Gut and Liver 2011; 5(1): 100-104 https://doi.org/10.5009/gnl.2011.5.1.100 Cutaneous Metastasis from Cholangiocarcinoma as the First Clinical Sign: A Report of Two Cases
Author Information
Shin Young Hyun*, Ji Hoon Lee*, Hye Sun Shin*, Su Whan Lee*, Young Nyun Park†,‡§, and Jun Yong Park*,‡,§
Departments of *Internal Medicine, Pathology, Institute of Gastroenterology, and §Liver Cancer Special Clinic, Yonsei University College of Medicine, Seoul, Korea

Jun Yong Park
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

Abstract
Cutaneous metastases from internal malignancies are uncommon. Furthermore, cutaneous metastases from cholangiocarcinoma are extremely rare. Here we report a case of two patients with distant cutaneous metastases of cholangiocarcinoma: 1) a 66-year-old man who presented with a solitary, erythematous nodule on the scalp and 2) a 44-yearold man who presented with multiple, erythematous nodules on the scalp, the chest wall, and the back. In both cases, the erythematous nodules were the first clinical signs of cholangiocarcinoma. Histopathological analyses of skin biopsy specimens of the two patients revealed adenocarcinomas with features similar to the original cholangiocarcinoma. Two cases of cholangiocarcinoma in which metastatic skin nodules appeared as the fi rst sign of the disease are reported here, with a review of the relevant literature. (Gut Liver 2011;5:100-104)
Keywords: Cutaneous metastasis; Cholangiocarcinoma
Abstract
Cutaneous metastases from internal malignancies are uncommon. Furthermore, cutaneous metastases from cholangiocarcinoma are extremely rare. Here we report a case of two patients with distant cutaneous metastases of cholangiocarcinoma: 1) a 66-year-old man who presented with a solitary, erythematous nodule on the scalp and 2) a 44-yearold man who presented with multiple, erythematous nodules on the scalp, the chest wall, and the back. In both cases, the erythematous nodules were the first clinical signs of cholangiocarcinoma. Histopathological analyses of skin biopsy specimens of the two patients revealed adenocarcinomas with features similar to the original cholangiocarcinoma. Two cases of cholangiocarcinoma in which metastatic skin nodules appeared as the fi rst sign of the disease are reported here, with a review of the relevant literature. (Gut Liver 2011;5:100-104)
Keywords: Cutaneous metastasis; Cholangiocarcinoma
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