Gut and Liver

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Chemoprevention of Gastrointestinal Cancer: The Reality and the Dream

Kyung-Soo Chun*, Eun-Hee KimΆΣ, Sooyeon LeeΆΣ, and Ki Baik HahmΆΤ
*Keimyung University College of Pharmacy, Daegu, ΆΣCHA University College of Pharmacy, Seoul, and ΆΤDepartment of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Despite substantial progress in screening, early diagnosis, and the development of noninvasive technology, gastrointestinal (GI) cancer remains a major cause of cancer-associated mortality. Chemoprevention is thought to be a realistic approach for reducing the global burden of GI cancer, and efforts have been made to search for chemopreventive agents that suppress acid reflux, GI inflammation and the eradication of Helicobacter pylori. Thus, proton pump inhibitors, statins, monoclonal antibodies targeting tumor necrosis factor-alpha, and nonsteroidal anti-inflammatory agents have been investigated for their potential to prevent GI cancer. Besides the development of these synthetic agents, a wide variety of the natural products present in a plant-based diet, which are commonly called phytoceuticals, have also sparked hope for the chemoprevention of GI cancer. To perform successful searches of chemopreventive agents for GI cancer, it is of the utmost importance to understand the factors contributing to GI carcinogenesis. Emerging evidence has highlighted the role of chronic inflammation in inducing genomic instability and telomere shortening and affecting polyamine metabolism and DNA repair, which may help in the search for new chemopreventive agents for GI cancer. (Gut Liver 2013;7:137-149)
Chemoprevention; Gastrointestinal neoplasms; Phytoceuticals; Molecular target
Gut and Liver 2013 Mar; 7(2): 137-149
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