Gut and Liver 2009; 3(1): 26-30 https://doi.org/10.5009/gnl.2009.3.1.26 Plasma 5-Hydroxytryptamine Concentration and Its Correlation with Psychopathology in Patients with Irritable Bowel Syndrome
Author Information
Seon-Young Park*, Min-Ho Park, Kyoung-Won Yoon*, Sung-Bum Cho*, Wan-Sik Lee*, Chang-Hwan Park*, Hyun-Soo Kim*, Sung-Kyu Choi*, and Jong-Sun Rew*
*Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Philip Medical Center, Seongnam, Korea

Jong-Sun Rew
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

Abstract
Background/Aims: Irritable bowel syndrome (IBS) is a biopsychosocial disorder. 5-Hydroxytryptamine (5-HT) plays a crucial role in the control of gastrointestinal motility, sensation, and secretion. This study investigated changes in platelet-depleted plasma 5-HT and their correlation with psychopathology in IBS patients and healthy subjects. Methods: This study involved 21 subjects with IBS and 13 healthy subjects. Fasting and 1-hr postprandial plasma 5-HT concentrations were measured. The SCL-90R symptom checklist was used for the assessment of current psychological symptoms. Results: Fasting and postprandial plasma 5-HT concentrations were significantly higher in IBS patients (15.11±13.51 ng/mL and 16.31±14.21 ng/mL, respectively) than in healthy subjects (5.55±4.14 ng/mL and 6.25±4.82 ng/mL, respectively; p<0.05). There were no significant changes between fasting and 1-hr postprandial 5-HT concentration in IBS subtypes and healthy subjects. Scores on all SCL-90R subscales except for the interpersonal-sensitivity subscale were significantly higher in IBS patients than in healthy subjects. No correlation was found between SCL-90R items and platelet-depleted plasma 5-HT concentration. Conclusions: 5-HT might play a critical role in IBS, and psychopathological factors are correlated with IBS. (Gut and Liver 2009;3:26-30)
Keywords: Irritable bowel syndrome; 5-hydroxytryptamine; Psychopathology
Abstract
Background/Aims: Irritable bowel syndrome (IBS) is a biopsychosocial disorder. 5-Hydroxytryptamine (5-HT) plays a crucial role in the control of gastrointestinal motility, sensation, and secretion. This study investigated changes in platelet-depleted plasma 5-HT and their correlation with psychopathology in IBS patients and healthy subjects. Methods: This study involved 21 subjects with IBS and 13 healthy subjects. Fasting and 1-hr postprandial plasma 5-HT concentrations were measured. The SCL-90R symptom checklist was used for the assessment of current psychological symptoms. Results: Fasting and postprandial plasma 5-HT concentrations were significantly higher in IBS patients (15.11±13.51 ng/mL and 16.31±14.21 ng/mL, respectively) than in healthy subjects (5.55±4.14 ng/mL and 6.25±4.82 ng/mL, respectively; p<0.05). There were no significant changes between fasting and 1-hr postprandial 5-HT concentration in IBS subtypes and healthy subjects. Scores on all SCL-90R subscales except for the interpersonal-sensitivity subscale were significantly higher in IBS patients than in healthy subjects. No correlation was found between SCL-90R items and platelet-depleted plasma 5-HT concentration. Conclusions: 5-HT might play a critical role in IBS, and psychopathological factors are correlated with IBS. (Gut and Liver 2009;3:26-30)
Keywords: Irritable bowel syndrome; 5-hydroxytryptamine; Psychopathology
Search for
Services
Archives