Gut Liver 2011; 5(3): 395-396 Hepatitis A in Developed Country, the Result Should Interpret Carefully
Author Information
Seyed-Moayed Alavian*

Baqiyatallah Research Center for Gastroenterology and Liver Disease, Tehran, Iran.

Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.

Correspondence to: Seyed-Moayed Alavian. Baqiyatallah Research Center for Gastroenterology and Liver Disease, Vanaq Square, Mola Sadra St., P.O. Box 14155-3651, Tehran, Iran. Tel: +98-2188945186, Fax: +98-2188945188,
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Dear Editor,

I read with interest the published article by Chung et al.1 recently in your journal. Hepatitis A virus (HAV) infection continues to be a major health problem worldwide. Prevalence of HAV infection differs greatly in various parts of the world according to the geographic area, sanitary conditions and socioeconomic levels.2 As the authors presented the prevalence rate for anti-HAV Ab increased significantly, studies in various communities have shown that HAV prevalence rises with age.3 It will emphasize the need anti HAV vaccine during childhood in Korea especially when the symptomatic HAV infections have remarkably reported in Korea been increased during recent years.4 But there are some points that can help the readers for better understanding the issue. The living place of study group was urban and it may under-estimate the real prevalence of anti-HAV Ab in general population in Korea. In changing the developing countries to developed countries, the improvement in health status in not uniform and there are heterogeneity in distribution in every country.5 These limitation prevent for final conclusion regarding all of country in Korea, however the result is very important for health policy makers for any decision in future.

  1. Chung, GE, Yim, JY, Kim, D, et al. Seroprevalence of hepatitis a and associated socioeconomic factors in young healthy Korean adults. Gut Liver, 2011;5;88-92.
  2. Alavian, SM. Hepatitis A. Aust Fam Physician, 2011;40;185.
  3. Sofian, M, Aghakhani, A, Farazi, AA, et al. Seroepidemiology of hepatitis A virus in children of different age groups in Tehran, Iran: implications for health policy. Travel Med Infect Dis, 2010;8;176-179.
  4. Lee, D, Cho, YA, Park, Y, et al. Hepatitis a in Korea: epidemiological shift and call for vaccine strategy. Intervirology, 2008;51;70-74.
  5. Saberifiroozi, M. Hepatitis A virus infection: Is it an important hazard to public health?. Hepat Mon, 2011;11;235-237.
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