Gut and Liver 2010; 4(2): 266-269 https://doi.org/10.5009/gnl.2010.4.2.266 Pathological Complete Remission of Advanced Hepatocellular Carcinoma with Main Portal Vein Tumor Thrombosis by Hepatic Arterial Infusion Chemotherapy
Author Information
Yong Gil Kim*, Jong Ryul Eun*, Tae Nyeun Kim*, Heon Ju Lee*, Jae Woon Kim, Jay Chun Chang, Sung Su Yun, and Joon Hyuk Choi§
Departments of *Internal Medicine, Radiology, Surgery, and §Pathology, Yeungnam University College of Medicine, Daegu, Korea

Jong Ryul Eun
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

Abstract
Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT. (Gut Liver 2010;4:266-269)
Keywords: Hepatocellular carcinoma; Portal vein tumor thrombosis; Chemotherapy; 5-fluorouracil; Complete remission
Abstract
Cures for advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) are rare and difficult. We report a case of pathologically confirmed complete remission of HCC induced by hepatic arterial infusion chemotherapy (HAIC). A 45-year-old male patient had a massive HCC in the right lobe of the liver and tumor thrombus in the right and main portal veins. He achieved a partial response after two cycles of HAIC with 5-fluorouracil (750 mg/m2) and cisplatin (25 mg/m2). After the completion of six cycles he received a curative partial hepatectomy, and histopathology revealed complete necrosis without any viable tumor cell. He was in good health at a 4-month follow-up. These results suggest that this regimen is a promising therapeutic modality for the treatment of advanced HCC with PVTT. (Gut Liver 2010;4:266-269)
Keywords: Hepatocellular carcinoma; Portal vein tumor thrombosis; Chemotherapy; 5-fluorouracil; Complete remission
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