Long-Term Outcome of Cystic Lesions in the Pancreas: A Retrospective Cohort Study
|Dong-Won Ahn*,¢Ó, Sang Hyub Lee*,¢Ô, Jaihwan Kim*, Won Jae Yoon*, Jin-Hyeok Hwang*,¢Ô, Jin-Young Jang¡×, Ji Kon Ryu*, Yong-Tae Kim*, Sun-Whe Kim¡×, and Yong Bum Yoon*|
|*Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, ¢ÓDepartment of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, ¢ÔDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, and ¡×Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea|
|This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Background/Aims: The management guidelines for cystic lesions of the pancreas (CLPs) are not yet well established. This study was performed to document the long-term clinical outcome of CLPs and provide guidelines for the management and surveillance of CLPs. |
Methods: In this retrospective cohort study, an additional follow-up was performed in 112 patients with CLPs enrolled from 1998 to 2004 during a previous study.
Results: During follow-up for the median period of 72.3 months, the size of the CLPs increased in 18 patients (16.1%). Six of these patients experienced growth of their CLPs after 5 years of follow-up. Twenty-six patients underwent surgery during follow-up, and four malignant cysts were detected. The overall rate of malignant progression during follow-up was 3.6%. The presence of mural nodules or solid components was independently associated with the presence of malignant CLPs. Seven patients underwent surgery after 5 years of follow-up. The pathologic findings revealed malignancies in two patients. There was only one pancreas-related death during follow-up.
Conclusions: The majority of CLPs exhibit indolent behavior and are associated with a favorable prognosis. However, long-term surveillance for more than 5 years should be performed because of the potential for growth and malignant transformation in CLPs. (Gut Liver 2012;6:493-500)
|Pancreatic cyst; Natural history; Prognosis|
|Gut and Liver 2012 Oct; 6(4): 493-500|