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Fig. 3. Effect of PMK-S005 on the levels of proinflammatory cytokines and COX-2 expression with aging. The mucosal levels of tumor necrosis factor α (TNF-α) (A) and interleukin 1β (IL-1β) (B) were determined using an enzyme-linked immunosorbent assay. COX-2 protein expression in the gastric mucosa was evaluated by Western blot analysis (C). A representative Western blot assay is shown (D). The results are expressed as the means±SEM of five animals per group.

PMK5, 5 mg/kg of PMK-S005; PMK10, 10 mg/kg of PMK-S005; Lanso, 5 mg/kg of Lansoprazole. *p<0.05 compared with the 6-week-old controls; p<0.05 compared with the 31-week-old controls; p<0.05 compared with the 74-week-old controls; §p<0.05 compared with the 2-year-old controls.

Gut and Liver 2016;10:749~756 https://doi.org/10.5009/gnl15584
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