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma. DNA and Cell Biology 2020;39:355
    https://doi.org/10.1089/dna.2019.4990
  195. Gabriele Ricco, Daniela Cavallone, Chiara Cosma, Gian Paolo Caviglia, Filippo Oliveri, Alessandra Biasiolo, Maria Lorena Abate, Mario Plebani, Antonina Smedile, Ferruccio Bonino, Patrizia Pontisso, Maurizia Rossana Brunetto. Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers. CBM 2018;21:603
    https://doi.org/10.3233/CBM-170551
  196. Sung-Gyu Lee, Long-Bin Jeng, Faouzi Saliba, Arvinder Singh Soin, Wei-Chen Lee, Paolo De Simone, Frederik Nevens, Kyung-Suk Suh, Lutz Fischer, Dong Jin Joo, John Fung, Jae-Won Joh, Toshimi Kaido, David Grant, Matthias Meier, Barbara Rauer, Carole Sips, Shuhei Kaneko, Gary Levy. Efficacy and Safety of Everolimus With Reduced Tacrolimus in Liver Transplant Recipients: 24-month Results From the Pooled Analysis of 2 Randomized Controlled Trials. 2021;105:1564
    https://doi.org/10.1097/TP.0000000000003394
  197. Longbo Zheng, Ming Xu, Junjie Xu, Ke Wu, Qian Fang, Yuelong Liang, Senjun Zhou, Dong Cen, Lin Ji, Weili Han, Xiujun Cai. ELF3 promotes epithelial–mesenchymal transition by protecting ZEB1 from miR-141-3p-mediated silencing in hepatocellular carcinoma. Cell Death Dis 2018;9
    https://doi.org/10.1038/s41419-018-0399-y
  198. Jean-Luc Raoul, Judith Raimbourg, Sandrine Hiret, Xavier Adhoute, Hélène Senellart. Épidémiologie du carcinome hépatocellulaire : simple augmentation d’incidence ou futur drame ?. Bulletin du Cancer 2018;105:502
    https://doi.org/10.1016/j.bulcan.2018.02.003
  199. Angkana Thongkum, Chunjing Wu, Ying-Ying Li, Medhi Wangpaichitr, Panida Navasumrit, Varabhorn Parnlob, Thaniya Sricharunrat, Vajarabhongsa Bhudhisawasdi, Mathuros Ruchirawat, Niramol Savaraj. The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma. IJMS 2017;18:1175
    https://doi.org/10.3390/ijms18061175
  200. Song-Huy Nguyen-Dinh, Albert Do, Trang Ngoc Doan Pham, Doan Y Dao, Trinh Nhu Nguy, Moon S Chen Jr. High burden of hepatocellular carcinoma and viral hepatitis in Southern and Central Vietnam: Experience of a large tertiary referral center, 2010 to 2016. WJH 2018;10:116
    https://doi.org/10.4254/wjh.v10.i1.116
  201. Shenghao Wang, Muhammad Kalim, Keying Liang, Jinbiao Zhan. Polyclonal antibody production against rGPC3 and their application in diagnosis of hepatocellular carcinoma. Preparative Biochemistry & Biotechnology 2018;48:435
    https://doi.org/10.1080/10826068.2018.1452258
  202. Nasimudeen R. Jabir, Saheem Ahmad, Shams Tabrez. An insight on the association of glycation with hepatocellular carcinoma. Seminars in Cancer Biology 2018;49:56
    https://doi.org/10.1016/j.semcancer.2017.06.005
  203. Bin Yang, Feng Qian, Wenjia Li, Yang Li, Yangdong Han. Effects of general anesthesia with or without epidural block on tumor metastasis and mechanisms. Oncol Lett 2018
    https://doi.org/10.3892/ol.2018.7870
  204. Xinling Cao, Guanping Zhang, Tao Li, Chengming Zhou, Lei Bai, Jinming Zhao, Turgunjan Tursun. LINC00657 knockdown suppresses hepatocellular carcinoma progression by sponging miR-424 to regulate PD-L1 expression. Genes Genom 2020;42:1361
    https://doi.org/10.1007/s13258-020-01001-y
  205. Mei Hsuan Lee, Sang Hoon Ahn, Henry L. Y. Chan, Asad Choudhry, Rino Alvani Gani, Rosmawati Mohamed, Janus P. Ong, Akash Shukla, Chee Kiat Tan, Tawesak Tanwandee, Pham Thi Thu Thuy, Boon Leong Neo, Venus Tsang, Jin Youn, Shikha Singh. Contextual and individual factors associated with knowledge, awareness and attitude on liver diseases: A large‐scale Asian study. Journal of Viral Hepatitis 2022;29:156
    https://doi.org/10.1111/jvh.13636
  206. Xu Cao, Hening Chen, Zhiguo Li, Xiaoke Li, Xianzhao Yang, Qiushuo Jin, Yijun Liang, Jiaxin Zhang, Meiyue Zhou, Ningyi Zhang, Guang Chen, Hongbo Du, Xiaobin Zao, Yong’an Ye. Network pharmacology and in vitro experiments-based strategy to investigate the mechanisms of KangXianYiAi formula for hepatitis B virus-related hepatocellular carcinoma. Front. Pharmacol. 2022;13
    https://doi.org/10.3389/fphar.2022.985084
  207. Nicole Cheng, Nathanelle Khoo, Alexander Y. F. Chung, Brian K. P. Goh, Peng Chung Cheow, Pierce K. H. Chow, Ser Yee Lee, London L. Ooi, Prema Raj Jeyaraj, Juinn Huar Kam, Ye Xin Koh, Chung Yip Chan, Jin Yao Teo. Pre-operative Imaging Characteristics in Histology-Proven Resected Intrahepatic Cholangiocarcinoma. World J Surg 2020;44:3862
    https://doi.org/10.1007/s00268-020-05698-6
  208. Ling-Ling He, Xiao-Li Liu, Shuan Zhang, Meng-Ge Li, Xian-Bo Wang, Yu-Yong Jiang, Zhi-Yun Yang. Independent risk factors for disease recurrence after surgery in patients with hepatitis B virus-related hepatocellular carcinoma ≤3 cm in diameter. 2019;7:250
    https://doi.org/10.1093/gastro/goz009
  209. Junhong Chen, Weicong Pan, Yongjin Chen, Lijia Wen, Jihao Tu, Kai Liu. Relationship of ALDH2 rs671 and CYP2E1 rs2031920 with hepatocellular carcinoma susceptibility in East Asians: a meta-analysis. World J Surg Onc 2020;18
    https://doi.org/10.1186/s12957-020-1796-0
  210. Qian Jin, Min Cheng, Xia Xia, Yuqing Han, Jing Zhang, Pengbo Cao, Gangqiao Zhou. Down‐regulation of MYH10 driven by chromosome 17p13.1 deletion promotes hepatocellular carcinoma metastasis through activation of the EGFR pathway . J Cell Mol Med 2021;25:11142
    https://doi.org/10.1111/jcmm.17036
  211. Sarita Ratana-Amornpin, Ratha-Korn Vilaichone, Muhammad Miftahussurur, Natsuda Aumpan, Kittipong Kaewkarnjanarat, Pongjarat Nun-anan, Soonthorn Chonprasertsuk, Sith Siramolpiwat, Patommatat Bhanthumkomol, Bubpha Pornthisarn, Tomohisa Uchida, Varocha Mahachai. Clinical Features and Overall Survival of Females with Hepatocellular Carcinoma: A Retrospective Study and Review of the Literature in the Association of Southeast Asian Nations. IJWH 2021;Volume 13:717
    https://doi.org/10.2147/IJWH.S311419
  212. Omar Abdel-Rahman, Winson Y. Cheung. The Expanding Role of Systemic Therapy in the Management of Hepatocellular Carcinoma. Canadian Journal of Gastroenterology and Hepatology 2018;2018:1
    https://doi.org/10.1155/2018/4763832
  213. Hyung Soon Lee, Gi Hong Choi, Jin Sub Choi, Kwang-Hyub Han, Sang Hoon Ahn, Do Young Kim, Jun Yong Park, Seung Up Kim, Sung Hoon Kim, Dong Sup Yoon, Jae Keun Kim, Jong Won Choi, Soon Sun Kim, Hana Park. Staged partial hepatectomy versus transarterial chemoembolization for the treatment of spontaneous hepatocellular carcinoma rupture: a multicenter analysis in Korea. Ann Surg Treat Res 2019;96:275
    https://doi.org/10.4174/astr.2019.96.6.275
  214. Hye Yeon Chon, Yeon Seok Seo, Jung il Lee, Byung Seok Kim, Byoung Kuk Jang, Sang Gyune Kim, Ki Tae Suk, In Hee Kim, Jin-Woo Lee, Young Eun Chon, Moon Young Kim, Soung Won Jeong, Han Ah Lee, Sun Young Yim, Soon Ho Um, Hyun Woong Lee, Kwan Sik Lee, Jeong Eun Song, Chang Hyeong Lee, Woo Jin Chung, Jae Seok Hwang, Jeong-Ju Yoo, Young Seok Kim, Dong Joon Kim, Chang Hun Lee, Jung Hwan Yu, Yeon Jung Ha, Mi Na Kim, Joo Ho Lee, Seong Gyu Hwang, Seong Hee Kang, Soon Koo Baik, Jae Young Jang, Sang Jun Suh, Young Kul Jung, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Hyung Joon Yim, Seung Up Kim. Dynamics of liver stiffness-based risk prediction model during antiviral therapy in patients with chronic hepatitis B. 2021;33:885
    https://doi.org/10.1097/MEG.0000000000001794
  215. Hye Won Lee, Se Rim Oh, Dong Yun Kim, Yechan Jeong, Seungtaek Kim, Beom Kyung Kim, Seung Up Kim, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jun Yong Park. Daclatasvir Plus Asunaprevir for the Treatment of Patients with Hepatitis C Virus Genotype 1b Infection: Real-World Efficacy, Changes in Liver Stiffness and Fibrosis Markers, and Safety. Gut and Liver 2018;12:324
    https://doi.org/10.5009/gnl17298
  216. Fei Huang, Junying Chen, Ruilong Lan, Zeng Wang, Ruiqing Chen, Jingan Lin, Lengxi Fu. Hypoxia induced δ-Catenin to enhance mice hepatocellular carcinoma progression via Wnt signaling. Experimental Cell Research 2019;374:94
    https://doi.org/10.1016/j.yexcr.2018.11.011
  217. Mei Feng, Yisheng Pan, Ruirui Kong, Shaokun Shu. Therapy of Primary Liver Cancer. The Innovation 2020;1:100032
    https://doi.org/10.1016/j.xinn.2020.100032
  218. Ting Xiong, Zihan Li, Xuelong Huang, Kaiqiang Lu, Weiquan Xie, Zhigang Zhou, Jian Tu. TO901317 inhibits the development of hepatocellular carcinoma by LXRα/Glut1 decreasing glycometabolism. American Journal of Physiology-Gastrointestinal and Liver Physiology 2019;316:G598
    https://doi.org/10.1152/ajpgi.00061.2018
  219. Rupal Ojha, Raj Nandani, Nina Chatterjee, Vijay Kumar Prajapati. Circular RNAs. 2019.
    https://doi.org/10.1007/978-981-13-1426-1_12
  220. Yasha Li, Mengnan Liu, Jiejie Cui, Ke Yang, Li Zhao, Mengjia Gong, Yi Wang, Yun He, Tongchuan He, Yang Bi. Hepa1-6-FLuc cell line with the stable expression of firefly luciferase retains its primary properties with promising bioluminescence imaging ability. Oncol Lett 2018
    https://doi.org/10.3892/ol.2018.8132
  221. Tulay Kus, Havva Yesil Cinkir, Gokmen Aktas, Huseyin Abali. Recurrence pattern in the presence of hepatosteatosis in breast cancer: does it facilitate liver metastasis?. Future Oncology 2020;16:1257
    https://doi.org/10.2217/fon-2019-0634
  222. Jiahui He, Hang Sun, Fei Li, Hao Yang, Minggeng Lou, Shunde Wang, Chuanxin Wu. Efficacy and safety of raltitrexed‐based transcatheter arterial chemoembolization for intermediate and advanced hepatocellular carcinoma: A multicenter real‐world study. Hepatology Research 2021;51:1153
    https://doi.org/10.1111/hepr.13708
  223. Sahabjada Siddiqui, Rumana Ahmad, Mohsin Ali Khan, Shivbrat Upadhyay, Ishrat Husain, Anand Narain Srivastava. Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells. Sci Rep 2019;9
    https://doi.org/10.1038/s41598-018-36475-0
  224. Yingqi She, Qinfeng Huang, Zhen Ye, Yu Hu, Mingquan Wu, Kaihua Qin, Ailing Wei, Xin Yang, Yuyao Liu, Cuihan Zhang, Qiaobo Ye. The Therapeutic Principle of Combined Strengthening Qi and Eliminating Pathogens in Treating Middle-Advanced Primary Liver Cancer: A Systematic Review and Meta-Analysis. Front. Pharmacol. 2021;12
    https://doi.org/10.3389/fphar.2021.714287
  225. Jia-Hong Liang, Qiao-Dong Xu, Song-Gang Gu. LncRNA RSU1P2-microRNA let-7a-Testis-Expressed Protein 10 axis modulates tumorigenesis and cancer stem cell-like properties in liver cancer. Bioengineered 2022;13:4285
    https://doi.org/10.1080/21655979.2022.2031394
  226. V.H.F. Lee, J. Seong, S.M. Yoon, T.C.L. Wong, B. Wang, J.L. Zhang, C.L. Chiang, P.P.Y. Ho, L.A. Dawson. Contrasting Some Differences in Managing Advanced Unresectable Hepatocellular Carcinoma Between the East and the West. Clinical Oncology 2019;31:560
    https://doi.org/10.1016/j.clon.2019.06.002
  227. Mohammed Y. Alhassani, Samir F. Zohny, Ryan A. Sheikh, Mohammed A. Hassan, Abdulaziz A. Kalantan, Salman Hosawi, Mahmoud Alhosin. Thymoquinone exerts anti-tumor activities on human hepatocellular carcinoma cells: role of angiogenesis-related genes VCAN, Grb2 and EZH2. Eur. J. Cell Sci. 2019:10
    https://doi.org/10.34154/2019-EJCS-0101-10-16/euraass
  228. Bin Li, Cong Yan, Jiamin Zhu, Xiaobing Chen, Qihan Fu, Hangyu Zhang, Zhou Tong, Lulu Liu, Yi Zheng, Peng Zhao, Weiqin Jiang, Weijia Fang. Anti–PD-1/PD-L1 Blockade Immunotherapy Employed in Treating Hepatitis B Virus Infection–Related Advanced Hepatocellular Carcinoma: A Literature Review. Front. Immunol. 2020;11
    https://doi.org/10.3389/fimmu.2020.01037
  229. Bei Wang, Tan-Yang Zhou, Chun-Hui Nie, Da-Long Wan, Shu-Sen Zheng. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer. Biochemical and Biophysical Research Communications 2018;499:156
    https://doi.org/10.1016/j.bbrc.2018.03.091
  230. Jun Cao, Dao-yuan Tu, Jie Zhou, Guo-qing Jiang, Sheng-jie Jin, Bing-bing Su, Hao Tang, Yu-hong Tang, Ao-qing Wang, Qian Wang, Ren-jie Liu, Chi Zhang, Dou-sheng Bai. Comprehensive analysis of the clinical significance, immune infiltration, and biological role of MARCH ligases in HCC. Front. Immunol. 2022;13
    https://doi.org/10.3389/fimmu.2022.997265
  231. Junwei Wei, Luyuan Ma, Wenpeng Liu, Yadong Wang, Chuan Shen, Xin Zhao, Caiyan Zhao. Identification of the molecular targets and mechanisms of compound mylabris capsules for hepatocellular carcinoma treatment through network pharmacology and bioinformatics analysis. Journal of Ethnopharmacology 2021;276:114174
    https://doi.org/10.1016/j.jep.2021.114174
  232. Qin Shi, Yongning Lu, Songjiang Huang, Chen Zhou, Chongtu Yang, Jiacheng Liu, Jinqiang Ma, Bin Xiong. Apatinib-loaded CalliSpheres Beads for embolization in a rabbit VX2 liver tumor: characterization in vitro, pharmacokinetics and tumor response in vivo. Drug Delivery 2020;27:1301
    https://doi.org/10.1080/10717544.2020.1818881
  233. Zhu Junna, Chen Gongde, Xu Jinying, Zhou Xiu. Serum AFU, 5’-NT and AFP as biomarkers for primary hepatocellular carcinoma diagnosis. 2017;12:354
    https://doi.org/10.1515/med-2017-0051
  234. Mai Hong Son, Le Ngoc Ha, Mai Hong Bang, Sungwoo Bae, Dinh Truong Giang, Nguyen Tien Thinh, Jin Chul Paeng. Diagnostic and prognostic value of 99mTc-MAA SPECT/CT for treatment planning of 90Y-resin microsphere radioembolization for hepatocellular carcinoma: comparison with planar image. Sci Rep 2021;11
    https://doi.org/10.1038/s41598-021-82887-w
  235. Bingling Dai, Yujiao Ma, Tianfeng Yang, Mengying Fan, Runze Yu, Qi Su, Hongying Wang, Feng Liu, Changhua Yang, Yanmin Zhang. Synergistic effect of berberine and HMQ1611 impairs cell proliferation and migration by regulating Wnt signaling pathway in hepatocellular carcinoma. Phytotherapy Research 2019;33:745
    https://doi.org/10.1002/ptr.6267
  236. Ya-Li Tian, Jing-Jing Ji, Lu-Ning Chen, Xin-Long Cui, Shi-Teng Liu, Liang Mao, Yu-Dong Qiu, Bing-Bing Li. Risk factors for long-term prognosis of hepatocellular carcinoma patients after anatomic hepatectomy. WJCC 2020;8:713
    https://doi.org/10.12998/wjcc.v8.i4.713
  237. Chung‐Feng Huang, Tyng‐Yuan Jang, Dae Won Jun, Sang Bong Ahn, Jihyun An, Masaru Enomoto, Hirokazu Takahashi, Eiichi Ogawa, Eileen Yoon, Soung Won Jeong, Jae‐Jun Shim, Jae Yoon Jeong, Sung Eun Kim, Hyunwoo Oh, Hyoung Su Kim, Yong Kyun Cho, Ritsuzo Kozuka, Kaori Inoue, Ka Shing Cheung, Lung Yi Mak, Jee‐Fu Huang, Chia‐Yen Dai, Man‐Fung Yuen, Mindie H. Nguyen, Ming‐Lung Yu. On‐treatment gamma‐glutamyl transferase predicts the development of hepatocellular carcinoma in chronic hepatitis B patients. Liver International 2022;42:59
    https://doi.org/10.1111/liv.15085
  238. K. Dalal, B. Dalal, S. Bhatia, A. Shukla, A. Shankarkumar. Analysis of serum Haptoglobin using glycoproteomics and lectin immunoassay in liver diseases in Hepatitis B virus infection. Clinica Chimica Acta 2019;495:309
    https://doi.org/10.1016/j.cca.2019.04.072
  239. Emma B. Holliday, Randa Tao, Zachary Brownlee, Prajnan Das, Sunil Krishnan, Cullen Taniguchi, Bruce D. Minsky, Joseph M. Herman, Ahmed Kaseb, Kanwal Raghav, Claudius Conrad, Jean-Nicholas Vauthey, Thomas A. Aloia, Yun Shin Chun, Christopher H. Crane, Eugene J. Koay. Definitive radiation therapy for hepatocellular carcinoma with portal vein tumor thrombus. Clinical and Translational Radiation Oncology 2017;4:39
    https://doi.org/10.1016/j.ctro.2017.04.003
  240. Chia-Wei Liang, Hsuan-Chia Yang, Md Mohaimenul Islam, Phung Anh Alex Nguyen, Yi-Ting Feng, Ze Yu Hou, Chih-Wei Huang, Tahmina Nasrin Poly, Yu-Chuan Jack Li. Predicting Hepatocellular Carcinoma With Minimal Features From Electronic Health Records: Development of a Deep Learning Model. JMIR Cancer 2021;7:e19812
    https://doi.org/10.2196/19812
  241. Hua Xiang, Lin Long, Yuanhui Yao, Zhiyong Fang, Zhiming Zhang, Yongjin Zhang. CalliSpheres Drug-Eluting Bead Transcatheter Arterial Chemoembolization Presents With Better Efficacy and Equal Safety Compared to Conventional TACE in Treating Patients With Hepatocellular Carcinoma. Technol Cancer Res Treat 2019;18:153303381983075
    https://doi.org/10.1177/1533033819830751
  242. Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Naotaka Shimozato, Kosuke Kaji, Yuki Tsuji, Keisuke Nakanishi, Ryuichi Noguchi, Yukihisa Fujinaga, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Kei Moriya, Takemi Akahane, Hitoshi Yoshiji. Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients. WJGO 2019;11:887
    https://doi.org/10.4251/wjgo.v11.i10.887
  243. Yu-Jen Wu, Wen-Chi Wei, Guo-Fong Dai, Jui-Hsin Su, Yu-Hwei Tseng, Tsung-Chang Tsai. Exploring the Mechanism of Flaccidoxide-13-Acetate in Suppressing Cell Metastasis of Hepatocellular Carcinoma. Marine Drugs 2020;18:314
    https://doi.org/10.3390/md18060314
  244. Shintaro Ichikawa. Medical Imaging Contrast Agents: A Clinical Manual. 2020.
    https://doi.org/10.1007/978-3-030-79256-5_12
  245. Stephannie Shih, Yen-Tsung Huang, Hwai-I Yang. A multiple mediator analysis approach to quantify the effects of the ADH1B and ALDH2 genes on hepatocellular carcinoma risk. Genet. Epidemiol. 2018;42:394
    https://doi.org/10.1002/gepi.22120
  246. Yao Huang, Jianxing Zeng, Teng Liu, Qingyi Xu, Xianglin Song, Jinhua Zeng.

    DNAM1 and 2B4 Costimulatory Domains Enhance the Cytotoxicity of Anti-GPC3 Chimeric Antigen Receptor-Modified Natural Killer Cells Against Hepatocellular Cancer Cells in vitro

    . CMAR 2020;Volume 12:3247
    https://doi.org/10.2147/CMAR.S253565
  247. Aisyah Rahimi, Azira Khalil, Amir Faisal, Khin Wee Lai. CT-MRI Dual Information Registration for the Diagnosis of Liver Cancer: A Pilot Study Using Point-based Registration. CMIR 2022;18:61
    https://doi.org/10.2174/1573405617666210825155659
  248. Nayantara Orekondy, Sheila Eswaran. Misconceptions Surrounding Hepatocellular Carcinoma. Clinical Liver Disease 2018;12:154
    https://doi.org/10.1002/cld.752
  249. Xiaopu Sang, Fenfang Wu, Di Wu, Shan Lin, Jingyi Li, Nan Zhao, Xiaoni Chen, Anlong Xu. Human Hepatic Cancer Stem Cells (HCSCs) Markers Correlated With Immune Infiltrates Reveal Prognostic Significance of Hepatocellular Carcinoma. Front. Genet. 2020;11
    https://doi.org/10.3389/fgene.2020.00112
  250. Chun-Yi Lin, Chiung-Wei Liao, Lu-Yen Chu, Kuo-Yang Yen, Long-Bin Jeng, Cheng-Nan Hsu, Cheng-Li Lin, Chia-Hung Kao. Predictive Value of 18F-FDG PET/CT for Vascular Invasion in Patients With Hepatocellular Carcinoma Before Liver Transplantation. 2017;42:e183
    https://doi.org/10.1097/RLU.0000000000001545
  251. Ran-Xu Zhu, Alfred Sze Lok Cheng, Henry Lik Yuen Chan, Dong-Ye Yang, Wai-Kay Seto. Growth arrest-specific gene 2 suppresses hepatocarcinogenesis by intervention of cell cycle and p53-dependent apoptosis. WJG 2019;25:4715
    https://doi.org/10.3748/wjg.v25.i32.4715
  252. Wei Zhang, Yifei Tan, Li Jiang, Lunan Yan, Jiayin Yang, Bo Li, Tianfu Wen, Hong Wu, WenTao Wang, Mingqing Xu. Prognostic nomogram for patients with non-B non-C hepatocellular carcinoma after curative liver resection. International Journal of Surgery 2017;44:160
    https://doi.org/10.1016/j.ijsu.2017.06.041
  253. Yu Xiong, Jing Lu, Qinliang Fang, Yuyan Lu, Chengrong Xie, Huita Wu, Zhenyu Yin. UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells. 2019;39
    https://doi.org/10.1042/BSR20182384
  254. Phimpha Paboriboune, Thomas Vial, François Chassagne, Philavanh Sitbounlang, Sengaloun Soundala, Stéphane Bertani, Davone Sengmanothong, Francois-Xavier Babin, Nicolas Steenkeste, Paul Dény, Pascal Pineau, Eric Deharo. A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos. International Journal of Hepatology 2018;2018:1
    https://doi.org/10.1155/2018/9462475
  255. Ruoh-Yun Gau, Ming-Chin Yu, Hsin-I Tsai, Cheng-Han Lee, Tony Kuo, Kuan-Chieh Lee, Wei-Chen Lee, Kun-Ming Chan, Chien-Chih Chiu, Chao-Wei Lee. Laparoscopic Liver Resection Should Be a Standard Procedure for Hepatocellular Carcinoma with Low or Intermediate Difficulty. JPM 2021;11:266
    https://doi.org/10.3390/jpm11040266
  256. Tomohiro Matsuda, Young-Joo Won, RuRu Chun-ju Chiang, Jiwon Lim, Kumiko Saika, Keisuke Fukui, Wen-Chung Lee, Laura Botta, Alice Bernasconi, Annalisa Trama. Rare cancers are not rare in Asia as well: The rare cancer burden in East Asia. Cancer Epidemiology 2020;67:101702
    https://doi.org/10.1016/j.canep.2020.101702
  257. Xin Hui Chew, Rehena Sultana, Eshani N. Mathew, David Chee Eng Ng, Richard H.G. Lo, Han Chong Toh, David Tai, Su Pin Choo, Brian Kim Poh Goh, Sean Xuexian Yan, Kelvin Siu Hoong Loke, Sue Ping Thang, Apoorva Gogna, Nanda Karaddi Venkatanarasimha, Aaron K.T. Tong, Fiona N.N. Moe, Jacelyn S.S. Chua, Reiko W.T. Ang, Aldwin D. Ong, Ashley W.Y. Ng, Marjorie T.Q. Hoang, Chow Wei Too, Choon Hua Thng, Wan Ying Chan, Wanyi Kee, Jaclyn H. M. Chan, Farah Irani, Sum Leong, Kiat Hon Lim, Michael L.C. Wang, Pierce K.H. Chow. Real-World Data on Clinical Outcomes of Patients with Liver Cancer: A Prospective Validation of the National Cancer Centre Singapore Consensus Guidelines for the Management of Hepatocellular Carcinoma. Liver Cancer 2021;10:224
    https://doi.org/10.1159/000514400
  258. Yiwen Qiu, Tao Wang, Xianwei Yang, Shu Shen, Yi Yang, Wentao Wang. Development and Validation of Artificial Neural Networks for Survival Prediction Model for Patients with Spontaneous Hepatocellular Carcinoma Rupture After Transcatheter Arterial Embolization. CMAR 2021;Volume 13:7463
    https://doi.org/10.2147/CMAR.S328307
  259. Bingfeng Zuo, Yang Zhang, Kangjie Zhao, Li Wu, Han Qi, Rong Yang, Xianjun Gao, Mengyuan Geng, Yingjie Wu, Renwei Jing, Qibing Zhou, Yiqi Seow, HaiFang Yin. Universal immunotherapeutic strategy for hepatocellular carcinoma with exosome vaccines that engage adaptive and innate immune responses. J Hematol Oncol 2022;15
    https://doi.org/10.1186/s13045-022-01266-8
  260. Balaji Musunuri, Shiran Shetty, Ganesh Bhat, Karthik Udupa, Ananth Pai. Profile of patients with hepatocellular carcinoma: An experience from a tertiary care center in India. Indian J Gastroenterol 2022;41:127
    https://doi.org/10.1007/s12664-021-01209-0
  261. Fang Wang, Thomas Bank, Gregory Malnassy, Maribel Arteaga, Na Shang, Annika Dalheim, Xianzhong Ding, Scott J. Cotler, Mitchell F. Denning, Michael I. Nishimura, Peter Breslin, Wei Qiu. Inhibition of insulin‐like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival. Hepatology Communications 2018;2:732
    https://doi.org/10.1002/hep4.1181
  262. Myo Win Htun, Yasuaki Shibata, Kyaw Soe, Takehiko Koji. Nuclear Expression of Pygo2 Correlates with Poorly Differentiated State Involving c-Myc, PCNA and Bcl9 in Myanmar Hepatocellular Carcinoma. Acta Histochem. Cytochem. 2021;54:195
    https://doi.org/10.1267/ahc.21-00090
  263. . Diagnosis of Hepatocellular Carcinoma with Gadoxetic Acid-Enhanced MRI: 2016 Consensus Recommendations of the Korean Society of Abdominal Radiology. Korean J Radiol 2017;18:427
    https://doi.org/10.3348/kjr.2017.18.3.427
  264. Christos Damaskos, Nikolaos Garmpis, Dimitrios Dimitroulis, Anna Garmpi, Evangelos Diamantis, Panagiotis Sarantis, Vasiliki E. Georgakopoulou, Alexandros Patsouras, Markos Despotidis, Dionysios Prevezanos, Athanasios Syllaios, Georgios Marinos, Evangelos Koustas, Christos Vallilas, Efstathios A. Antoniou, Konstantinos Kontzoglou, Spyridon Savvanis, Gregory Kouraklis. The Role of SNHG15 in the Pathogenesis of Hepatocellular Carcinoma. JPM 2022;12:753
    https://doi.org/10.3390/jpm12050753
  265. Nuozhou Wang, Shanshan Wang, Ming-Yue Li, Bao-guang Hu, Li-ping Liu, Sheng-li Yang, Shucai Yang, Zhongqin Gong, Paul B. S. Lai, George G. Chen. Cancer stem cells in hepatocellular carcinoma: an overview and promising therapeutic strategies. Ther Adv Med Oncol 2018;10:175883591881628
    https://doi.org/10.1177/1758835918816287
  266. Jóice Teixeira de Bitencorte, Tássia Flores Rech, Vagner Ricardo Lunge, Deivid Cruz dos Santos, Mário Reis Álvares-da-Silva, Daniel Simon. Association of interferon lambda-4 rs12979860 polymorphism with hepatocellular carcinoma in patients with chronic hepatitis C infection. WJH 2021;13:109
    https://doi.org/10.4254/wjh.v13.i1.109
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