pISSN 1976-2283
eISSN 2005-1212

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Fig. 2. The signaling pathways linked to hepatic cancer stem cells (CSCs) in hepatocarcinogenesis. Key signaling pathways that regulate the function of hepatic CSCs include Wnt/β-catenin, transforming growth factor (TGF-β), Hedgehog, Notch, and MYC. Epithelial cell adhesion molecule (EpCAM) is a Wnt/β-catenin signaling target gene, and activation of Wnt/β-catenin signaling regulates EpCAM expression in hepatocellular carcinoma (HCC) cell lines. In CD133+ HCC cells, Wnt/β-catenin, Notch1, and smoothened (SMO)/Hedgehog signaling pathways are linked with self-renewal, differentiation, and proliferation of hepatic CSCs. Targeting of these critical pathways in the regulation of hepatic CSCs may be a promising tool for the development of new therapies to eradicate tumor cells completely in HCC.

Gli3, glioma-associated oncogene family zinc finger 3; TACE, TNF-alpha converting enzyme; PTC, patched.

Gut Liver 2012;6:29~40 https://doi.org/10.5009/gnl.2012.6.1.29
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