Gut and Liver 2008; 2(3): 174-179 https://doi.org/10.5009/gnl.2008.2.3.174 Usefulness of Autofluorescence Imaging for Estimating the Extent of Gastric Neoplastic Lesions: A Prospective Multicenter Study
Author Information
Jun Haeng Lee*, Joo Yong Cho, Myung Gyu Choi, Joo Sung Kim§, Kee Don Choi, Yong Chan Lee, Jae Young Jang#, Hoon Jai Chun**, and Sang Yong Seol††
*Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, §Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Department of Internal Medicine, Yonsei University College of Medicine, #Department of Internal Medicine, Kyung Hee University College of Medicine, **Department of Internal Medicine, Korea University College of Medicine, Seoul, and ††Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea

Myung Gyu Choi
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

Abstract
Background/Aims: The aim of this study was to determine whether the margin of early to be detected gastric cancer (EGC) and gastric adenoma is easier to be detected with autofluorescence imaging (AFI) than with white-light endoscopy (WLE). Methods: A total of 102 lesions (48 EGCs and 54 gastric adenomas) found in 98 patients were removed endoscopically or surgically. The measured length of each pathology specimen was compared with the lengths estimated using WLE, AFI, and chromoendoscopy. Results: The lesions could be discriminated from surrounding mucosa by AFI in 86 cases (84.3%). The detection rates were similar for elevated lesions (85.1%) and flat/depressed lesions (82.9%, p=0.770). In terms of histology, the detection rate was slightly higher for adenomas (90.7%) than for cancer (77.1%, p=0.058). The estimated length was shorter than the pathologic length in 31.4% of cases when using WLE and 22.1% of cases when using AFI (p=0.168). The resection range was larger for EMR than for AFI in 24 of 80 cases (30.0%). Conclusions: WLE tends to underestimate the size of EGCs, whereas AFI tends to overestimate their size. (Gut and Liver 2008; 2:174-179)
Keywords: Fluorescence; Imaging; Gastric cancer; Adenoma; Resection
Abstract
Background/Aims: The aim of this study was to determine whether the margin of early to be detected gastric cancer (EGC) and gastric adenoma is easier to be detected with autofluorescence imaging (AFI) than with white-light endoscopy (WLE). Methods: A total of 102 lesions (48 EGCs and 54 gastric adenomas) found in 98 patients were removed endoscopically or surgically. The measured length of each pathology specimen was compared with the lengths estimated using WLE, AFI, and chromoendoscopy. Results: The lesions could be discriminated from surrounding mucosa by AFI in 86 cases (84.3%). The detection rates were similar for elevated lesions (85.1%) and flat/depressed lesions (82.9%, p=0.770). In terms of histology, the detection rate was slightly higher for adenomas (90.7%) than for cancer (77.1%, p=0.058). The estimated length was shorter than the pathologic length in 31.4% of cases when using WLE and 22.1% of cases when using AFI (p=0.168). The resection range was larger for EMR than for AFI in 24 of 80 cases (30.0%). Conclusions: WLE tends to underestimate the size of EGCs, whereas AFI tends to overestimate their size. (Gut and Liver 2008; 2:174-179)
Keywords: Fluorescence; Imaging; Gastric cancer; Adenoma; Resection
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