Gut and Liver 2010; 4(2): 186-191 https://doi.org/10.5009/gnl.2010.4.2.186 Efficacy and Safety of Endoscopic Submucosal Dissection for Early Gastric Cancer in Patients with Comorbid Diseases
Author Information
Beom Jin Kim*, Tae Hoon Chang, Jae J. Kim, Byung-Hoon Min, Jun Haeng Lee, Hee Jung Son, Poong-Lyul Rhee, Jong Chul Rhee, Kyung Mee Kim, and Chul Keun Park
*Department of Internal Medicine, Chung-Ang University College of Medicine, Departments of Medicine and Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Jae J. Kim
© The Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Association the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, Korean Pancreatobiliary Association, and Korean Society of Gastrointestinal Cancer. All rights reserved.

Abstract
Background/Aims: Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time and the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated the efficacy and safety of ESD in patients with comorbid diseases. Methods: The outcomes of 337 patients who underwent ESD for early gastric cancer at Samsung Medical Center from April 2003 to December 2006 were analyzed retrospectively. The Charlson comorbidity scale was used to divide the patients into low-risk (no risk factor) and high-risk (at least one risk factor) groups. The outcomes and complications were compared between the high-and low- risk groups. Results: The low- and high-risk groups comprised 240 and 97 patients with mean ages of 61.1 and 64.7 years, respectively (p=0.002). Tumor location, tumor size, depth of invasion, procedure duration, and rates of en bloc resection, complete resection, complication, and recurrence did not differ significantly between the two groups (p>0.05). Conclusions: ESD may be a safe and effective treatment for early gastric cancer in patients with comorbid diseases. (Gut Liver 2010;4:186- 191)
Keywords: Early gastric cancer; Endoscopic submucosal dissection; Comorbid disease; Complication
Abstract
Background/Aims: Endoscopic submucosal dissection (ESD), a new and potentially curative method for treating gastrointestinal neoplasms, may have longer procedure time and the risk of complications when compared to conventional endoscopic mucosal resection. This study evaluated the efficacy and safety of ESD in patients with comorbid diseases. Methods: The outcomes of 337 patients who underwent ESD for early gastric cancer at Samsung Medical Center from April 2003 to December 2006 were analyzed retrospectively. The Charlson comorbidity scale was used to divide the patients into low-risk (no risk factor) and high-risk (at least one risk factor) groups. The outcomes and complications were compared between the high-and low- risk groups. Results: The low- and high-risk groups comprised 240 and 97 patients with mean ages of 61.1 and 64.7 years, respectively (p=0.002). Tumor location, tumor size, depth of invasion, procedure duration, and rates of en bloc resection, complete resection, complication, and recurrence did not differ significantly between the two groups (p>0.05). Conclusions: ESD may be a safe and effective treatment for early gastric cancer in patients with comorbid diseases. (Gut Liver 2010;4:186- 191)
Keywords: Early gastric cancer; Endoscopic submucosal dissection; Comorbid disease; Complication
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