pISSN 1976-2283
eISSN 2005-1212

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Fig. 1. A putative pathogenic model of cholangiopathies. The initial insult to biliary epithelial cells and the host response may induce an inflammatory reaction. It generally resolves with the resolution of the insulting agent to the biliary tree. However, the persistence of insults to the biliary tree and/or derangement of the host response will lead to chronic inflammation, cholestasis, and bile duct proliferation and ductopenia. Ultimately, chronic cholangiopathies progress to biliary fibrosis and/or malignant transformation.
Gut Liver 2012;6:295~304 https://doi.org/10.5009/gnl.2012.6.3.295
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