pISSN 1976-2283
eISSN 2005-1212

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Fig. 1. Two general models for tumorigenesis. The stochastic model claims that every cancer cell in a tumor can ultimately acquire a capacity for self-renewal and multilineage potency, thereby forming new tumors (A), whereas the hierarchy model claims that cancer cells in a tumor are heterogeneous and that only a minority of these cells serves as cancer stem cells (CSCs), thus giving rise to tumors (B).
Gut Liver 2012;6:29~40 https://doi.org/10.5009/gnl.2012.6.1.29
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