Gut and Liver 2011; 5(1): 88-92 https://doi.org/10.5009/gnl.2011.5.1.88 Seroprevalence of Hepatitis A and Associated Socioeconomic Factors in Young Healthy Korean Adults
Author Information
Goh Eun Chung, Jeong Yoon Yim, Donghee Kim, Seon Hee Lim, Min Jung Park, Young Sun Kim, Sun Young Yang, Jong In Yang, and Sang-Heon Cho
Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea

Jeong Yoon Yim
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

Abstract
Background/Aims: An epidemiologic shift of hepatitis A virus (HAV) seroprevalence is expected due to an improvement in socioeconomic status in young adults in Korea. We investigated the age-specific seroprevalence and socioeconomic factors associated with HAV seropositivity in young, healthy Korean adults. Methods: Between March 2009 and February 2010, a total of 5,051 persons from 20 to 49 years of age presenting for a health check-up were included and responded to a questionaire. The seroprevalence of HAV was investigated by measuring immunoglobulin G (IgG) anti-HAV. A total of 984 pairs of cases and age- and sex-matched controls were analyzed for associated socioeconomic factors. Results: The prevalence of seropositive HAV was 6.2% in the 20 to 29 age range, 33.1% in the 30 to 39 range and 82.4% in the 40 to 49 range (p<0.001). There were no signifi cant differences in any group according to gender. A multivariate analysis for paired cases indicated that HAV seropositivity was signifi cantly higher in the low monthly income (below five million won, approximately 4,300 dollars) group and the Helicobacterpylori (H. pylori)-positive group (odds ratio [OR], 1.65; 95% confi dence interval [CI], 1.27-2.14; p<0.001; OR, 1.45; 95% CI, 1.19-1.76; p<0.001, respectively). Conclusions: HAV seropositivity in young adults presenting for a health checkup appears to be decreasing, and the prevalence was signifi cantly higher in the low monthly income group and the H. pylori-positive group. (Gut Liver 2011;5:88-92)
Keywords: Hepatitis A virus; Seropositivity; Helicobacter pylori; Socioeconomic status
Abstract
Background/Aims: An epidemiologic shift of hepatitis A virus (HAV) seroprevalence is expected due to an improvement in socioeconomic status in young adults in Korea. We investigated the age-specific seroprevalence and socioeconomic factors associated with HAV seropositivity in young, healthy Korean adults. Methods: Between March 2009 and February 2010, a total of 5,051 persons from 20 to 49 years of age presenting for a health check-up were included and responded to a questionaire. The seroprevalence of HAV was investigated by measuring immunoglobulin G (IgG) anti-HAV. A total of 984 pairs of cases and age- and sex-matched controls were analyzed for associated socioeconomic factors. Results: The prevalence of seropositive HAV was 6.2% in the 20 to 29 age range, 33.1% in the 30 to 39 range and 82.4% in the 40 to 49 range (p<0.001). There were no signifi cant differences in any group according to gender. A multivariate analysis for paired cases indicated that HAV seropositivity was signifi cantly higher in the low monthly income (below five million won, approximately 4,300 dollars) group and the Helicobacterpylori (H. pylori)-positive group (odds ratio [OR], 1.65; 95% confi dence interval [CI], 1.27-2.14; p<0.001; OR, 1.45; 95% CI, 1.19-1.76; p<0.001, respectively). Conclusions: HAV seropositivity in young adults presenting for a health checkup appears to be decreasing, and the prevalence was signifi cantly higher in the low monthly income group and the H. pylori-positive group. (Gut Liver 2011;5:88-92)
Keywords: Hepatitis A virus; Seropositivity; Helicobacter pylori; Socioeconomic status
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