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Gut and Liver

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Articles

Clostridium difficile Infection: A Worldwide Disease

Kristin E. Burke and J. Thomas Lamont
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
ABSTRACT
Clostridium difficile, an anaerobic toxigenic bacterium, causes a severe infectious colitis that leads to significant morbidity and mortality worldwide. Both enhanced bacterial toxins and diminished host immune response contribute to symptomatic disease. C. difficile has been a well-established pathogen in North America and Europe for decades, but is just emerging in Asia. This article reviews the epidemiology, microbiology, pathophysiology, and clinical management of C. difficile. Prompt recognition of C. difficile is necessary to implement appropriate infection control practices. (Gut Liver 2014;8:1-6)
 
KEYWORD
Clostridium difficile; Epidemiology; Review; Asia
 
Gut and Liver 2014 Jan; 8(1): 1-6
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